TABLE OF CONTENTS

Volume 73, Issue 1 (January 2003)

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Commentaries

Clinical Pharmacology & Therapeutics—An update FREE

C. Michael Stein MD

Clin Pharmacol Ther 73: 1-3; doi:10.1067/mcp.2003.31

Drug labeling should be kept current FREE

Anil Rajpal MD and Marcus M. Reidenberg MD

Clin Pharmacol Ther 73: 4-6; doi:10.1067/mcp.2003.20

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Pharmacokinetics and Drug Disposition

A rational approach for selection of optimal covariate-based dosing strategies  FREE

Siv Jönsson MSc and Mats O. Karlsson PhD

Clin Pharmacol Ther 73: 7-19; doi:10.1067/mcp.2003.2

Population pharmacokinetics and effects of efavirenz in patients with human immunodeficiency virus infection  FREE

Chantal Csajka PharmD, PhD, Catia Marzolini PharmD, PhD, Karin Fattinger MD, Laurent A. Décosterd PhD, Jacques Fellay MD, Amalio Telenti MD, PhD, Jérôme Biollaz MD and Thierry Buclin MD

Clin Pharmacol Ther 73: 20-30; doi:10.1067/mcp.2003.22

Population analyses of sustained-release verapamil in patients: Effects of sex, race, and smoking  FREE

Dongwoo Kang PhD, Davide Verotta PhD, Mary Ellen Krecic-Shepard PhD, Nishit B. Modi PhD, Suneel K. Gupta PhD and Janice B. Schwartz MD

Clin Pharmacol Ther 73: 31-40; doi:10.1067/mcp.2003.21

Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects  FREE

George K. Dresser MD, Ute I. Schwarz MD, Grant R. Wilkinson PhD, DSc and Richard B. Kim MD

Clin Pharmacol Ther 73: 41-50; doi:10.1067/mcp.2003.10

Dipyridamole enhances digoxin bioavailability via P-glycoprotein inhibition  FREE

Céline Verstuyft PharmD, Soraya Strabach MD, Hakima El Morabet BSc, Reinhold Kerb MD, Ulrich Brinkmann PhD, Liliane Dubert BSc, Patrice Jaillon MD, Christian Funck-Brentano MD, PhD, Germain Trugnan MD, PhD and Laurent Becquemont MD, PhD

Clin Pharmacol Ther 73: 51-60; doi:10.1067/mcp.2003.8

Effects of age and sex on the disposition of retigabine  FREE

Robert Hermann MD, Geraldine M. Ferron PharmD, PhD, Katharina Erb MD, Norbert Knebel PhD, Peter Ruus MD, Jeffrey Paul PhD, Lyette Richards MA, Hans-Peter Cnota MD and Steven Troy MSc

Clin Pharmacol Ther 73: 61-70; doi:10.1067/mcp.2003.12

Transfer of metformin into human milk  FREE

Sharon J. Gardiner MClinPharm, Carl M.J. Kirkpatrick PhD, Evan J. Begg MD, Mei Zhang MMed, M.Peter Moore FRACP and Dorothy J. Saville PhD

Clin Pharmacol Ther 73: 71-77; doi:10.1067/mcp.2003.9

Effects of nelfinavir and its M8 metabolite on lymphocyte P-glycoprotein activity during antiretroviral therapy  FREE

John P. Donahue PhD, David Dowdy MS, Krishna K. Ratnam MS, Todd Hulgan MD, James Price PhD, Derya Unutmaz PhD, Janet Nicotera BSN, Steven Raffanti MD, Mark Becker PharmD and David W. Haas MD

Clin Pharmacol Ther 73: 78-86; doi:10.1067/mcp.2003.11

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Pharmacodynamics and Drug Action

Teriparatide has no effect on the calcium-mediated pharmacodynamics of digoxin  FREE

Charles T. Benson MD, PhD and James R. Voelker MD

Clin Pharmacol Ther 73: 87-94; doi:10.1067/mcp.2003.7

Population pharmacodynamic analysis of octreotide in acromegalic patients  FREE

Emmanuelle Comets PhD, France Mentré PhD, MD, Peter Grass PhD, Ryosei Kawai PhD, Peter Marbach PhD and Jacky Vonderscher PhD

Clin Pharmacol Ther 73: 95-106; doi:10.1067/mcp.2003.6

Analgesic effects of morphine and morphine-6-glucuronide in a transcutaneous electrical pain model in healthy volunteers  FREE

Carsten Skarke MD, Jutta Darimont, Helmut Schmidt MSc, Gerd Geisslinger MD, PhD and Jörn Lötsch MD

Clin Pharmacol Ther 73: 107-121; doi:10.1067/mcp.2003.5

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Pharmacogenetics and Genomics

Genetic variation in cyclooxygenase 1: Effects on response to aspirin  FREE

Marc K. Halushka MD, PhD, Linda P. Walker BS and Perry V. Halushka MD, PhD

Clin Pharmacol Ther 73: 122-130; doi:10.1067/mcp.2003.1

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