TABLE OF CONTENTS

Volume 77, Issue 5 (May 2005)

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Perspectives in Clinical Pharmacology

Cytochrome P450 2C8: Substrates, Inhibitors, Pharmacogenetics, and Clinical Relevance

Rheem A. Totah PhD and Allan E. Rettie PhD

Clin Pharmacol Ther 77: 341-352; doi:10.1016/j.clpt.2004.12.267

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Pharmacogenetics and Genomics

CYP2C9 Haplotype Structure in European American Warfarin Patients and Association with Clinical Outcomes

David L. Veenstra, David K. Blough, Mitchell K. Higashi, Frederico M. Farin, Sengkeo Srinouanprachan, Mark J. Rieder and Allan E. Rettie

Clin Pharmacol Ther 77: 353-364; doi:10.1016/j.clpt.2005.01.019

Common Genetic Variants of Microsomal Epoxide Hydrolase Affect Warfarin Dose Requirements Beyond the Effect of Cytochrome P450 2C9

Ronen Loebstein MD, Manuela Vecsler BSc, Daniel Kurnik MD, Naomi Austerweil BSc, Eva Gak PhD, Hillel Halkin MD and Shlomo Almog PhD

Clin Pharmacol Ther 77: 365-372; doi:10.1016/j.clpt.2005.01.010

Genotype-phenotype Associations of Cytochrome P450 3A4 and 3A5 Polymorphism with Midazolam Clearance in Vivo

Ping He MD, Michael H. Court BVSc, PhD, David J. Greenblatt MD and Lisa L. von Moltke MD

Clin Pharmacol Ther 77: 373-387; doi:10.1016/j.clpt.2004.11.112

Human Response to alpha2-adrenergic Agonist Stimulation Studied in an Isolated Vascular Bed in Vivo: Biphasic Influence of Dose, Age, Gender, and Receptor Genotype

Danuta King MD, Jason P. Etzel BS, Shagun Chopra MD, Joshua Smith BS, Peter E. Cadman MD, Fangwen Rao MD, Stephen D. Funk PharmD, Brinda K. Rana PhD, Nicholas J. Schork PhD, Paul A. Insel MD and Daniel T. O'Connor MD

Clin Pharmacol Ther 77: 388-403; doi:10.1016/j.clpt.2005.02.008

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Pharmacokinetics and Drug Disposition

Effects of Gemfibrozil, Itraconazole, and Their Combination on the Pharmacokinetics of Pioglitazone

Tiina Jaakkola MD, Janne T. Backman MD, Mikko Neuvonen MSc and Pertti J. Neuvonen MD

Clin Pharmacol Ther 77: 404-414; doi:10.1016/j.clpt.2004.12.266

In Vivo Effects of Goldenseal, Kava Kava, Black Cohosh, and Valerian on Human Cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 Phenotypes

Bill J. Gurley PhD, Stephanie F. Gardner PharmD, EdD, Martha A. Hubbard MS, D. Keith Williams PhD, W. Brooks Gentry MD, Ikhlas A. Khan PhD and Amit Shah

Clin Pharmacol Ther 77: 415-426; doi:10.1016/j.clpt.2005.01.009

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Clinical Trials

A Pharmacokinetic-pharmacodynamic Model for the Mobilization of CD34+ Hematopoietic Progenitor Cells by AMD3100

N. A. Lack BSc, B. Green MSc, DPh, D. C. Dale MD, G. B. Calandra MD, PhD, H. Lee MD, PhD, R. T. MacFarland PhD, K. Badel BScN, W. C. Liles MD, PhD and G. Bridger PhD

Clin Pharmacol Ther 77: 427-436; doi:10.1016/j.clpt.2004.12.268

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Pharmacodynamics and Drug Action

Renal Effects of the Cyclooxygenase-inhibiting Nitric Oxide Donator AZD3582 Compared with Rofecoxib and Naproxen During Normal and Low Sodium Intake

Gunilla Huledal MSc(Pharm), Bror Jonzon MD, PhD, Maria Malmenäs MSc, Ann Hedman MSc(Pharm), PhD, Lars I. Andersson PhD, Bo Odlind MD, PhD and D. Craig Brater MD

Clin Pharmacol Ther 77: 437-450; doi:10.1016/j.clpt.2005.01.011

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Letters to the Editor

Herbal Medicines in Malaysia

Hooi-Hoon Ang BPharm(Hons), PhD

Clin Pharmacol Ther 77: 451; doi:10.1016/j.clpt.2005.01.016

Linezolid and Rifampin: Drug Interaction Contrary to Expectations?

Hannes Egle PhD, Rainer Trittler PhD, Klaus Kümmerer and Sebastian W. Lemmen MD

Clin Pharmacol Ther 77: 451-453; doi:10.1016/j.clpt.2005.01.020

Traditional Aqueous Kava Extracts Inhibit Cytochrome P450 1A2 in Humans: Protective Effect Against Environmental Carcinogens?

Stefan Russmann MD, Bernhard H. Lauterburg MD, Yann Barguil PharmD, Erwan Choblet MD, Pierre Cabalion PhD, Katharina Rentsch PhD and Markus Wenk PhD

Clin Pharmacol Ther 77: 453-454; doi:10.1016/j.clpt.2005.01.021

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Book Received

Books Received

Clin Pharmacol Ther 77: 455-456; doi:10.1016/j.clpt.2005.02.007

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Corrections

Correction FREE

Clin Pharmacol Ther 77: 456; doi:10.1016/j.clpt.2005.03.001

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