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Biochemistry
Letter
Structural basis of inter-protein electron transfer for nitrite reduction in denitrification
Masaki Nojiri, Hiroyasu Koteishi, Takuya Nakagami, Kazuo Kobayashi, Tsuyoshi Inoue, Kazuya Yamaguchi & Shinnichiro Suzuki
doi:10.1038/nature08507
Nature 462; 117 - 120 (2009)
Letter
Rationally tuning the reduction potential of a single cupredoxin beyond the natural range
Nicholas M. Marshall, Dewain K. Garner, Tiffany D. Wilson, Yi-Gui Gao, Howard Robinson, Mark J. Nilges & Yi Lu
doi:10.1038/nature08551
Nature 462; 113 - 116 (2009)
Article
Microdroplet-based PCR enrichment for large-scale targeted sequencing
Ryan Tewhey, Jason B Warner, Masakazu Nakano, Brian Libby, Martina Medkova, Patricia H David, Steve K Kotsopoulos, Michael L Samuels, J Brian Hutchison, Jonathan W Larson, Eric J Topol, Michael P Weiner, Olivier Harismendy, Jeff Olson, Darren R Link & Kelly A Frazer
doi:10.1038/nbt.1583
Nature Biotechnology 27; 1025 - 1031 (2009)
Published online: 01 November 2009
Article
In silico design of tubulin-targeted antimitotic peptides
Stefano Pieraccini, Giorgio Saladino, Graziella Cappelletti, Daniele Cartelli, Pierangelo Francescato, Giovanna Speranza, Paolo Manitto & Maurizio Sironi
doi:10.1038/nchem.401
Nature Chemistry 1; 642 - 648 (2009)
Published online: 23 October 2009
Article
A ruthenium(II) polypyridyl complex for direct imaging of DNA structure in living cells
Martin R. Gill, Jorge Garcia-Lara, Simon J. Foster, Carl Smythe, Giuseppe Battaglia & Jim A. Thomas
doi:10.1038/nchem.406
Nature Chemistry 1; 662 - 667 (2009)
Published online: 18 October 2009
Brief Communication
Enrichment of glycopeptides for glycan structure and attachment site identification
Jonas Nilsson, Ulla Rüetschi, Adnan Halim, Camilla Hesse, Elisabet Carlsohn, Gunnar Brinkmalm & Göran Larson
doi:10.1038/nmeth.1392
Nature Methods 6; 809 - 811 (2009)
Published online: 18 October 2009
Review
New medicines to improve control and contribute to the eradication of malaria
Timothy N. C. Wells, Pedro L. Alonso & Winston E. Gutteridge
doi:10.1038/nrd2972
Nature Reviews Drug Discovery 8; 879 - 891 (2009)
Published online: 16 October 2009
Letter
Exploitation of binding energy for catalysis and design
Summer B. Thyme, Jordan Jarjour, Ryo Takeuchi, James J. Havranek, Justin Ashworth, Andrew M. Scharenberg, Barry L. Stoddard & David Baker
doi:10.1038/nature08508
Nature 461; 1300 - 1304 (2009)
Letter
Imaging chromophores with undetectable fluorescence by stimulated emission microscopy
Wei Min, Sijia Lu, Shasha Chong, Rahul Roy, Gary R. Holtom & X. Sunney Xie
doi:10.1038/nature08438
Nature 461; 1105 - 1109 (2009)
Letter
Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization
Jason M. Crawford, Tyler P. Korman, Jason W. Labonte, Anna L. Vagstad, Eric A. Hill, Oliver Kamari-Bidkorpeh, Shiou-Chuan Tsai & Craig A. Townsend
doi:10.1038/nature08475
Nature 461; 1139 - 1143 (2009)
Article
Inhibitors selective for mycobacterial versus human proteasomes
Gang Lin, Dongyang Li, Luiz Pedro Sorio de Carvalho, Haiteng Deng, Hui Tao, Guillaume Vogt, Kangyun Wu, Jean Schneider, Tamutenda Chidawanyika, J. David Warren, Huilin Li & Carl Nathan
doi:10.1038/nature08357
Nature 461; 621 - 626 (2009)
Published online: 16 September 2009
Letter
A proteomics approach to discovering natural products and their biosynthetic pathways
Stefanie B Bumpus, Bradley S Evans, Paul M Thomas, Ioanna Ntai & Neil L Kelleher
doi:10.1038/nbt.1565
Nature Biotechnology 27; 951 - 956 (2009)
Published online: 20 September 2009
Article
Sensitive multiplexed analysis of kinase activities and activity-based kinase identification
