TABLE OF CONTENTS

Volume 33, Issue 6 (June 1983)

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Commentary

New drug development during and after a period of regulatory change: Clinical research activity of major united states pharmacxeutical firms, 1958 to 1979

Maureen S May PhD, William M Wardell MD, PhD and Louis Lasagna MD Rochester, N.Y.

Clin Pharmacol Ther 33: 691-700; doi:10.1038/clpt.1983.95

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Original Articles

Hemodynamics and leg muscle metabolism at rest and during exercise in young healthy men after prenalterol

Ulf Dahlström MD, Jan-Henrik Atterhög MD and Lennart Jorfeldt MD Linköping, Sweden

Clin Pharmacol Ther 33: 701-709; doi:10.1038/clpt.1983.96

Blood pressure and plasma norepinephrine concentrations after endogenous norepinephrine release by tyramine

A J I Scriven MB, C T Dollery MB, M B Murphy MB, I Macquin MD and M J Brown MB London, England

Clin Pharmacol Ther 33: 710-716; doi:10.1038/clpt.1983.97

Digitoxin kinetics and renal excretion in children

Anne Larsen MD and Liv Storstein MD Oslo, Norway

Clin Pharmacol Ther 33: 717-726; doi:10.1038/clpt.1983.98

Cardiac muscle mass during vasodilation therapy of hypertension

Jan I M Drayer MD, Julius M Gardin MD, Michael A Weber MD and Wilbert S Aronow MD Irvine and Long Beach, Calif., and Omaha, Neb.

Clin Pharmacol Ther 33: 727-732; doi:10.1038/clpt.1983.99

Constant kinetics and constant concentration-effect relationship during long-term beta3-blockade with pindolol

Renato L Galeazzi MD, Mauro Pirovino MD and Peter Weidmann MD Berne, Switzerland

Clin Pharmacol Ther 33: 733-740; doi:10.1038/clpt.1983.100

Antihypertensive and metabolic effects of a new converting enzyme inhibitor, enalapril

Steven G Chrysant MD, Ronald D Brown MD, David C Kern MD and Janet L Brown BS, RN Kansas City, Kan., and Oklahoma City, Okla.

Clin Pharmacol Ther 33: 741-746; doi:10.1038/clpt.1983.101

Isosorbide dinitrate kinetics and dynamics after intravenous, sublingual, and percutaneous dosing in angina

R A Morrison PhD, U.-W Wiegand PhD, E Jähnchen MD, D Höhmann MD, H Bechtold MD, T Meinertz MD and H.-L Fung PhD Buffalo, N.Y., and Mainz, Germany

Clin Pharmacol Ther 33: 747-756; doi:10.1038/clpt.1983.102

Mianserin kinetics in depressed patients

Pavel D Hrdina MD, PhD, Yvon D Lapierre MD, Brent Mclntosh and L K Oyewumi MD Ottawa, Ontario, Canada

Clin Pharmacol Ther 33: 757-762; doi:10.1038/clpt.1983.103

Tricyclic antidepressants and supine, standing, and exercise plasma norepinephrine levels

Richard C Veith MD, Murray A Raskind MD, Robert F Barnes MD, Gail Gumbrecht, James L Ritchie MD and Jeffrey B Halter MD Seattle, Wash.

Clin Pharmacol Ther 33: 763-769; doi:10.1038/clpt.1983.104

Caffeine metabolism and coffee-attributed sleep disturbances

Micha Levy MD and Ester Zylber-Katz PhD Jerusalem, Israel

Clin Pharmacol Ther 33: 770-775; doi:10.1038/clpt.1983.105

Platelet alpha-adrenergic receptors in obesity: Alteration with weight loss

Pavur R Sundaresan MD, PhD, Michael Weintraub MD, Linda A Hershey MD, PhD, Bruce H Kroening BS, Jeffrey D Hasday MD and Shailesh P Banerjee PhD Rochester, N.Y.

Clin Pharmacol Ther 33: 776-785; doi:10.1038/clpt.1983.106

Placental transfer and maternal midazolam kinetics

J Kanto MD, S Sjövall MD, R Erkkola MD, J-J Himberg MD, PhD and L Kangas MSc Helsinki and Turku, Finland

Clin Pharmacol Ther 33: 786-791; doi:10.1038/clpt.1983.107

Gallamine disposition in open-heart surgery involving cardiopulmonary bypass

Colin A Shanks MD, Iqbal M Ramzan PhD, Judy S M Walker Dip Pharm., (NZ) and Kenneth F Brown PhD Sydney, Australia

Clin Pharmacol Ther 33: 792-799; doi:10.1038/clpt.1983.108

Effects of cigarette smoking and oral nicotine on hand tremor

Saul M  Shiffman PhD, Ellen R Gritz PhD, Joan Maltese PhD, Monroe A Lee, Nina G Schneider PhD and Murray E Jarvik MD, PhD Los Angeles, Calif., and Tampa, Fla.

Clin Pharmacol Ther 33: 800-805; doi:10.1038/clpt.1983.109

Cigarette smoking and subjective response in alcoholics: Effects of pentobarbital

Jack E Henningfield PhD, Larry D Chait PhD and Roland R Griffiths PhD Baltimore, Md.

Clin Pharmacol Ther 33: 806-812; doi:10.1038/clpt.1983.110

Diflunisal disposition and hypouricemic response in osteoarthritis

Peter J Meffin PhD, P M Brooks MD, J Bertouch MBBS, J R Veenendaal MApplSci and B J Harrington Dip Appl Sci Bedford Park, Australia

Clin Pharmacol Ther 33: 813-821; doi:10.1038/clpt.1983.111

Effect of probenecid on dyphylline elimination

David C May MD, PhD and Charles H Jarboe PhD Louisville, Ky.

Clin Pharmacol Ther 33: 822-825; doi:10.1038/clpt.1983.112

Treatment of noninsulin-dependent diabetes mellitus with enzyme inducers

Eero A Sotaniemi MD, Arno J Arranto MD, Seppo Sutinen MD, Jari H Stengård MD and Sirkka Sutinen MA Oulu, Finland

Clin Pharmacol Ther 33: 826-835; doi:10.1038/clpt.1983.113

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Erratum

Erratum FREE

Clin Pharmacol Ther 33: 835; doi:10.1038/clpt.1983.114

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USAN Council

List No. 237

Clin Pharmacol Ther 33: 836-837; doi:10.1038/clpt.1983.115

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Notes of the American Society for Clinical Pharmacology and Therapeutics

Notes of the American Society for Clinical Pharmacology and Therapeutics

Clin Pharmacol Ther 33: 838; doi:10.1038/clpt.1983.116

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Index to Volume 33

Author index

Clin Pharmacol Ther 33: 841-847; doi:10.1038/clpt.1983.117

Subject index

Clin Pharmacol Ther 33: 848-858; doi:10.1038/clpt.1983.118

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