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Chemical Biology

  • Article

    Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited

    Brian P English, Wei Min, Antoine M van Oijen, Kang Taek Lee, Guobin Luo, Hongye Sun, Binny J Cherayil, S C Kou & X Sunney Xie

    doi:10.1038/nchembio759

    Nature Chemical Biology 2; 87 - 94 (2006)

    Published online: 25 December 2005

    Abstract | Full Text | PDF (486K)

  • Article

    Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro

    Henry E Pelish, Jeffrey R Peterson, Susana B Salvarezza, Enrique Rodriguez-Boulan, Ji-Long Chen, Mark Stamnes, Eric Macia, Yan Feng, Matthew D Shair & Tomas Kirchhausen

    doi:10.1038/nchembio751

    Nature Chemical Biology 2; 39 - 46 (2006)

    Published online: 20 November 2005

    Abstract | Full Text | PDF (749K)

  • Brief Communication

    Purmorphamine activates the Hedgehog pathway by targeting Smoothened

    Surajit Sinha & James K Chen

    doi:10.1038/nchembio753

    Nature Chemical Biology 2; 29 - 30 (2006)

    Published online: 20 November 2005

    Abstract | Full Text | PDF (193K)

  • Brief Communication

    Direct transfer of extended groups from synthetic cofactors by DNA methyltransferases

    Christian Dalhoff, Graz caronvydas Lukinavic caronius, Saulius Klimas breveauskas & Elmar Weinhold

    doi:10.1038/nchembio754

    Nature Chemical Biology 2; 31 - 32 (2006)

    Published online: 27 November 2005

    Abstract | Full Text | PDF (150K)

  • Letter

    Actin microfilament aggregation induced by withaferin A is mediated by annexin II

    Ryan R Falsey, Marilyn T Marron, G M Kamal B Gunaherath, Nikhil Shirahatti, Daruka Mahadevan, A A Leslie Gunatilaka & Luke Whitesell

    doi:10.1038/nchembio755

    Nature Chemical Biology 2; 33 - 38 (2006)

    Published online: 11 December 2005

    Abstract | Full Text | PDF (362K)

  • Article

    Allosteric control of an ionotropic glutamate receptor with an optical switch

    Matthew Volgraf, Pau Gorostiza, Rika Numano, Richard H Kramer, Ehud Y Isacoff & Dirk Trauner

    doi:10.1038/nchembio756

    Nature Chemical Biology 2; 47 - 52 (2006)

    Published online: 11 December 2005

    Abstract | Full Text | PDF (358K)

  • Brief Communication

    Fluorescent sensors for rapid monitoring of intracellular cGMP

    Viacheslav O Nikolaev, Stepan Gambaryan & Martin J Lohse

    doi:10.1038/nmeth816

    Nature Methods 3; 23 - 25 (2006)

    Published online: 20 December 2005

    Abstract | Full Text | PDF (176K)

  • Article

    The nitrodibenzofuran chromophore: a new caging group for ultra-efficient photolysis in living cells

    Atsuya Momotake, Nicolas Lindegger, Ernst Niggli, Robert J Barsotti & Graham C R Ellis-Davies

    doi:10.1038/nmeth821

    Nature Methods 3; 35 - 40 (2006)

    Published online: 20 December 2005

    Abstract | Full Text | PDF (278K)

  • Letter

    Monocarboxylate transporter MCT1 is a target for immunosuppression

    Clare M Murray, Raymond Hutchinson, John R Bantick, Graham P Belfield, Amanda D Benjamin, Diana Brazma, Robert V Bundick, I David Cook, Robert I Craggs, Susan Edwards, Leslie R Evans, Richard Harrison, Elain Holness, Andrew P Jackson, Clive G Jackson, Lee P Kingston, Matthew W D Perry, Andrew R J Ross, Paul A Rugman, Sasvinder S Sidhu, Michael Sullivan, David A Taylor-Fishwick, P Craig Walker, Yvonne M Whitehead, David J Wilkinson, Andrew Wright & David K Donald

    doi:10.1038/nchembio744

    Nature Chemical Biology 1; 371 - 376 (2005)

    Published online: 30 October 2005

    Abstract | Full Text | PDF (315K)