Kazuishi Kubota, Rana Anjum, Yonghao Yu, Ryan C Kunz, Jannik N Andersen, Manfred Kraus, Heike Keilhack, Kumiko Nagashima, Stefan Krauss, Cloud Paweletz, Ronald C Hendrickson, Adam S Feldman, Chin-Lee Wu, John Rush, Judit Villén & Steven P Gygi
doi:10.1038/nbt.1566
Nature Biotechnology 27; 933 - 940 (2009)
Published online: 04 October 2009
Letter
Automated design of synthetic ribosome binding sites to control protein expression
Howard M Salis, Ethan A Mirsky & Christopher A Voigt
doi:10.1038/nbt.1568
Nature Biotechnology 27; 946 - 950 (2009)
Published online: 04 October 2009
Letter
Induction of protein-protein interactions in live cells using light
Masayuki Yazawa, Amir M Sadaghiani, Brian Hsueh & Ricardo E Dolmetsch
doi:10.1038/nbt.1569
Nature Biotechnology 27; 941 - 945 (2009)
Published online: 04 October 2009
Spotted vesicles, striped micelles and Janus assemblies induced by ligand binding
David A. Christian, Aiwei Tian, Wouter G. Ellenbroek, Ilya Levental, Karthikan Rajagopal, Paul A. Janmey, Andrea J. Liu, Tobias Baumgart & Dennis E. Discher
doi:10.1038/nmat2512
Nature Materials 8; 843 - 849 (2009)
Published online: 06 September 2009
Brief Communication
Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis
Jan L Vinkenborg, Tamara J Nicolson, Elisa A Bellomo, Melissa S Koay, Guy A Rutter & Maarten Merkx
doi:10.1038/nmeth.1368
Nature Methods 6; 737 - 740 (2009)
Published online: 30 August 2009
Brief Communication
Proteomics strategy for quantitative protein interaction profiling in cell extracts
Kirti Sharma, Christoph Weber, Michaela Bairlein, Zoltán Greff, György Kéri, Jürgen Cox, Jesper V Olsen & Henrik Daub
doi:10.1038/nmeth.1373
Nature Methods 6; 741 - 744 (2009)
Published online: 13 September 2009
Letter
Molecular implementation of simple logic programs
Tom Ran, Shai Kaplan & Ehud Shapiro
doi:10.1038/nnano.2009.203
Nature Nanotechnology 4; 642 - 648 (2009)
Published online: 02 August 2009
Protocol
Isotope labeling methods for studies of excited protein states by relaxation dispersion NMR spectroscopy
Patrik Lundström, Pramodh Vallurupalli, D Flemming Hansen & Lewis E Kay
doi:10.1038/nprot.2009.118
Nature Protocols 4; 1641 - 1648 (2009)
Published online: 22 October 2009
Letter
Single-molecule sequencing of an individual human genome
Dmitry Pushkarev, Norma F Neff & Stephen R Quake
doi:10.1038/nbt.1561
Nature Biotechnology 27; 847 - 850 (2009)
Published online: 10 August 2009
Letter
Organic electronics for precise delivery of neurotransmitters to modulate mammalian sensory function
Daniel T. Simon, Sindhulakshmi Kurup, Karin C. Larsson, Ryusuke Hori, Klas Tybrandt, Michel Goiny, Edwin W. H. Jager, Magnus Berggren, Barbara Canlon & Agneta Richter-Dahlfors
doi:10.1038/nmat2494
Nature Materials 8; 742 - 746 (2009)
Published online: 05 July 2009
Letter
Mechanotransductive surfaces for reversible biocatalysis activation
Damien Mertz, Cédric Vogt, Joseph Hemmerlé, Jérôme Mutterer, Vincent Ball, Jean-Claude Voegel, Pierre Schaaf & Philippe Lavalle
doi:10.1038/nmat2504
Nature Materials 8; 731 - 735 (2009)
Published online: 09 August 2009
Letter
A dual-emissive-materials design concept enables tumour hypoxia imaging
Guoqing Zhang, Gregory M. Palmer, Mark W. Dewhirst & Cassandra L. Fraser
doi:10.1038/nmat2509
Nature Materials 8; 747 - 751 (2009)
Published online: 09 August 2009
Letter
Nanolitre liquid patterning in aqueous environments for spatially defined reagent delivery to mammalian cells
H. Tavana, A. Jovic, B. Mosadegh, Q. Y. Lee, X. Liu, K. E. Luker, G. D. Luker, S. J. Weiss & S. Takayama
doi:10.1038/nmat2515
Nature Materials 8; 736 - 741 (2009)
Published online: 16 August 2009
