¹The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region of China

Abstract

Background: Although it has been proposed that polymorphic renal CYP3A5 expression may affect blood pressure by altering sodium and water retention, current data on the association between CYP3A5 genotype and blood pressure are controversial. While a previous study in 25 young healthy African Americans showed an increased blood pressure in subjects with CYP3A5*1 allele, another study in 136 White normotensives failed to find such a relationship. We carried out this study to investigate the relationship between CYP3A5 genotype and blood pressure in Chinese subjects.

Methods: A total of 93 healthy young Chinese subjects underwent 3 repeated sessions, during which blood pressure, heart rate and serum creatinine clearance were measured. CYP3A5 genotyping was performed using polymerase chain reaction and Ddel restriction analysis.

Results: The genotype frequency was 7.5%, 37.5% and 55.0% for CYP3A5*1/*1, *1/*3 and *3/*3 respectively. No significant differences were observed in the mean resting systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR) or creatinine clearance (CLcr) among these genotype groups as shown below: (Table).

Conclusions: Our study showed a lack of significant association between CYP3A5 genotype and blood pressure. This suggests that CYP3A5 polymorphism may not be a major determinant of blood pressure regulation in healthy Chinese subjects.