PI-4

doi:doi:10.1016/j.clpt.2005.12.025

Clinical Pharmacology & Therapeutics homepage

Clinical Pharmacology & Therapeutics (2005) 79, P8–P8; doi: 10.1016/j.clpt.2005.12.025

PI-4

The effects of itopride on plasma gut-regulatory peprides and stress-related hormones levels in healthy humans

F. Katagiri¹, S. Inoue¹, Y. Sato¹, H. Itoh PhD¹ and M. Takeyama PhD¹

¹Oita University Hospital, Oita, Japan

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Abstract

Background: Itopride, a gastrokinetic drug with anti-dopamine and anti-acetylcholinesterase activity, has recently been evaluated for its clinical usefulness in non-ulcer dyspepsia that is closely related to stress. Here, we studied the effects of itopride on human plasma gastrin-, somatostatin-, motilin- and CCK-like immunoreactive substance (IS), and ACTH-IS and cortisol under stress conditions using repetitive blood sampling in healthy subjects.

Methods: Itopride at a dose of 150 mg or placebo was orally administered in five healthy male volunteers. The blood samples were taken before and till 240 min after administration, followed by the extracting procedure, and submitted to the high sensitive enzyme immunoassay system as previously developed.

Results: Single administration of itopride caused significant (P < 0.05) increases in plasma somatostatin- and motilin-IS levels, and decreases in plasma CCK-IS levels, compared with placebo. Furthermore, itopride suppressed plasma ACTH-IS levels significantly.

Conclusion: In this study, we hypothesize that itopride which is used as a prokinetic drug via motilin, somatostatin and CCK, could also be used to treat stress-related diseases.