Time-resolved RNA SHAPE chemistry: quantitative RNA structure analysis in one-second snapshots and at single-nucleotide resolution
Stefanie A Mortimer & Kevin M Weeks
doi:10.1038/nprot.2009.126
Nature Protocols 4; 1413 - 1421 (2009)
Published online: 10 September 2009
Review
Factors underlying sensitivity of cancers to small-molecule kinase inhibitors
Pasi A. Jänne, Nathanael Gray & Jeff Settleman
doi:10.1038/nrd2871
Nature Reviews Drug Discovery 8; 709 - 723 (2009)
Published online: 24 July 2009
Review Article
Molybdenum cofactors, enzymes and pathways
Günter Schwarz, Ralf R. Mendel & Markus W. Ribbe
doi:10.1038/nature08302
Nature 460; 839 - 847 (2009)
Published online: 12 August 2009
Article
Synthetic protein scaffolds provide modular control over metabolic flux
John E Dueber, Gabriel C Wu, G Reza Malmirchegini, Tae Seok Moon, Christopher J Petzold, Adeeti V Ullal, Kristala L J Prather & Jay D Keasling
doi:10.1038/nbt.1557
Nature Biotechnology 27; 753 - 759 (2009)
Published online: 02 August 2009
Letter
Sequential click reactions for synthesizing and patterning three-dimensional cell microenvironments
Cole A. DeForest, Brian D. Polizzotti & Kristi S. Anseth
doi:10.1038/nmat2473
Nature Materials 8; 659 - 664 (2009)
Published online: 21 June 2009
Brief Communication
Mass spectrometry of membrane transporters reveals subunit stoichiometry and interactions
Nelson P Barrera, Shoshanna C Isaacson, Min Zhou, Vassiliy N Bavro, Alex Welch, Theresia A Schaedler, Markus A Seeger, Ricardo Núñez Miguel, Vladimir M Korkhov, Hendrik W van Veen, Henrietta Venter, Adrian R Walmsley, Christopher G Tate & Carol V Robinson
doi:10.1038/nmeth.1347
Nature Methods 6; 585 - 587 (2009)
Published online: 05 July 2009
Brief Communication
Dereplication and de novo sequencing of nonribosomal peptides
Julio Ng, Nuno Bandeira, Wei-Ting Liu, Majid Ghassemian, Thomas L Simmons, William H Gerwick, Roger Linington, Pieter C Dorrestein & Pavel A Pevzner
doi:10.1038/nmeth.1350
Nature Methods 6; 596 - 599 (2009)
Published online: 13 July 2009
Letter
Partial sequencing of a single DNA molecule with a scanning tunnelling microscope
Hiroyuki Tanaka & Tomoji Kawai
doi:10.1038/nnano.2009.155
Nature Nanotechnology 4; 518 - 522 (2009)
Published online: 05 July 2009
Protocol
Measurement of cytochrome P450 and NADPH–cytochrome P450 reductase
F Peter Guengerich, Martha V Martin, Christal D Sohl & Qian Cheng
doi:10.1038/nprot.2009.121
Nature Protocols 4; 1245 - 1251 (2009)
Published online: 06 August 2009
Protocol
Chromatographic assays of drug oxidation by human cytochrome P450 3A4
Christal D Sohl, Qian Cheng & F Peter Guengerich
doi:10.1038/nprot.2009.122
Nature Protocols 4; 1252 - 1257 (2009)
Published online: 06 August 2009
Protocol
High-throughput fluorescence assay of cytochrome P450 3A4
Qian Cheng, Christal D Sohl & F Peter Guengerich
doi:10.1038/nprot.2009.123
Nature Protocols 4; 1258 - 1261 (2009)
Published online: 06 August 2009
Review
From carbohydrate leads to glycomimetic drugs
Beat Ernst & John L. Magnani
doi:10.1038/nrd2852
Nature Reviews Drug Discovery 8; 661 - 677 (2009)
Published online: 24 July 2009
Article
Synergistic drug combinations tend to improve therapeutically relevant selectivity
Joseph Lehár, Andrew S Krueger, William Avery, Adrian M Heilbut, Lisa M Johansen, E Roydon Price, Richard J Rickles, Glenn F Short III, Jane E Staunton, Xiaowei Jin, Margaret S Lee, Grant R Zimmermann & Alexis A Borisy
doi:10.1038/nbt.1549
Nature Biotechnology 27; 659 - 666 (2009)
Published online: 05 July 2009
Primary research
Specific fluorogenic probes for ozone in biological and atmospheric samples
