TABLE IV
FROM:
The bioavailability of intranasal and smoked methamphetamine
Debra S. Harris, Harold Boxenbaum, E. Thomas Everhart, Gina Sequeira, John E. Mendelson and Reese T. Jones
BACK TO ARTICLETable IV. Amphetamine-d0 plasma pharmacokinetic parameters after methamphetamine administered intranasally or smoked (simultaneously with 10 mg intravenous deuterated methamphetamine by constant-rate intravenous infusion over 15 minutes)
| Route | Cmax (ng/mL) | tmax (h) | AUC(0-tlast) (ng  h/mL) | AUC(0- ) (ng h/mL) | AUCext (%) |  z (L/h) | t1/2 (h) | Plasma AUC(0-) ratio: Amphetamine/methamphetamine (%) |
|---|---|---|---|---|---|---|---|---|
| Intranasal 50 mg | 9.12  2.39 | 17.3 5.95 | 344 102 | 371 104 | 7.63 6.65 | 0.0509 0.0150 | 15.2 6.42 | 19.3 6.01 |
| Smoked 40 mg | 3.71 2.88 | 15.3 5.12 | 129 115 | 148 122 | 14.3 8.78 | 0.0460 0.0148 | 16.3 4.45 | 17.8 6.23 |
Data are presented as mean SD.