  • Letter

    C3-symmetric peptide scaffolds are functional mimetics of trimeric CD40L

    Sylvie Fournel, Sébastien Wieckowski, Weimin Sun, Nathalie Trouche, Hélène Dumortier, Alberto Bianco, Olivier Chaloin, Mohammed Habib, Jean-Christophe Peter, Pascal Schneider, Bernard Vray, René E Toes, Rienk Offringa, Cornelis J M Melief, Johan Hoebeke & Gilles Guichard

    doi:10.1038/nchembio746

    Nature Chemical Biology 1; 377 - 382 (2005)

    Published online: 06 November 2005

    Abstract | Full Text | PDF (636K)

  • Article

    Analysis of drug-induced effect patterns to link structure and side effects of medicines

    Anton F Fliri, William T Loging, Peter F Thadeio & Robert A Volkmann

    doi:10.1038/nchembio747

    Nature Chemical Biology 1; 389 - 397 (2005)

    Published online: 06 November 2005

    Abstract | Full Text | PDF (699K)

  • Letter

    Actin is the primary cellular receptor of bistramide A

    Alexander V Statsuk, Ruoli Bai, Jeremy L Baryza, Vishal A Verma, Ernest Hamel, Paul A Wender & Sergey A Kozmin

    doi:10.1038/nchembio748

    Nature Chemical Biology 1; 383 - 388 (2005)

    Published online: 13 November 2005

    Abstract | Full Text | PDF (332K)

  • Letter

    Small molecules that delay S phase suppress a zebrafish bmyb mutant

    Howard M Stern, Ryan D Murphey, Jennifer L Shepard, James F Amatruda, Christian T Straub, Kathleen L Pfaff, Gerhard Weber, John A Tallarico, Randall W King & Leonard I Zon

    doi:10.1038/nchembio749

    Nature Chemical Biology 1; 366 - 370 (2005)

    Published online: 13 November 2005

    Abstract | Full Text | PDF (401K)

  • Perspective

    Photochemical tools for remote control of ion channels in excitable cells

    Richard H Kramer, James J Chambers & Dirk Trauner

    doi:10.1038/nchembio750

    Nature Chemical Biology 1; 360 - 365 (2005)

    Published online: 16 November 2005

    Abstract | Full Text | PDF (410K)

  • Letter

    Cistrans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel

    Sarah C. R. Lummis, Darren L. Beene, Lori W. Lee, Henry A. Lester, R. William Broadhurst & Dennis A. Dougherty

    doi:10.1038/nature04130

    Nature 438; 248 - 252 (2005)

    Abstract | Full Text | PDF (420K)

  • Letter

    Intrinsic dynamics of an enzyme underlies catalysis

    Elan Z. Eisenmesser, Oscar Millet, Wladimir Labeikovsky, Dmitry M. Korzhnev, Magnus Wolf-Watz, Daryl A. Bosco, Jack J. Skalicky, Lewis E. Kay & Dorothee Kern

    doi:10.1038/nature04105

    Nature 438; 117 - 121 (2005)

    Abstract | Full Text | PDF (485K)

  • Letter

    Evolution of glutamate interactions during binding to a glutamate receptor

    Qing Cheng, Mei Du, Gomathi Ramanoudjame & Vasanthi Jayaraman

    doi:10.1038/nchembio738

    Nature Chemical Biology 1; 329 - 332 (2005)

    Published online: 25 September 2005

    Abstract | Full Text | PDF (295K)

  • Letter

    Mixture of new sulfated steroids functions as a migratory pheromone in the sea lamprey

    Peter W Sorensen, Jared M Fine, Vadims Dvornikovs, Christopher S Jeffrey, Feng Shao, Jizhou Wang, Lance A Vrieze, Kari R Anderson & Thomas R Hoye

    doi:10.1038/nchembio739

    Nature Chemical Biology 1; 324 - 328 (2005)

    Published online: 02 October 2005

    Abstract | Full Text | PDF (267K)

  • Letter

    A torque component in the kinesin-1 power stroke

    Junichiro Yajima & Robert A Cross

    doi:10.1038/nchembio740

    Nature Chemical Biology 1; 338 - 341 (2005)

    Published online: 09 October 2005

    Abstract | Full Text | PDF (254K)

