FIGURES AND TABLES

Figure 1.

Mean (SE) (n = 4) rates of flurbiprofen hydroxylation by human liver microsomes in vitro, with reaction velocities expressed as a percent of uninhibited control value. IC₅₀ values (inhibitor concentration reducing reaction velocity to 50% of control value) for cranberry juice and brewed tea were determined by nonlinear regression analysis of aggregate data points as described in the text.

Figure 2.

The same in vitro system as in Fig 1, except that fluconazole is the inhibitor. The IC₅₀ value is based on the aggregate data and is nearly identical to the mean IC₅₀ value of 29.9 mol/L from a separate analysis of the 4 individual liver samples. Note that 1 mol/L equals 0.306 g/mL.

Figure 3.

Mean (SE) (n = 14) plasma flurbiprofen concentrations at corresponding times during 3 of the cotreatment trials: with cranberry juice placebo, with cranberry juice, and with fluconazole.

Figure 4.

Mean (SE) (n = 14) plasma fluconazole concentrations in the fluconazole cotreatment condition (trial 5). Note that 1 g/mL equals 3.26 mol/L.

Table I - Effect of beverages and sulfaphenazole on flurbiprofen hydroxylation by human liver microsomes in vitro.