American Society for Clinical Pharmacology and Therapeutics
Clinical Pharmacology & Therapeutics (2005) 79, P8–P8; doi: 10.1016/j.clpt.2005.12.027
PI-6
Observation of the cruor time window of hydroxysafflor yellow a of the mice in vivo
L. Zhifeng1, L. Chunmei1, L. Guisheng1, L. Min1 and L. Ke*1
1School of Pharmacy, Yantai University, Yantai, Shandong Province, China
Abstract
Aim: To observe the cruor time window of Hydroxysafflor yellow A of the mice in vivo.
Methods: 70 male mice were divided into 7 groups, with the dose of 5 mg/kg, the drug was administrated ip to the mice once a day, continuously for 3-days. After the last administration for 1h, 2h, 4h, 8h, 16h, 24h, the cruor time were observed.
Results: The measured cruor time was markedly longer after the last administration in the 1h, 2h, 4h, 8h and 16h groups than control group (respectively 136.8
29.5 sec in 1h group and 97.624.3 sec in 16h group vs 65.222.9 sec of control), and the 24h group had no significant change.
Conclusions: The results showed that the treatment time window of Hydroxysafflor yellow A on cruor time of the mice in vivo may be continued to 16 hours after administration.
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