Amanda L. Garner, Claudette M. St Croix, Bruce R. Pitt, George D. Leikauf, Shin Ando & Kazunori Koide
doi:10.1038/nchem.240
Nature Chemistry 1; 316 - 321 (2009)
Published online: 31 May 2009
Article
Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease
Summer L. Bernstein, Nicholas F. Dupuis, Noel D. Lazo, Thomas Wyttenbach, Margaret M. Condron, Gal Bitan, David B. Teplow, Joan-Emma Shea, Brandon T. Ruotolo, Carol V. Robinson & Michael T. Bowers
doi:10.1038/nchem.247
Nature Chemistry 1; 326 - 331 (2009)
Published online: 14 June 2009
Review
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel, Lutz Mädler, Darrell Velegol, Tian Xia, Eric M. V. Hoek, Ponisseril Somasundaran, Fred Klaessig, Vince Castranova & Mike Thompson
doi:10.1038/nmat2442
Nature Materials 8; 543 - 557 (2009)
Published online: 14 June 2009
Letter
Switchable self-protected attractions in DNA-functionalized colloids
Mirjam E. Leunissen, Rémi Dreyfus, Fook Chiong Cheong, David G. Grier, Roujie Sha, Nadrian C. Seeman & Paul M. Chaikin
doi:10.1038/nmat2471
Nature Materials 8; 590 - 595 (2009)
Published online: 14 June 2009
Letter
Rational design and application of responsive
-helical peptide hydrogelsEleanor F. Banwell, Edgardo S. Abelardo, Dave J. Adams, Martin A. Birchall, Adam Corrigan, Athene M. Donald, Mark Kirkland, Louise C. Serpell, Michael F. Butler & Derek N. Woolfson
doi:10.1038/nmat2479
Nature Materials 8; 596 - 600 (2009)
Primary research
Reaching the protein folding speed limit with large, sub-microsecond pressure jumps
Charles Dumont, Tryggvi Emilsson & Martin Gruebele
doi:10.1038/nmeth.1336
Nature Methods 6; 515 - 519 (2009)
Published online: 31 May 2009
Primary research
Protein interaction platforms: visualization of interacting proteins in yeast
Alexa M Schmitz, Monica F Morrison, Akochi O Agunwamba, Max L Nibert & Cammie F Lesser
doi:10.1038/nmeth.1337
Nature Methods 6; 500 - 502 (2009)
Published online: 31 May 2009
Brief Communication
In vivo fluorescence imaging with high-resolution microlenses
Robert P J Barretto, Bernhard Messerschmidt & Mark J Schnitzer
doi:10.1038/nmeth.1339
Nature Methods 6; 511 - 512 (2009)
Published online: 14 June 2009
Primary research
Doxycycline-dependent photoactivated gene expression in eukaryotic systems
Sidney B Cambridge, Daniel Geissler, Federico Calegari, Konstantinos Anastassiadis, Mazahir T Hasan, A Francis Stewart, Wieland B Huttner, Volker Hagen & Tobias Bonhoeffer
doi:10.1038/nmeth.1340
Nature Methods 6; 527 - 531 (2009)
Published online: 07 June 2009
Article
Mapping the structure and conformational movements of proteins with transition metal ion FRET
Justin W Taraska, Michael C Puljung, Nelson B Olivier, Galen E Flynn & William N Zagotta
doi:10.1038/nmeth.1341
Nature Methods 6; 532 - 537 (2009)
Published online: 14 June 2009
Article
Towards single-molecule nanomechanical mass spectrometry
A. K. Naik, M. S. Hanay, W. K. Hiebert, X. L. Feng & M. L. Roukes
doi:10.1038/nnano.2009.152
Nature Nanotechnology 4; 445 - 450 (2009)
Published online: 21 June 2009
Protocol
Purification of recombinant high molecular weight two-partner secretion proteins from Escherichia coli
James M Fleckenstein & Koushik Roy
doi:10.1038/nprot.2009.87
Nature Protocols 4; 1083 - 1092 (2009)
Published online: 02 July 2009
Protocol
Gel-based mass spectrometric analysis of a strongly hydrophobic GABAA-receptor subunit containing four transmembrane domains
Sung-Ung Kang, Karoline Fuchs, Werner Sieghart, Arnold Pollak, Edina Csaszar & Gert Lubec
doi:10.1038/nprot.2009.92
Nature Protocols 4; 1093 - 1102 (2009)
Published online: 02 July 2009
Reviews
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
