TABLE III

	Cmax (ng mL-1)		tmax (h)		Elimination t1/2 (h)		AUC(0–24) (ng mL-1 h)		AUC(0-) (ng mL-1 h)
	Water	Grapefruit juice	Water	Grapefruit juice	Water	Grapefruit juice	Water	Grapefruit juice	Water	Grapefruit juice
Pravastatin	45.3 28.0	42.6 25.3	1 (1–2)	2 (1–3)	2.0 0.6	1.7 0.4	111.7 68.1	102.8 49.6	112.3 66.3	103.0 48.4
% of control	100	94					100	92	100	92
Range		39–193						49–193		50–184
Pravastatin lactone	1.6 0.9	1.6 0.7	2 (0.5–2)	2 (2–3)	ND	ND	3.3 2.3	3.7 1.8	ND	ND
% of control	100	100					100	112
Range		47–265						45–439
Active HMG-CoA reductase inhibitors	49.4 32.1	41.9 21.2	1 (1–2)	2 (1–3)*	1.9 1.2	1.6 0.3	121.3 75.7	110.6 50.4	127.1 75.9	115.0 49.5
% of control	100	85					100	91	100	90
Range		45–200						52–181		52–180
Total HMG-CoA reductase inhibitors	47.9 26.3	43.1 21.4	1 (1–2)	2 (1–3)	1.2 0.4	1.5 0.4	110.4 66.3	103.3 48.2	116.8 68.0	113.3 49.3
% of control	100	90					100	94	100	97
Range		38–167						57–189		59–193

 Data are mean values SD; t_max data are given as median with range.

 C_max, Peak serum concentration; t_max, time to reach C_max; t_1/2, half-life; AUC(0–24), area under the serum concentration–time curve from 0 to 24 hours; AUC(0-), area under the serum concentration–time curve from time zero to infinity; ND, not determined; HMG-CoA, 3-hydroxy-3-methylglutaryl coenzyme A.

^*  P < .05 versus control phase (water).