TABLE OF CONTENTS
Volume 68, Issue 2 (August 2000)
Pharmacokinetics and Drug Disposition |
Pharmacodynamics and Drug Action |
Pharmacogenetics and Genomics
Commentaries
Centers for Education and Research in Therapeutics
Marcus M. Reidenberg MD
Clin Pharmacol Ther 68: 109-110; doi:10.1067/mcp.2000.108505
A century of discovery: The pharmacologic revolution
Jean Gray MD, FRCPC
Clin Pharmacol Ther 68: 111-113; doi:10.1067/mcp.2000.108948
Pharmacokinetics and Drug Disposition
Pronounced effect of caprylocaproyl macrogolglycerides on nasal absorption of IS-159, a peptide serotonin 1B/1D-receptor agonist
Jasper Dingemanse PhD, PharmD, Catherine Soubrouillard MD, Jérôme Paris MD, Pascale Pisano PhD and Olivier Blin MD, PhD
Clin Pharmacol Ther 68: 114-121; doi:10.1067/mcp.2000.108196
Plasma concentrations of active simvastatin acid are increased by gemfibrozil
Janne T. Backman MD, Carl Kyrklund MB, Kari T. Kivistö MD, Jun-Sheng Wang MD and Pertti J. Neuvonen MD
Clin Pharmacol Ther 68: 122-129; doi:10.1067/mcp.2000.108507
Race and sex influence clearance of nifedipine: Results of a population study
Mary Ellen Krecic-Shepard PhD, Kyungsoo Park PhD, Crissy Barnas MS, Jill Slimko RN, Diana R. Kerwin MD and Janice B. Schwartz MD
Clin Pharmacol Ther 68: 130-142; doi:10.1067/mcp.2000.108678
Pharmacokinetics of landiolol hydrochloride, a new ultra-short-acting 
-blocker, in patients with cardiac arrhythmias
Hirotsugu Atarashi MD, Akinori Kuruma MD, Masa-aki Yashima MD, Hirokazu Saitoh MD, Takeshi Ino MD, Yasumi Endoh MD and Hirokazu Hayakawa MD
Clin Pharmacol Ther 68: 143-150; doi:10.1067/mcp.2000.108733
No sex-related differences but significant inhibition by oral contraceptives of CYP2C19 activity as measured by the probe drugs mephenytoin and omeprazole in healthy Swedish white subjects
Kari Laine MD, PhD, Gunnel Tybring PhD and Leif Bertilsson PhD
Clin Pharmacol Ther 68: 151-159; doi:10.1067/mcp.2000.108949
Morphine clearance and effects in newborn infants in relation to gestational age
Elina Saarenmaa MD, Pertti J. Neuvonen MD, Per Rosenberg MD and Vineta Fellman MD
Clin Pharmacol Ther 68: 160-166; doi:10.1067/mcp.2000.108947
Pharmacodynamics and Drug Action
Transdermal nicotine mimics the smoking-induced endothelial dysfunction
Maricene Sabha BSc, José Eduardo Tanus-Santos MD, PhD, Juan Carlos Yugar Toledo MD, Máira Cittadino BSc, João Carlos Rocha MD and Heitor Moreno Jr MD, PhD
Clin Pharmacol Ther 68: 167-174; doi:10.1067/mcp.2000.108851
A pharmacodynamic Markov mixed-effect model for the effect of temazepam on sleep
Mats O. Karlsson PhD, Rik C. Schoemaker PhD, Bob Kemp PhD, Adam F. Cohen MD, PhD, Joop M.A. van Gerven MD, PhD, Bert Tuk PhD, Carl C. Peck MD, PhD and Meindert Danhof PhD
Clin Pharmacol Ther 68: 175-188; doi:10.1067/mcp.2000.108669
Pharmacogenetics and Genomics
Slow chloroguanide metabolism in Tanzanians compared with white subjects and Asian subjects confirms a decreased CYP2C19 activity in relation to genotype
Karin Herrlin MD, Amos Y. Massele MD, PhD, Gerard Rimoy MD, PhD, Christina Alm RN, Margareta Rais Eng, Örjan Ericsson PhD, Leif Bertilsson PhD and Lars L. Gustafsson MD, PhD
Clin Pharmacol Ther 68: 189-198; doi:10.1067/mcp.2000.108583
Quinidine as a probe for CYP3A4 activity: Intrasubject variability and lack of correlation with probe-based assays for CYP1A2, CYP2C9, CYP2C19, and CYP2D6
Per Damkier MD and Kim Brøsen MD
Clin Pharmacol Ther 68: 199-209; doi:10.1067/mcp.2000.108532
Thiopurine methyltransferase polymorphic tandem repeat: Genotype-phenotype correlation analysis
Lan Yan MD, PhD, Shuichen Zhang MD, Bianca Eiff BS, Carol L. Szumlanski BS, Melody Powers MT, John F. O'Brien PhD and Richard M. Weinshilboum MD
Clin Pharmacol Ther 68: 210-219; doi:10.1067/mcp.2000.108674