  • Article

    Entropy rectifies the Brownian steps of kinesin

    Yuichi Taniguchi, Masayoshi Nishiyama, Yoshiharu Ishii & Toshio Yanagida

    doi:10.1038/nchembio741

    Nature Chemical Biology 1; 342 - 347 (2005)

    Published online: 09 October 2005

    Abstract | Full Text | PDF (719K)

  • Letter

    Host sphingolipid biosynthesis as a target for hepatitis C virus therapy

    Hiroshi Sakamoto, Koichi Okamoto, Masahiro Aoki, Hideyuki Kato, Asao Katsume, Atsunori Ohta, Takuo Tsukuda, Nobuo Shimma, Yuko Aoki, Mikio Arisawa, Michinori Kohara & Masayuki Sudoh

    doi:10.1038/nchembio742

    Nature Chemical Biology 1; 333 - 337 (2005)

    Published online: 16 October 2005

    Abstract | Full Text | PDF (325K)

  • Article

    Rapid neurotransmitter uncaging in spatially defined patterns

    Shy Shoham, Daniel H O'Connor, Dmitry V Sarkisov & Samuel S-H Wang

    doi:10.1038/nmeth793

    Nature Methods 2; 837 - 843 (2005)

    Published online: 21 October 2005

    Abstract | Full Text | PDF (699K)

  • Brief Communication

    K+ waves in brain cortex visualized using a long-wavelength K+-sensing fluorescent indicator

    Prashant Padmawar, Xiaoming Yao, Orin Bloch, Geoffrey T Manley & A S Verkman

    doi:10.1038/nmeth801

    Nature Methods 2; 825 - 827 (2005)

    Published online: 21 October 2005

    Abstract | Full Text | PDF (250K)

  • Article

    Evanescent-field fluorescence-assisted lectin microarray: a new strategy for glycan profiling

    Atsushi Kuno, Noboru Uchiyama, Shiori Koseki-Kuno, Youji Ebe, Seigo Takashima, Masao Yamada & Jun Hirabayashi

    doi:10.1038/nmeth803

    Nature Methods 2; 851 - 856 (2005)

    Published online: 21 October 2005

    Abstract | Full Text | PDF (407K)

  • Article

    Versatile fluorescent derivatization of glycans for glycomic analysis

    Baoyun Xia, Ziad S Kawar, Tongzhong Ju, Richard A Alvarez, Goverdhan P Sachdev & Richard D Cummings

    doi:10.1038/nmeth808

    Nature Methods 2; 845 - 850 (2005)

    Published online: 21 October 2005

    Abstract | Full Text | PDF (349K)

  • Article

    Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus

    Per H. Mygind, Rikke L. Fischer, Kirk M. Schnorr, Mogens T. Hansen, Carsten P. Sönksen, Svend Ludvigsen, Dorotea Raventós, Steen Buskov, Bjarke Christensen, Leonardo De Maria, Olivier Taboureau, Debbie Yaver, Signe G. Elvig-Jørgensen, Marianne V. Sørensen, Bjørn E. Christensen, Søren Kjærulff, Niels Frimodt-Moller, Robert I. Lehrer, Michael Zasloff & Hans-Henrik Kristensen

    doi:10.1038/nature04051

    Nature 437; 975 - 980 (2005)

    Abstract | Full Text | PDF (398K)

  • Letter

    A carbohydrate-antioxidant hybrid polymer reduces oxidative damage in spermatozoa and enhances fertility

    Craig Fleming, André Maldjian, Daniel Da Costa, Attvinder K Rullay, David M Haddleton, Justin St John, Paul Penny, Raymond C Noble, Neil R Cameron & Benjamin G Davis

    doi:10.1038/nchembio730

    Nature Chemical Biology 1; 270 - 274 (2005)

    Published online: 04 September 2005

    Abstract | Full Text | PDF (480K)

  • Letter

    Discovery of a new peptide natural product by Streptomyces coelicolor genome mining

    Sylvie Lautru, Robert J Deeth, Lianne M Bailey & Gregory L Challis

    doi:10.1038/nchembio731

    Nature Chemical Biology 1; 265 - 269 (2005)

    Published online: 11 September 2005

    Abstract | Full Text | PDF (217K)

