TABLE OF CONTENTS
Volume 67, Issue 3 (March 2000)
Pharmacokinetics and Drug Disposition |
Pharmacodynamics and Drug Action |
Pharmacoepidemiology and Drug Utilization |
Clinical Pharmacology Grand Rounds |
USAN Council
Commentaries
Are we treating health or physical appearance when we prescribe drugs for obesity?
Marcus M. Reidenberg MD
Clin Pharmacol Ther 67: 193-195; doi:10.1067/mcp.2000.105242
Assessment and reporting of clinical pharmacology information in drug labeling
Daniel A. Spyker PhD, MD, Elisa D. Harvey PhD, DVM, Brian E. Harvey MD, PhD, Alan M. Harvey MD, MBA, Barry H. Rumack MD, Carl C. Peck MD, Arthur J. Atkinson Jr MD, Raymond L. Woosley MD, PhD, Darrell R. Abernethy MD, PhD and Louis R. Cantilena MD, PhD
Clin Pharmacol Ther 67: 196-200; doi:10.1067/mcp.2000.104737
Pharmacokinetics and Drug Disposition
Relationship between time after intake of grapefruit juice and the effect on pharmacokinetics and pharmacodynamics of nisoldipine in healthy subjects
Hitomi Takanaga PhD, Ayako Ohnishi MS, Hideyasu Murakami MS, Hirotami Matsuo PhD, Shun Higuchi PhD, Akinori Urae MD, Shin Irie MD, Hidetoshi Furuie MD, PhD, Kyoko Matsukuma MD, Miyuki Kimura PhD, Koichi Kawano BS, Yoshimitsu Orii MS, Toshiaki Tanaka BS and Yasufumi Sawada PhD
Clin Pharmacol Ther 67: 201-214; doi:10.1067/mcp.2000.104215
Diltiazem and mibefradil increase the plasma concentrations and greatly enhance the adrenal-suppressant effect of oral methylprednisolone
Tiina Varis MD, Janne T. Backman MD, Kari T. Kivistö MD and Pertti J. Neuvonen MD
Clin Pharmacol Ther 67: 215-221; doi:10.1067/mcp.2000.104611
Effect of cimetidine and probenecid on pilsicainide renal clearance in humans
Tsuyoshi Shiga MD, PhD, Masayuki Hashiguchi PhD, Akinori Urae MD, Hiroshi Kasanuki MD, PhD and Tadaaki Rikihisa PhD
Clin Pharmacol Ther 67: 222-228; doi:10.1067/mcp.2000.104018
Target site concentrations after continuous infusion and bolus injection of cefpirome to healthy volunteers
Ursula Hollenstein MD, Martin Brunner MD, Bernhard X. Mayer PhD, Simon Delacher, Boban Erovic MD, Hans Georg Eichler MD, MSc and Markus Müller MD
Clin Pharmacol Ther 67: 229-236; doi:10.1067/mcp.2000.104266
The disposition of chloroquine and its main metabolite desethylchloroquine in volunteers with and without chloroquine-induced pruritus: Evidence for decreased chloroquine metabolism in volunteers with pruritus
O. G. Ademowo PhD, O. Sodeinde MD and O. Walker MD
Clin Pharmacol Ther 67: 237-241; doi:10.1067/mcp.2000.104257
Prediction of cyclosporine clearance in liver transplant recipients by the use of midazolam as a cytochrome P450 3A probe
Jean-Pierre Villeneuve MD, Lyne L'Ecuyer RN, Stéphane De Maeght MD and Pierre Bannon PhD
Clin Pharmacol Ther 67: 242-248; doi:10.1067/mcp.2000.104642
Nonlinear kinetics and pharmacologic response to mibefradil
Patrick du Souich MD, PhD, Jean-Guy Besner PhD, Jean-Paul Clozel MD, Horst A. Welker PhD, Marc Lefebvre PhD and Gilles Caillé PhD
Clin Pharmacol Ther 67: 249-257; doi:10.1067/mcp.2000.104616
Effect of age and smoking on in vivo CYP1A2, flavin-containing monooxygenase, and xanthine oxidase activities in Koreans: Determination by caffeine metabolism
Woon-Gye Chung PhD, Ju-Hee Kang MD, Chang-Shin Park PhD, Myung-Haeng Cho PhD and Young-Nam Cha PhD
Clin Pharmacol Ther 67: 258-266; doi:10.1067/mcp.2000.104617
The interaction of diltiazem with simvastatin
Omaima Mousa MD, D. Craig Brater MD, Kimberly J. Sundblad RN and Stephen D. Hall PhD
Clin Pharmacol Ther 67: 267-274; doi:10.1067/mcp.2000.104609
Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation
Peter T. Manyike PhD, Evan D. Kharasch MD, PhD, Thomas F. Kalhorn BS and John T. Slattery PhD
Clin Pharmacol Ther 67: 275-282; doi:10.1067/mcp.2000.104736
Paroxetine affects metoprolol pharmacokinetics and pharmacodynamics in healthy volunteers
Alex Hemeryck PharmD, Romain A. Lefebvre MD, PhD, Cindy De Vriendt Eng and Frans M. Belpaire PhD
Clin Pharmacol Ther 67: 283-291; doi:10.1067/mcp.2000.104788
Pharmacodynamics and Drug Action
Venous neuropeptide Y receptor responsiveness in patients with chronic heart failure
Qingping Feng MD, PhD, Michelle L. Lambert MSc, Ian D. Callow MSc and J. Malcolm O. Arnold MD, FACC
Clin Pharmacol Ther 67: 292-298; doi:10.1067/mcp.2000.104610
Venous responsiveness to norepinephrine in healthy subjects: Effects of single doses of 325 mg aspirin
T. Nancy Dzeka MSc, Peter Kuzminski BSc and J. Malcolm O. Arnold MD
Clin Pharmacol Ther 67: 299-304; doi:10.1067/mcp.2000.104943
Ex vivo–in vitro interaction between aspirin, clopidogrel, and the glycoprotein IIb/IIIa inhibitors abciximab and SR121566A
Ute Klinkhardt MD, Carl M. Kirchmaier MD, Dagmar Westrup BSc, Jochen Graff MD, Rene Mahnel, Hans Klaus Breddin MD and Sebastian Harder MD
Clin Pharmacol Ther 67: 305-313; doi:10.1067/mcp.2000.104613
Pharmacoepidemiology and Drug Utilization
Use of calcium antagonists and hemoglobin loss in hospitalized elderly patients: A cohort study
Giuseppe Zuccalà MD, Claudio Pedone MD, Alberto Cocchi MD, Marco Pahor MD, Luciana Carosella MD, Pierugo Carbonin MD, Roberto Bernabei MD and the Gruppo Italiano di Farmacoepidemiologia nell' Anziano (GIFA) investigators
Clin Pharmacol Ther 67: 314-322; doi:10.1067/mcp.2000.104787
Clinical Pharmacology Grand Rounds
Life-threatening 5-fluorouracil–like cardiac toxicity after treatment with 5-fluorocytosine
Christian Isetta MD, Rodolphe Garaffo PharmD, Gérard Bastian PhD, Jacques Jourdan MD, Marcel Baudouy MD and Gérard Milano PhD
Clin Pharmacol Ther 67: 323-325; doi:10.1067/mcp.2000.104643
New website announcement
Clin Pharmacol Ther 67: 328; doi:10.1053/cp.2000.v67.106487
