TABLE OF CONTENTS

Volume 61, Issue 3 (March 1997)

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Commentaries

Learning versus confirming in clinical drug development

Lewis B. Sheiner MD

Clin Pharmacol Ther 61: 275-291; doi:10.1016/S0009-9236(97)90160-0

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Pharmacokinetics and Drug Disposition

Dietary salt increases first-pass elimination of oral quinidine

Dawood Darbar MD, Simonetta Dell'Orto MD, Klaus Mörike MD, Grant R. Wilkinson PhD and Dan M. Roden MD

Clin Pharmacol Ther 61: 292-300; doi:10.1016/S0009-9236(97)90161-2

Population pharmacokinetics and pharmacodynamics of pegylated-liposomal doxorubicin in patients with AIDS-related Kaposi's sarcoma

Michael A. Amantea PharmD, Alan Forrest PharmD, Donald W. Northfelt MD and Richard Mamelok MD

Clin Pharmacol Ther 61: 301-311; doi:10.1016/S0009-9236(97)90162-4

Bromfenac disposition in patients with impaired kidney function

James C. Ermer MS, Joseph P. Boni PhD, William H. Cevallos PhD, Sheryl DeCleene RN, Peter Burghart MS, Michael R. Rudnick MD, Richard J. Fruncillo MD, PhD, Jeffrey S. Berns MD and Raphael M. Cohen MD

Clin Pharmacol Ther 61: 312-318; doi:10.1016/S0009-9236(97)90163-6

Imipramine demethylation in vivo: Impact of CYP1A2, CYP2C19, and CYP3A4

Hanne Madsen MD, Birgitte Buur Rasmussen MSc and Kim Brøsen MD

Clin Pharmacol Ther 61: 319-324; doi:10.1016/S0009-9236(97)90164-8

Pharmacokinetics and pharmacodynamics of cetirizine in infants and toddlers

Václav S caronpic caronák MD, PhD, Isidore Dab MD, PhD, Réginald Hulhoven MD, PhD, Jean-Pierre Desager PhD, Marie Klánová MD, Marc de Longueville MD and Carl Harvengt MD, PhD

Clin Pharmacol Ther 61: 325-330; doi:10.1016/S0009-9236(97)90165-X

Age and cytochrome P450-linked drug metabolism in humans: An analysis of 226 subjects with equal histopathologic conditions

Eero A. Sotaniemi MD, PhD, Arno J. Arranto MD, PhD, Olavi Pelkonen MD, PhD and Markku Pasanen MD, PhD

Clin Pharmacol Ther 61: 331-339; doi:10.1016/S0009-9236(97)90166-1

Pharmacokinetics of nicotine carbomer enemas: A new treatment modality for ulcerative colitis

John T. Green MB, BCh, Gareth A. O. Thomas MD, John Rhodes MD, Brian K. Evans PhD, Michael A. H. Russell BM, BCh, Colin Feyerabend PhD, Grant S. Fuller BSc, Robert G. Newcombe PhD and William J. Sandborn MD

Clin Pharmacol Ther 61: 340-348; doi:10.1016/S0009-9236(97)90167-3

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Pharmacodynamics and Drug Action

Effects of tobacco smoking on human ocular smooth pursuit

Edward F. Domino MS, MD, Li Song Ni MS and Huilei Zhang BS

Clin Pharmacol Ther 61: 349-359; doi:10.1016/S0009-9236(97)90168-5

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Clinical Trials and Therapeutics

Single-dose subcutaneous administration of recombinant human parathyroid hormone [rhPTH(1–84)] in healthy postmenopausal volunteers

Hendrik Reinier Schwieter PhD, Edwin W. J. Groen MD, Frans A. E. Sollie PharmD and Jan H. G. Jonkman PhD

Clin Pharmacol Ther 61: 360-376; doi:10.1016/S0009-9236(97)90169-7

The triangular test to assess the efficacy of metoclopramide in gastroesophageal reflux

Eric Bellissant MD, PhD, Jean-François Duhamel MD, Marcel Guillot MD, Ann Pariente-Khayat MD, George Olive MD, PharmD and Gerard Pons MD, PhD

Clin Pharmacol Ther 61: 377-384; doi:10.1016/S0009-9236(97)90170-3

Inhibition of cholesterol absorption with CP-148,623 lowers serum cholesterol in humans

William S. Harris PhD, Sheryl L. Windsor  MT (ASCP), Fran A. Newton MS and Robert A. Gelfand MD

Clin Pharmacol Ther 61: 385-389; doi:10.1016/S0009-9236(97)90171-5

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USAN Council

List No. 391: New Names

Clin Pharmacol Ther 61: 390-393; doi:10.1016/S0009-9236(97)90172-7

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Books Received

Books Received

Clin Pharmacol Ther 61: 394; doi:10.1016/S0009-9236(97)90173-9

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