  • Article

    Preferential synapsis of loxP sites drives ordered strand exchange in Cre-loxP site-specific recombination

    Kaushik Ghosh, Chi-Kong Lau, Kushol Gupta & Gregory D Van Duyne

    doi:10.1038/nchembio733

    Nature Chemical Biology 1; 275 - 282 (2005)

    Published online: 11 September 2005

    Abstract | Full Text | PDF (377K)

  • Article

    Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues

    Nathan S Bryan, Bernadette O Fernandez, Selena M Bauer, Maria Francisca Garcia-Saura, Alexandra B Milsom, Tienush Rassaf, Ronald E Maloney, Ajit Bharti, Juan Rodriguez & Martin Feelisch

    doi:10.1038/nchembio734

    Nature Chemical Biology 1; 290 - 297 (2005)

    Published online: 18 September 2005

    Abstract | Full Text | PDF (276K)

  • Article

    Neuronal synapse interaction reconstituted between live cells and supported lipid bilayers

    Sophie Pautot, Hanson Lee, Ehud Y Isacoff & Jay T Groves

    doi:10.1038/nchembio737

    Nature Chemical Biology 1; 283 - 289 (2005)

    Published online: 18 September 2005

    Abstract | Full Text | PDF (470K)

  • Article

    Trapped in action: direct visualization of DNA methyltransferase activity in living cells

    Lothar Schermelleh, Fabio Spada, Hariharan P Easwaran, Kourosh Zolghadr, Jean B Margot, M Cristina Cardoso & Heinrich Leonhardt

    doi:10.1038/nmeth794

    Nature Methods 2; 751 - 756 (2005)

    Published online: 22 September 2005

    Abstract | Full Text | PDF (489K)

  • Article

    Inhibiting transcription of chromosomal DNA with antigene peptide nucleic acids

    Bethany A Janowski, Kunihiro Kaihatsu, Kenneth E Huffman, Jacob C Schwartz, Rosalyn Ram, Daniel Hardy, Carole R Mendelson & David R Corey

    doi:10.1038/nchembio724

    Nature Chemical Biology 1; 210 - 215 (2005)

    Published online: 31 July 2005

    Abstract | Full Text | PDF (313K)

  • Article

    Inhibiting gene expression at transcription start sites in chromosomal DNA with antigene RNAs

    Bethany A Janowski, Kenneth E Huffman, Jacob C Schwartz, Rosalyn Ram, Daniel Hardy, David S Shames, John D Minna & David R Corey

    doi:10.1038/nchembio725

    Nature Chemical Biology 1; 216 - 222 (2005)

    Published online: 31 July 2005

    Abstract | Full Text | PDF (288K)

  • Letter

    Imaging nanometer domains of bold beta-adrenergic receptor complexes on the surface of cardiac myocytes

    Anatoli Ianoul, Donna D Grant, Yanouchka Rouleau, Mahmud Bani-Yaghoub, Linda J Johnston & John Paul Pezacki

    doi:10.1038/nchembio726

    Nature Chemical Biology 1; 196 - 202 (2005)

    Published online: 07 August 2005

    Abstract | Full Text | PDF (582K)

  • Article

    Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors

    Valerian E Kagan, Vladimir A Tyurin, Jianfei Jiang, Yulia Y Tyurina, Vladimir B Ritov, Andrew A Amoscato, Anatoly N Osipov, Natalia A Belikova, Alexandr A Kapralov, Vidisha Kini, Irina I Vlasova, Qing Zhao, Meimei Zou, Peter Di, Dimitry A Svistunenko, Igor V Kurnikov & Gregory G Borisenko

    doi:10.1038/nchembio727

    Nature Chemical Biology 1; 223 - 232 (2005)

    Published online: 14 August 2005

    Abstract | Full Text | PDF (508K)

  • Letter

    Dynamic imaging of protease activity with fluorescently quenched activity-based probes

    Galia Blum, Stefanie R Mullins, Kinneret Keren, Marko Fonovic caron, Christopher Jedeszko, Mark J Rice, Bonnie F Sloane & Matthew Bogyo

    doi:10.1038/nchembio728

    Nature Chemical Biology 1; 203 - 209 (2005)

    Published online: 14 August 2005

    Abstract | Full Text | PDF (366K)

