TABLE III
FROM:
The bioavailability of intranasal and smoked methamphetamine
Debra S. Harris, Harold Boxenbaum, E. Thomas Everhart, Gina Sequeira, John E. Mendelson and Reese T. Jones
BACK TO ARTICLETable III. Amphetamine-d3 plasma pharmacokinetic parameters after 10 mg deuterated methamphetamine administered intravenously by constant-rate intravenous infusion (15 minutes)
| Concomitant dosing | Cmax (ng/mL) | tmax (h) | AUC(0-tlast) (ng  h/mL) | AUC(0- ) (ng h/mL) | AUCext (%) |  z (L/h) | t1/2 (h) | Plasma AUC(0-) ratio: Amphetamine/methamphetamine (%) |
|---|---|---|---|---|---|---|---|---|
| Intranasal 50 mg | 1.85  0.50 | 18.8 5.95 | 63.1 22.2 | 73.8 17.8 | 16.3 15.2 | 0.0479 0.0153 | 16.2 6.35 | 15.5 5.79 |
| Smoked 40 mg | 2.00 0.874 | 16.8 5.75 | 66.8 35.2 | 80.0 34.0 | 18.8 15.3 | 0.0437 0.0125 | 16.9 4.37 | 16.1 5.55 |
Data are presented as mean SD.
