TABLE OF CONTENTS
Volume 64, Issue 1 (July 1998)
Pharmacokinetics and Drug Disposition |
Pharmacodynamics and Drug Action |
Clinical Pharmacology Rounds |
Letters to the Editor |
USAN Council
Commentary
Expectations and the placebo effect in clinical drug trials: Why we should not turn a blind eye to unblinding, and other cautionary notes
Leora C. Swartzman PhD and Jacquelyn Burkell PhD
Clin Pharmacol Ther 64: 1-7; doi:10.1016/S0009-9236(98)90016-9
Pharmacokinetics and Drug Disposition
Selective effect of liver disease on the activities of specific metabolizing enzymes: Investigation of cytochromes P450 2C19 and 2D6
Adedayo Adedoyin PhD, Patricia A. Arns MD, W.O. Richards MD, Grant R. Wilkinson PhD and Robert A. Branch MD
Clin Pharmacol Ther 64: 8-17; doi:10.1016/S0009-9236(98)90017-0
Time course of enzyme induction in humans: Effect of pentobarbital on nortriptyline metabolism
Christer von Bahr MD, PhD, Eugen Steiner MD, PhD, Yuichi Koike MD, PhD and Johan Gabrielsson PhD
Clin Pharmacol Ther 64: 18-26; doi:10.1016/S0009-9236(98)90018-2
Pharmacokinetics of intravenous dynorphin A(1–13) in opioid-naive and opioid-treated human volunteers
Pedro L. Gambús MD, Thomas W. Schnider MD, Charles F. Minto MBChB, Elizabeth J. Youngs MD, Valerie Billard MD, William G. Brose MD, Günther Hochhaus PhD and Steven L. Shafer MD
Clin Pharmacol Ther 64: 27-38; doi:10.1016/S0009-9236(98)90019-4
Single-dose disulfiram does not inhibit CYP2A6 activity
Evan D. Kharasch MD, PhD, Douglas C. Hankins MA, Pamela J. Baxter PhD and Kenneth E. Thummel PhD
Clin Pharmacol Ther 64: 39-45; doi:10.1016/S0009-9236(98)90020-0
Isolation of a human thiopurine S-methyltransferase (TPMT) complementary DNA with a single nucleotide transition A719G (TPMT*3C) and its association with loss of TPMT protein and catalytic activity in humans
Thrina Loennechen PhD, Charles R. Yates PharmD, Michael Y. Fessing PhD, Mary V. Relling PharmD, Eugene Y. Krynetski PhD and William E. Evans PharmD
Clin Pharmacol Ther 64: 46-51; doi:10.1016/S0009-9236(98)90021-2
Inhibition of CYP2E1 by chlormethiazole as measured by chlorzoxazone pharmacokinetics in patients with alcoholism and in healthy volunteers
Chin B. Eap PhD, Christiane Schnyder MD, Jaques Besson MD, Line Savary and Thierry Buclin MD
Clin Pharmacol Ther 64: 52-57; doi:10.1016/S0009-9236(98)90022-4
Effect of itraconazole on the pharmacokinetics of atorvastatin
Teemu Kantola MB, Kari T. Kivistö MD and Pertti J. Neuvonen MD
Clin Pharmacol Ther 64: 58-65; doi:10.1016/S0009-9236(98)90023-6
Disposition and immunodynamics of basiliximab in liver allograft recipients
John Kovarik PharmD, Thomas Breidenbach PhD, Christophe Gerbeau PhD, Alex Korn PhD, Albrecht-Georg Schmidt MD and Björn Nashan MD
Clin Pharmacol Ther 64: 66-72; doi:10.1016/S0009-9236(98)90024-8
Pharmacodynamics and Drug Action
Metabolism and action of urodilatin infusion in healthy volunteers
Jan Carstens MD, Kaare T. Jensen MD and Erling B. Pedersen MD, DMSc
Clin Pharmacol Ther 64: 73-86; doi:10.1016/S0009-9236(98)90025-X
Dose-related cardiovascular and endocrine effects of transdermal nicotine
Shoshana Zevin MD, Peyton Jacob III PhD and Neal L. Benowitz MD
Clin Pharmacol Ther 64: 87-95; doi:10.1016/S0009-9236(98)90026-1
Differential responses of the heart and vasculature to chronic blood pressure reduction in essential hypertension
Anne Lafleche MD, Sylvie Gautier MD, Jirar Topouchian MD, Catherine S. Wilmet MD, Xavier Girerd MD, Michel E. Safar MD and Athanase Benetos MD
Clin Pharmacol Ther 64: 96-105; doi:10.1016/S0009-9236(98)90027-3
Population pharmacodynamic modeling of levodopa in patients with Parkinson's disease receiving entacapone
Iñaki F. Trocóniz PhD, Tarja H. Naukkarinen MSc, Hanna M. Ruottinen MD, Urpo K. Rinne MD, Ariel Gordin MD and Mats O. Karlsson PhD
Clin Pharmacol Ther 64: 106-116; doi:10.1016/S0009-9236(98)90028-5
Cerebrospinal fluid prostaglandins after systemic dipyrone intake
Micha Levy MD, Kay Brune MD, Ester Zylber-Katz PhD, Oren Cohen MD, Yoseph Caraco MD and Gerd Geisslinger PhD, MD
Clin Pharmacol Ther 64: 117-122; doi:10.1016/S0009-9236(98)90029-7
Clinical Pharmacology Rounds
Effect of clarithromycin on renal excretion of digoxin: Interaction with P-glycoprotein
Hiroko Wakasugi MS, Ikuko Yano PhD, Tatsuya Ito MS, Tohru Hashida BS, Takahiro Futami PhD, Ryuji Nohara MD, Shigetake Sasayama MD and Ken-ichi Inui PhD
Clin Pharmacol Ther 64: 123-128; doi:10.1016/S0009-9236(98)90030-3
Letters to the Editor
CYP3A4 and the erythromycin breath test
David Wagner PhD
Clin Pharmacol Ther 64: 129; doi:10.1016/S0009-9236(98)90031-5
Reply
David E. Smith PhD
Clin Pharmacol Ther 64: 130; doi:10.1016/S0009-9236(98)90032-7