  • Article

    A streamlined platform for high-content functional proteomics of primary human specimens

    Nadim Jessani, Sherry Niessen, BinQing Q Wei, Monica Nicolau, Mark Humphrey, Youngran Ji, Wonshik Han, Dong-Young Noh, John R Yates, III, Stefanie S Jeffrey & Benjamin F Cravatt

    doi:10.1038/nmeth778

    Nature Methods 2; 691 - 697 (2005)

    Published online: 23 August 2005

    Abstract | Full Text | PDF (370K)

  • Letter

    Mycobactin-mediated iron acquisition within macrophages

    Minkui Luo, Evgeny A Fadeev & John T Groves

    doi:10.1038/nchembio717

    Nature Chemical Biology 1; 149 - 153 (2005)

    Published online: 03 July 2005

    Abstract | Full Text | PDF (308K)

  • Letter

    High-throughput assays for promiscuous inhibitors

    Brian Y Feng, Anang Shelat, Thompson N Doman, R Kip Guy & Brian K Shoichet

    doi:10.1038/nchembio718

    Nature Chemical Biology 1; 146 - 148 (2005)

    Published online: 03 July 2005

    Abstract | Full Text | PDF (229K)

  • Article

    A network of orthogonal ribosomedotmRNA pairs

    Oliver Rackham & Jason W Chin

    doi:10.1038/nchembio719

    Nature Chemical Biology 1; 159 - 166 (2005)

    Published online: 17 July 2005

    Abstract | Full Text | PDF (548K)

  • Letter

    Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine

    Douglas A Mitchell & Michael A Marletta

    doi:10.1038/nchembio720

    Nature Chemical Biology 1; 154 - 158 (2005)

    Published online: 10 July 2005

    Abstract | Full Text | PDF (235K)

  • Brief Communication

    Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9

    Dorothea Greiner, Tiziana Bonaldi, Ragnhild Eskeland, Ernst Roemer & Axel Imhof

    doi:10.1038/nchembio721

    Nature Chemical Biology 1; 143 - 145 (2005)

    Published online: 17 July 2005

    Abstract | Full Text | PDF (179K)

  • Article

    Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter

    Anh Tuân Phan, Vitaly Kuryavyi, Hai Yan Gaw & Dinshaw J Patel

    doi:10.1038/nchembio723

    Nature Chemical Biology 1; 167 - 173 (2005)

    Published online: 17 July 2005

    Abstract | Full Text | PDF (738K)

  • Letter

    Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1

    Jürgen Besemer, Hanna Harant, Shirley Wang, Berndt Oberhauser, Katharina Marquardt, Carolyn A. Foster, Erwin P. Schreiner, Jan E. de Vries, Christiane Dascher-Nadel & Ivan J. D. Lindley

    doi:10.1038/nature03670

    Nature 436; 290 - 293 (2005)

    Abstract | Full Text | PDF (398K)

  • Letter

    A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum

    Jennifer L. Garrison, Eric J. Kunkel, Ramanujan S. Hegde & Jack Taunton

    doi:10.1038/nature03821

    Nature 436; 285 - 289 (2005)

    Abstract | Full Text | PDF (489K)

  • Article

    Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

    Alexei Degterev, Zhihong Huang, Michael Boyce, Yaqiao Li, Prakash Jagtap, Noboru Mizushima, Gregory D Cuny, Timothy J Mitchison, Michael A Moskowitz & Junying Yuan

    doi:10.1038/nchembio711

    Nature Chemical Biology 1; 112 - 119 (2005)

    Published online: 29 May 2005

    Abstract | Full Text | PDF (509K)

  • Article

    RNA flexibility in the dimerization domain of a gamma retrovirus

    Christopher S Badorrek & Kevin M Weeks

    doi:10.1038/nchembio712

    Nature Chemical Biology 1; 104 - 111 (2005)

    Published online: 05 June 2005

    Abstract | Full Text | PDF (442K)

  • Letter

    Homomultimeric complexes of CD22 in B cells revealed by protein-glycan cross-linking

    Shoufa Han, Brian E Collins, Per Bengtson & James C Paulson

    doi:10.1038/nchembio713

    Nature Chemical Biology 1; 93 - 97 (2005)

    Published online: 12 June 2005

    Abstract | Full Text | PDF (365K)

