TABLE OF CONTENTS
Volume 70, Issue 2 (August 2001)
Pharmacokinetics and Drug Disposition |
Pharmacoepidemiology and Drug Utilization |
Pharmacogenetics and Genomics
Commentaries
Optimizing drug development: Strategies to assess drug metabolism/transporter interaction potential-toward a consensus
Geoffrey T. Tucker PhD, J. Brian Houston PhD and Shiew-Mei Huang PhD
Clin Pharmacol Ther 70: 103-114; doi:10.1067/mcp.2001.116891
Demonstrating effectiveness in a post-placebo era
John Urquhart MD, FRCP(Edin)
Clin Pharmacol Ther 70: 115-120; doi:10.1067/mcp.2001.117285
Pharmacokinetics and Drug Disposition
The effect of pregnancy on cytochrome P4501A2, xanthine oxidase, and N-acetyltransferase activities in humans
Kimiko Tsutsumi PhD, Tsutomu Kotegawa MD, PhD, Shunji Matsuki MD, PhD, Yuichiro Tanaka MD, PhD, Yoko Ishii MD, PhD, Yasuo Kodama BS, Masae Kuranari BS, Isao Miyakawa MD, PhD and Shigeyuki Nakano MD, PhD
Clin Pharmacol Ther 70: 121-125; doi:10.1067/mcp.2001.116495
Effect of ranitidine on the pharmacokinetics of triazolam and 
-hydroxytriazolam in both young (19-60 years) and older (61-78 years) people
Robin L. O'Connor-Semmes PhD, Kathryn Kersey MSc, Daphne H. Williams PhD, Raymond Lam MSc and Kevin M. Koch PhD
Clin Pharmacol Ther 70: 126-131; doi:10.1067/mcp.2001.117120
Modulation of the cytochrome P450–mediated metabolism of ifosfamide by ketoconazole and rifampin
Thomas Kerbusch PhD, Rob L. H. Jansen MD, PhD, Ron A. A. Mathôt PhD, Alwin D. R. Huitema PhD, Myra Jansen RN, Ruud E. N. van Rijswijk MD and Jos H. Beijnen PhD
Clin Pharmacol Ther 70: 132-141; doi:10.1067/mcp.2001.117283
Erythromycin increases plasma concentrations of -dihydroergocryptine in humans
Christian de Mey MD, Michael Althaus MD, Eric Ezan PhD and Angelika Retzow PhD
Clin Pharmacol Ther 70: 142-148; doi:10.1067/mcp.2001.117286
A pharmacokinetic study of intermittent rifabutin dosing with a combination of ritonavir and saquinavir in patients infected with human immunodeficiency virus
Keith Gallicano PhD, Yasmin Khaliq PharmD, Germain Carignan BSc, Alice Tseng PharmD, Sharon Walmsley MD and D. William Cameron MD
Clin Pharmacol Ther 70: 149-158; doi:10.1067/mcp.2001.117612
Pharmacoepidemiology and Drug Utilization
Interindividual variability in sensitivity to warfarin-Nature or nurture?
Ronen Loebstein MD, Hagith Yonath MD, Daria Peleg MSc, Shlomo Almog PhD, Michal Rotenberg PhD, Aharon Lubetsky MD, Joseph Roitelman PhD, Dror Harats MD, Hillel Halkin MD and David Ezra MD
Clin Pharmacol Ther 70: 159-164; doi:10.1067/mcp.2001.117444
Pharmacogenetics and Genomics
Influence of the variable number of tandem repeats located in the promoter region of the thiopurine methyltransferase gene on enzymatic activity
Sandra Alves MSc, António Amorim PhD, Fátima Ferreira MD and Maria João Prata PhD
Clin Pharmacol Ther 70: 165-174; doi:10.1067/mcp.2001.117284
Genetic polymorphisms and functional characterization of the 5'-flanking region of the human CYP2C9 gene: In vitro and in vivo studies
Masayuki Shintani BS, Ichiro Ieiri PhD, Kazuko Inoue BS, Kohsuke Mamiya MD, Hideaki Ninomiya MD, Nobutada Tashiro MD, Shun Higuchi PhD and Kenji Otsubo PhD
Clin Pharmacol Ther 70: 175-182; doi:10.1067/mcp.2001.117367
Detection of one single mutation predicts thiopurine S-methyltransferase activity in a population of Saami in northern Norway
Thrina Loennechen PhD, Egil Utsi MD, Ingeborg Hartz MSci, Roy Lysaa MSci, Hanne Kildalsen MSci and Jarle Aarbakke MD
Clin Pharmacol Ther 70: 183-188; doi:10.1067/mcp.2001.117445
Identification of functionally variant MDR1 alleles among European Americans and African Americans
Richard B. Kim MD, Brenda F. Leake BSc, Edna F. Choo PhD, George K. Dresser MD, Samir V. Kubba MD, Ute I. Schwarz MD, Amanda Taylor, Hong-Guang Xie MD, Joel McKinsey MD, Sheng Zhou PhD, Lu-Bin Lan PhD, John D. Schuetz PhD, Erin G. Schuetz PhD and Grant R. Wilkinson PhD
Clin Pharmacol Ther 70: 189-199; doi:10.1067/mcp.2001.117412
