TABLE OF CONTENTS
Volume 69, Issue 3 (March 2001)
Pharmacokinetics and Drug Disposition |
Pharmacodynamics and Drug Action |
Clinical Trials |
Pharmacogenetics and Genomics |
Pharmacoepidemiology and Drug Utilization
Commentary
Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework
Biomarkers Definitions Working Group
Arthur J. Atkinson Jr MD, Wayne A. Colburn PhD, MDS, Victor G. DeGruttola ScD, David L. DeMets PhD, Gregory J. Downing DO, PhD, Daniel F. Hoth MD, John A. Oates MD, Carl C. Peck MD, Robert T. Schooley MD, Bert A. Spilker PhD, MD, Janet Woodcock MD and Scott L. Zeger PhD
Clin Pharmacol Ther 69: 89-95; doi:10.1067/mcp.2001.113989
Pharmacokinetics and Drug Disposition
Loratadine and terfenadine interaction with nefazodone: Both antihistamines are associated with QTc prolongation
Darrell R. Abernethy MD, PhD, Jean T. Barbey MD, John Franc PhD, Karen S. Brown MA, Irene Feirrera, Neville Ford MD, PhD and Daniel E. Salazar PhD
Clin Pharmacol Ther 69: 96-103; doi:10.1067/mcp.2001.114230
Effect of fluvoxamine on the pharmacokinetics of mexiletine in healthy Japanese men
Masaaki Kusumoto BS, Kazuyuki Ueno PhD, Ayumi Oda BS, Kazuya Takeda BS, Kohji Mashimo BS, Kameda Takaya BS, Yasuo Fujimura BS, Takako Nishihori BS and Kazuhiko Tanaka MD
Clin Pharmacol Ther 69: 104-107; doi:10.1067/mcp.2001.113182
Stereoselective pharmacokinetics of pantoprazole, a proton pump inhibitor, in extensive and poor metabolizers of S-mephenytoin
Makoto Tanaka PhD, Tadashi Ohkubo PhD, Koichi Otani MD, PhD, Akihito Suzuki MD, Sunao Kaneko MD, PhD, Kazunobu Sugawara PhD, Yuichi Ryokawa BS and Takashi Ishizaki MD, PhD
Clin Pharmacol Ther 69: 108-113; doi:10.1067/mcp.2001.113723
The effect of rifampin administration on the disposition of fexofenadine
Mitchell A. Hamman BS, Melissa A. Bruce MD, Barbara D. Haehner-Daniels MD and Stephen D. Hall PhD
Clin Pharmacol Ther 69: 114-121; doi:10.1067/mcp.2001.113697
Pharmacodynamics and Drug Action
Comparison of sympathetic modulation induced by single oral doses of mibefradil, amlodipine, and nifedipine in healthy volunteers
Isabelle Ragueneau MD, Anne Buu Sao MD, Jean-Louis Démolis MD, Bernadette Darné MD, Christian Funck-Brentano MD, PhD and Patrice Jaillon MD
Clin Pharmacol Ther 69: 122-129; doi:10.1067/mcp.2001.113406
Effect of angiotensin II on venodilator response to nitroglycerin
Kazuhiro Harada MD, Ko-ichi Sugimoto MD, Atsuhiro Kawaguchi PharmD, Masami Ohmori MD and Akio Fujimura MD
Clin Pharmacol Ther 69: 130-136; doi:10.1067/mcp.2001.113374
Clinical Trials
Effect of mycophenolate mofetil therapy on inosine monophosphate dehydrogenase induction in red blood cells of heart transplant recipients
Guenter Weigel MD, Andrea Griesmacher MD, Andreas O. Zuckermann MD, Guenther Laufer MD and Mathias M. Mueller MD
Clin Pharmacol Ther 69: 137-144; doi:10.1067/mcp.2001.114166
Pharmacokinetics and pharmacodynamics of sotalol in a pediatric population with supraventricular and ventricular tachyarrhythmia
J. Philip Saul MD, Bertrand Ross MD, Michael S. Schaffer MD, Lee Beerman MD, Armen P. Melikian PhD, PharmD, Jun Shi MD, John Williams MD, Jean T. Barbey MD, Judy Jin PhD, Peter H. Hinderling MD, PhD, the Pediatric Sotalol InvestigatorsDianne Atkins, David Chan, MacDonald Dick, Michael R. Epstein, Christopher Erickson, Frank A. Fish, Steven Fishberger, Richard Friedman, J. Edward Hulse, Ronald J. Kanter, Peter Karpawich, Robert Pass, William Scott, Margret Strieper, Ronn Tanel, John Triedman, George F. Van Hare and Frank Zimmerman
Clin Pharmacol Ther 69: 145-157; doi:10.1067/mcp.2001.113795
Pharmacogenetics and Genomics
Effect of genotypic differences in CYP2C19 on cure rates for Helicobacter pylori infection by triple therapy with a proton pump inhibitor, amoxicillin, and clarithromycin
Takahisa Furuta MD, Naohito Shirai MD, Misako Takashima MD, Fang Xiao MD, Hiroyuki Hanai MD, Haruhiko Sugimura MD, Kyoichi Ohashi MD, Takashi Ishizaki MD and Eizo Kaneko MD
Clin Pharmacol Ther 69: 158-168; doi:10.1067/mcp.2001.113959
Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects
Ingolf Cascorbi MD, PhD, Thomas Gerloff MD, Andreas Johne MD, Christian Meisel MD, Sven Hoffmeyer PhD, Matthias Schwab MD, Elke Schaeffeler PhD, Michel Eichelbaum MD, Ulrich Brinkmann PhD and Ivar Roots MD
Clin Pharmacol Ther 69: 169-174; doi:10.1067/mcp.2001.114164