  • Letter

    Linking agonist binding to histamine H1 receptor activation

    Aldo Jongejan, Martijn Bruysters, Juan A Ballesteros, Eric Haaksma, Remko A Bakker, Leonardo Pardo & Rob Leurs

    doi:10.1038/nchembio714

    Nature Chemical Biology 1; 98 - 103 (2005)

    Published online: 19 June 2005

    Abstract | Full Text | PDF (434K)

  • Brief Communication

    Multiphoton excitation–evoked chromophore-assisted laser inactivation using green fluorescent protein

    Takuji Tanabe, Masahito Oyamada, Katsumasa Fujita, Ping Dai, Hideo Tanaka & Tetsuro Takamatsu

    doi:10.1038/nmeth770

    Nature Methods ; 503 - 505 (2005)

    Published online: 22 June 2005

    Abstract | Full Text | PDF (331K)

  • Letter

    An inhibitor of Bcl-2 family proteins induces regression of solid tumours

    Tilman Oltersdorf, Steven W. Elmore, Alexander R. Shoemaker, Robert C. Armstrong, David J. Augeri, Barbara A. Belli, Milan Bruncko, Thomas L. Deckwerth, Jurgen Dinges, Philip J. Hajduk, Mary K. Joseph, Shinichi Kitada, Stanley J. Korsmeyer, Aaron R. Kunzer, Anthony Letai, Chi Li, Michael J. Mitten, David G. Nettesheim, ShiChung Ng, Paul M. Nimmer, Jacqueline M. O'Connor, Anatol Oleksijew, Andrew M. Petros, John C. Reed, Wang Shen, Stephen K. Tahir, Craig B. Thompson, Kevin J. Tomaselli, Baole Wang, Michael D. Wendt, Haichao Zhang, Stephen W. Fesik & Saul H. Rosenberg

    doi:10.1038/nature03579

    Nature 435; 677 - 681 (2005)

    Published online: 15 May 2005

    Abstract | Full Text | PDF (362K)

  • Article

    General acid catalysis by the hepatitis delta virus ribozyme

    Subha R Das & Joseph A Piccirilli

    doi:10.1038/nchembio703

    Nature Chemical Biology 1; 45 - 52 (2005)

    Published online: 03 May 2005

    Abstract | Full Text | PDF (443K)

  • Article

    A molecular basis for NO selectivity in soluble guanylate cyclase

    Elizabeth M Boon, Shirley H Huang & Michael A Marletta

    doi:10.1038/nchembio704

    Nature Chemical Biology 1; 53 - 59 (2005)

    Published online: 24 May 2005

    Abstract | Full Text | PDF (399K)

  • Letter

    Molecular basis of inverse agonism in a G protein–coupled receptor

    Jean-Pierre Vilardaga, Ralf Steinmeyer, Greg S Harms & Martin J Lohse

    doi:10.1038/nchembio705

    Nature Chemical Biology 1; 25 - 28 (2005)

    Published online: 24 May 2005

    Abstract | Full Text | PDF (209K)

  • Letter

    Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis

    Julian A Ferreras, Jae-Sang Ryu, Federico Di Lello, Derek S Tan & Luis E N Quadri

    doi:10.1038/nchembio706

    Nature Chemical Biology 1; 29 - 32 (2005)

    Published online: 24 May 2005

    Abstract | Full Text | PDF (198K)

  • Letter

    Activity-based probes that target diverse cysteine protease families

    Daisuke Kato, Kelly M Boatright, Alicia B Berger, Tamim Nazif, Galia Blum, Ciara Ryan, Kareem A H Chehade, Guy S Salvesen & Matthew Bogyo

    doi:10.1038/nchembio707

    Nature Chemical Biology 1; 33 - 38 (2005)

    Published online: 24 May 2005

    Abstract | Full Text | PDF (344K)

  • Letter

    Small-molecule ligand induces nucleotide flipping in (CAG)n trinucleotide repeats

    Kazuhiko Nakatani, Shinya Hagihara, Yuki Goto, Akio Kobori, Masaki Hagihara, Gosuke Hayashi, Motoki Kyo, Makoto Nomura, Masaki Mishima & Chojiro Kojima

    doi:10.1038/nchembio708

    Nature Chemical Biology 1; 39 - 43 (2005)