Dunyaporn Trachootham, Jerome Alexandre & Peng Huang
doi:10.1038/nrd2803
Nature Reviews Drug Discovery 8; 579 - 591 (2009)
Published online: 29 May 2009
Letter
Structure and mechanism of a bacterial light-regulated cyclic nucleotide phosphodiesterase
Thomas R. M. Barends, Elisabeth Hartmann, Julia J. Griese, Thorsten Beitlich, Natalia V. Kirienko, Dmitri A. Ryjenkov, Jochen Reinstein, Robert L. Shoeman, Mark Gomelsky & Ilme Schlichting
doi:10.1038/nature07966
Nature 459; 1015 - 1018 (2009)
Letter
An unusual carbon–carbon bond cleavage reaction during phosphinothricin biosynthesis
Robert M. Cicchillo, Houjin Zhang, Joshua A. V. Blodgett, John T. Whitteck, Gongyong Li, Satish K. Nair, Wilfred A. van der Donk & William W. Metcalf
doi:10.1038/nature07972
Nature 459; 871 - 874 (2009)
Primary research
Metamorphic enzyme assembly in polyketide diversification
Liangcai Gu, Bo Wang, Amol Kulkarni, Todd W. Geders, Rashel V. Grindberg, Lena Gerwick, Kristina Håkansson, Peter Wipf, Janet L. Smith, William H. Gerwick & David H. Sherman
doi:10.1038/nature07870
Nature 459; 731 - 735 (2009)
Primary research
Chaperonin overexpression promotes genetic variation and enzyme evolution
Nobuhiko Tokuriki & Dan S. Tawfik
doi:10.1038/nature08009
Nature 459; 668 - 673 (2009)
Brief Communication
Proteomic analysis of S-nitrosylation and denitrosylation by resin-assisted capture
Michael T Forrester, J Will Thompson, Matthew W Foster, Leonardo Nogueira, M Arthur Moseley & Jonathan S Stamler
doi:10.1038/nbt.1545
Nature Biotechnology 27; 557 - 559 (2009)
Published online: 31 May 2009
Article
Force-activated reactivity switch in a bimolecular chemical reaction
Sergi Garcia-Manyes, Jian Liang, Robert Szoszkiewicz, Tzu-Ling Kuo & Julio M. Fernández
doi:10.1038/nchem.207
Nature Chemistry 1; 236 - 242 (2009)
Published online: 10 May 2009
Article
Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA
Kim A. Woodrow, Yen Cu, Carmen J. Booth, Jennifer K. Saucier-Sawyer, Monica J. Wood & W. Mark Saltzman
doi:10.1038/nmat2444
Nature Materials 8; 526 - 533 (2009)
Published online: 03 May 2009
Protocol
Photocrosslinking of glycoconjugates using metabolically incorporated diazirine-containing sugars
Michelle R Bond, Haochi Zhang, Peter D Vu & Jennifer J Kohler
doi:10.1038/nprot.2009.85
Nature Protocols 4; 1044 - 1063 (2009)
Published online: 18 June 2009
Primary research
The origin of the electrostatic perturbation in acetoacetate decarboxylase
Meng-Chiao Ho, Jean-François Ménétret, Hiro Tsuruta & Karen N. Allen
doi:10.1038/nature07938
Nature 459; 393 - 397 (2009)
Primary research
Discovery of dual function acridones as a new antimalarial chemotype
Jane X. Kelly, Martin J. Smilkstein, Reto Brun, Sergio Wittlin, Roland A. Cooper, Kristin D. Lane, Aaron Janowsky, Robert A. Johnson, Rozalia A. Dodean, Rolf Winter, David J. Hinrichs & Michael K. Riscoe
doi:10.1038/nature07937
Nature 459; 270 - 273 (2009)
Published online: 08 April 2009
Article
Direct measurement of the ionization state of an essential guanine in the hairpin ribozyme
Lu Liu, Joseph W Cottrell, Lincoln G Scott & Martha J Fedor
doi:10.1038/nchembio.156
Nature chemical biology 5; 351 - 357 (2009)
Published online: 29 March 2009
Article
A cell-free protein-producing gel
Nokyoung Park, Soong Ho Um, Hisakage Funabashi, Jianfeng Xu & Dan Luo
doi:10.1038/nmat2419
Nature Materials 8; 432 - 437 (2009)
Published online: 29 March 2009
Brief Communication
Single molecule–sensitive probes for imaging RNA in live cells
Philip J Santangelo, Aaron W Lifland, Paul Curt, Yukio Sasaki, Gary J Bassell, Michael E Lindquist & James E Crowe, Jr
doi:10.1038/nmeth.1316
Nature Methods 6; 347 - 349 (2009)
Published online: 06 April 2009
Brief Communication
An ultramarine fluorescent protein with increased photostability and pH insensitivity
Wataru Tomosugi, Tomoki Matsuda, Tomomi Tani, Tomomi Nemoto, Ippei Kotera, Kenta Saito, Kazuki Horikawa & Takeharu Nagai
doi:10.1038/nmeth.1317
Nature Methods 6; 351 - 353 (2009)
Published online: 06 April 2009
Brief Communication
Enzymatic assembly of DNA molecules up to several hundred kilobases
Daniel G Gibson, Lei Young, Ray-Yuan Chuang, J Craig Venter, Clyde A Hutchison, III & Hamilton O Smith
doi:10.1038/nmeth.1318
Nature Methods 6; 343 - 345 (2009)
Published online: 12 April 2009
Brief Communication
Photoconversion in orange and red fluorescent proteins
Gert-Jan Kremers, Kristin L Hazelwood, Christopher S Murphy, Michael W Davidson & David W Piston
doi:10.1038/nmeth.1319
Nature Methods 6; 355 - 358 (2009)
Published online: 12 April 2009
Article
Combined atomic force microscopy and side-view optical imaging for mechanical studies of cells
Ovijit Chaudhuri, Sapun H Parekh, Wilbur A Lam & Daniel A Fletcher
doi:10.1038/nmeth.1320
Nature Methods 6; 383 - 387 (2009)
Published online: 12 April 2009
Article
A DNA nanomachine that maps spatial and temporal pH changes inside living cells
Souvik Modi, Swetha M. G., Debanjan Goswami, Gagan D. Gupta, Satyajit Mayor & Yamuna Krishnan
doi:10.1038/nnano.2009.83
Nature Nanotechnology 4; 325 - 330 (2009)
Published online: 06 April 2009
Article
Design of protein-interaction specificity gives selective bZIP-binding peptides
Gevorg Grigoryan, Aaron W. Reinke & Amy E. Keating
doi:10.1038/nature07885
Nature 458; 859 - 864 (2009)
Letter
An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene
Eric M. Koehn, Todd Fleischmann, John A. Conrad, Bruce A. Palfey, Scott A. Lesley, Irimpan I. Mathews & Amnon Kohen
doi:10.1038/nature07973
Nature 458; 919 - 923 (2009)
Article
Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins
Bernd Wollscheid, Damaris Bausch-Fluck, Christine Henderson, Robert O'Brien, Miriam Bibel, Ralph Schiess, Ruedi Aebersold & Julian D Watts
doi:10.1038/nbt.1532
Nature Biotechnology 27; 378 - 386 (2009)
Published online: 06 April 2009
Article
A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds
Cheuk Hei Ho, Leslie Magtanong, Sarah L Barker, David Gresham, Shinichi Nishimura, Paramasivam Natarajan, Judice L Y Koh, Justin Porter, Christopher A Gray, Raymond J Andersen, Guri Giaever, Corey Nislow, Brenda Andrews, David Botstein, Todd R Graham, Minoru Yoshida & Charles Boone
doi:10.1038/nbt.1534
Nature Biotechnology 27; 369 - 377 (2009)
Published online: 06 April 2009
Article
Halogen bonds as orthogonal molecular interactions to hydrogen bonds
Andrea Regier Voth, Patricia Khuu, Keita Oishi & P. Shing Ho
doi:10.1038/nchem.112
Nature Chemistry 1; 74 - 79 (2009)
Published online: 19 March 2009
Brief Communication
SUnSET, a nonradioactive method to monitor protein synthesis
Enrico K Schmidt, Giovanna Clavarino, Maurizio Ceppi & Philippe Pierre
doi:10.1038/nmeth.1314
Nature Methods 6; 275 - 277 (2009)
Published online: 22 March 2009
Letter
Enzyme cascades activated on topologically programmed DNA scaffolds
Ofer I. Wilner, Yossi Weizmann, Ron Gill, Oleg Lioubashevski, Ronit Freeman & Itamar Willner
doi:10.1038/nnano.2009.50
Nature Nanotechnology 4; 249 - 254 (2009)
Published online: 29 March 2009
Protocol
A general protocol for the crystallization of membrane proteins for X-ray structural investigation
Zachary E R Newby, Joseph D O'Connell, III, Franz Gruswitz, Franklin A Hays, William E C Harries, Ian M Harwood, Joseph D Ho, John K Lee, David F Savage, Larry J W Miercke & Robert M Stroud
doi:10.1038/nprot.2009.27