    Published online: 24 May 2005

    Abstract | Full Text | PDF (499K)

  • Brief Communication

    Structure of the Bacillus subtilis quorum-sensing peptide pheromone ComX

    Masahiro Okada, Isao Sato, Soo Jeong Cho, Hidehisa Iwata, Toshihiko Nishio, David Dubnau & Youji Sakagami

    doi:10.1038/nchembio709

    Nature Chemical Biology 1; 23 - 24 (2005)

    Published online: 24 May 2005

    Abstract | Full Text | PDF (120K)

  • Article

    A second-site suppressor strategy for chemical genetic analysis of diverse protein kinases

    Chao Zhang, Denise M Kenski, Jennifer L Paulson, Arale Bonshtien, Guido Sessa, Janet V Cross, Dennis J Templeton & Kevan M Shokat

    doi:10.1038/nmeth764

    Nature Methods 2; 435 - 441 (2005)

    Published online: 20 May 2005

    Abstract | Full Text | PDF (399K)

  • Protocol

    Photo-cross-linking interacting proteins with a genetically encoded benzophenone

    Ian S Farrell, Rebecca Toroney, Jennifer L Hazen, Ryan A Mehl & Jason W Chin

    doi:10.1038/nmeth0505-377

    Nature Methods 2; 377 - 384 (2005)

    Full Text | PDF (250K)

  • Article

    Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib

    Celia R Berkers, Martijn Verdoes, Eben Lichtman, Edda Fiebiger, Benedikt M Kessler, Kenneth C Anderson, Hidde L Ploegh, Huib Ovaa & Paul J Galardy

    doi:10.1038/nmeth759

    Nature Methods 2; 357 - 362 (2005)

    Published online: 21 April 2005

    Abstract | Full Text | PDF (285K)

  • Article

    A multiplexed homogeneous fluorescence-based assay for protein kinase activity in cell lysates

    Melissa D Shults, Kevin A Janes, Douglas A Lauffenburger & Barbara Imperiali

    doi:10.1038/nmeth747

    Nature Methods 2; 277 - 284 (2005)

    Published online: 23 March 2005

    Abstract | Full Text | PDF (382K)

  • Brief Communication

    In vivo protein labeling with trimethoprim conjugates: a flexible chemical tag

    Lawrence W Miller, Yunfei Cai, Michael P Sheetz & Virginia W Cornish

    doi:10.1038/nmeth749

    Nature Methods 2; 255 - 257 (2005)

    Published online: 23 March 2005

    Abstract | Full Text | PDF (265K)

  • Article

    Photo-leucine and photo-methionine allow identification of protein-protein interactions in living cells

    Monika Suchanek, Anna Radzikowska & Christoph Thiele

    doi:10.1038/nmeth752

    Nature Methods 2; 261 - 268 (2005)

    Published online: 23 March 2005

    Abstract | Full Text | PDF (247K)

  • Article

    Protein photo-cross-linking in mammalian cells by site-specific incorporation of a photoreactive amino acid

    Nobumasa Hino, Yuko Okazaki, Takatsugu Kobayashi, Akiko Hayashi, Kensaku Sakamoto & Shigeyuki Yokoyama

    doi:10.1038/nmeth739

    Nature Methods 2; 201 - 206 (2005)

    Published online: 17 February 2005

    Abstract | Full Text | PDF (358K)

  • Letter

    Chemical structure and biological activity of the Caenorhabditis elegans dauer-inducing pheromone

    Pan-Young Jeong, Mankil Jung, Yong-Hyeon Yim, Heekyeong Kim, Moonsoo Park, Eunmi Hong, Weontae Lee, Young Hwan Kim, Kun Kim & Young-Ki Paik

    doi:10.1038/nature03201

    Nature 433; 541 - 545 (2005)

    Abstract | Full Text | PDF (288K)

  • Article

    Site-specific labeling of cell surface proteins with biophysical probes using biotin ligase

    Irwin Chen, Mark Howarth, Weiying Lin & Alice Y Ting

    doi:10.1038/nmeth735

    Nature Methods 2; 99 - 104 (2005)

    Published online: 21 January 2005

    Abstract | Full Text | PDF (254K)


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