Nature Protocols 4; 619 - 637 (2009)
Published online: 09 April 2009
Protocol
An efficient platform for screening expression and crystallization of glycoproteins produced in human cells
Jeffrey E Lee, Marnie L Fusco & Erica Ollmann Saphire
doi:10.1038/nprot.2009.29
Nature Protocols 4; 592 - 604 (2009)
Published online: 02 April 2009
Protocol
Crystallizing membrane proteins using lipidic mesophases
Martin Caffrey & Vadim Cherezov
doi:10.1038/nprot.2009.31
Nature Protocols 4; 706 - 731 (2009)
Published online: 23 April 2009
Protocol
Monitoring detergent-mediated solubilization and reconstitution of lipid membranes by isothermal titration calorimetry
Heiko Heerklotz, Alekos D Tsamaloukas & Sandro Keller
doi:10.1038/nprot.2009.35
Nature Protocols 4; 686 - 697 (2009)
Published online: 16 April 2009
Review
Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules
David Marsolais & Hugh Rosen
doi:10.1038/nrd2356
Nature Reviews Drug Discovery 8; 297 - 307 (2009)
Published online: 20 March 2009
Review
Capturing adenylyl cyclases as potential drug targets
Sandra Pierre, Thomas Eschenhagen, Gerd Geisslinger & Klaus Scholich
doi:10.1038/nrd2827
Nature Reviews Drug Discovery 8; 321 - 335 (2009)
Article
Design and engineering of an O2 transport protein
Ronald L. Koder, J. L. Ross Anderson, Lee A. Solomon, Konda S. Reddy, Christopher C. Moser & P. Leslie Dutton
doi:10.1038/nature07841
Nature 458; 305 - 309 (2009)
Letter
Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens
Sophie Brinster, Gilles Lamberet, Bart Staels, Patrick Trieu-Cuot, Alexandra Gruss & Claire Poyart
doi:10.1038/nature07772
Nature 458; 83 - 86 (2009)
Letter
Protein structure determination in living cells by in-cell NMR spectroscopy
Daisuke Sakakibara, Atsuko Sasaki, Teppei Ikeya, Junpei Hamatsu, Tomomi Hanashima, Masaki Mishima, Masatoshi Yoshimasu, Nobuhiro Hayashi, Tsutomu Mikawa, Markus Wälchli, Brian O. Smith, Masahiro Shirakawa, Peter Güntert & Yutaka Ito
doi:10.1038/nature07814
Nature 458; 102 - 105 (2009)
Letter
High-resolution multi-dimensional NMR spectroscopy of proteins in human cells
Kohsuke Inomata, Ayako Ohno, Hidehito Tochio, Shin Isogai, Takeshi Tenno, Ikuhiko Nakase, Toshihide Takeuchi, Shiroh Futaki, Yutaka Ito, Hidekazu Hiroaki & Masahiro Shirakawa
doi:10.1038/nature07839
Nature 458; 106 - 109 (2009)
Brief Communication
Nanomole-scale protein solid-state NMR by breaking intrinsic 1H T1 boundaries
Nalinda P Wickramasinghe, Sudhakar Parthasarathy, Christopher R Jones, Chhavi Bhardwaj, Fei Long, Mrignayani Kotecha, Shahila Mehboob, Leslie W-M Fung, Jaan Past, Ago Samoson & Yoshitaka Ishii
doi:10.1038/nmeth.1300
Nature Methods 6; 215 - 218 (2009)
Published online: 08 February 2009
Brief Communication
Quantitative interaction proteomics using mass spectrometry
Alexander Wepf, Timo Glatter, Alexander Schmidt, Ruedi Aebersold & Matthias Gstaiger
doi:10.1038/nmeth.1302
Nature Methods 6; 203 - 205 (2009)
Published online: 08 February 2009
Letter
A smart dust biosensor powered by kinesin motors
Thorsten Fischer, Ashutosh Agarwal & Henry Hess
doi:10.1038/nnano.2008.393
Nature Nanotechnology 4; 162 - 166 (2009)
Published online: 18 January 2009
Review
Molecular targets for cancer chemoprevention
William N. William, Jr, John V. Heymach, Edward S. Kim & Scott M. Lippman
doi:10.1038/nrd2663
Nature Reviews Drug Discovery 8; 213 - 225 (2009)
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Glycosylation as a strategy to improve antibody-based therapeutics
Roy Jefferis
doi:10.1038/nrd2804
Nature Reviews Drug Discovery 8; 226 - 234 (2009)
Review
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Protein promiscuity and its implications for biotechnology
Irene Nobeli, Angelo D Favia & Janet M Thornton
doi:10.1038/nbt1519
Nature Biotechnology 27; 157 - 167 (2009)
Published online: 09 February 2009
Article
A genetically encoded fluorescent reporter of ATP:ADP ratio
Jim Berg, Yin Pun Hung & Gary Yellen
doi:10.1038/nmeth.1288
Nature Methods 6; 161 - 166 (2009)
Published online: 04 January 2009
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Microfluidic control of cell pairing and fusion
Alison M Skelley, Oktay Kirak, Heikyung Suh, Rudolf Jaenisch & Joel Voldman
doi:10.1038/nmeth.1290
Nature Methods 6; 147 - 152 (2009)
Published online: 04 January 2009
Brief Communication
Large-scale profiling of protein palmitoylation in mammalian cells
Brent R Martin & Benjamin F Cravatt
doi:10.1038/nmeth.1293
Nature Methods 6; 135 - 138 (2009)
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Brief Communication
A bright and photostable photoconvertible fluorescent protein
Sean A McKinney, Christopher S Murphy, Kristin L Hazelwood, Michael W Davidson & Loren L Looger
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Nature Methods 6; 131 - 133 (2009)
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Photoactivatable mCherry for high-resolution two-color fluorescence microscopy
Fedor V Subach, George H Patterson, Suliana Manley, Jennifer M Gillette, Jennifer Lippincott-Schwartz & Vladislav V Verkhusha
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Nature Methods 6; 153 - 159 (2009)
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Review Article
The promises and pitfalls of RNA-interference-based therapeutics
Daniela Castanotto & John J. Rossi
doi:10.1038/nature07758
Nature 457; 426 - 433 (2009)
Published online: 21 January 2009
Research Highlight
Biopolymer modelling: Through the eye of a needle
Stephen Davey
doi:10.1038/nchem.108
Nature Chemistry (2009)
Published online: 09 January 2009
Letter
Structural basis for androgen specificity and oestrogen synthesis in human aromatase
Debashis Ghosh, Jennifer Griswold, Mary Erman & Walter Pangborn
doi:10.1038/nature07614
Nature 457; 219 - 223 (2009)
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Self-assembling chimeric polypeptide–doxorubicin conjugate nanoparticles that abolish tumours after a single injection
J. Andrew MacKay, Mingnan Chen, Jonathan R. McDaniel, Wenge Liu, Andrew J. Simnick & Ashutosh Chilkoti
doi:10.1038/nmat2569
Nature Materials
Published online: 08 November 2009
Infrared laser–mediated gene induction in targeted single cells in vivo
Yasuhiro Kamei, Motoshi Suzuki, Kenjiro Watanabe, Kazuhiro Fujimori, Takashi Kawasaki, Tomonori Deguchi, Yoshihiro Yoneda, Takeshi Todo, Shin Takagi, Takashi Funatsu & Shunsuke Yuba
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Nature Methods 6
An in vitro microfluidic approach to generating protein-interaction networks
Doron Gerber, Sebastian J Maerkl & Stephen R Quake
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Nature Methods 6
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Self-assembled arrays of peptide nanotubes by vapour deposition
Lihi Adler-Abramovich, Daniel Aronov, Peter Beker, Maya Yevnin, Shiri Stempler, Ludmila Buzhansky, Gil Rosenman & Ehud Gazit
doi:10.1038/nnano.2009.298
Nature Nanotechnology
Published online: 18 October 2009
Article
Self-assembly of carbon nanotubes into two-dimensional geometries using DNA origami templates
Hareem T. Maune, Si-ping Han, Robert D. Barish, Marc Bockrath, William A. Goddard III, Paul W. K. Rothemund & Erik Winfree
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Nature Nanotechnology
Published online: 08 November 2009
