Cancer Gene Therapy

Effect of sonoporation on cationic liposome-mediated IFNβ gene therapy for metastatic hepatic tumors of murine colon cancer

S Hayashi — 2009-06-05

Effect of sonoporation on cationic liposome-mediated IFNβ gene therapy for metastatic hepatic tumors of murine colon cancer

Cancer Gene Therapy advance online publication, June 5, 2009. doi:10.1038/cgt.2008.1

Authors: S Hayashi, M Mizuno, J Yoshida & A Nakao

Deletion of the E3-6.7K/gp19K region reduces the persistence of wild-type adenovirus in a permissive tumor model in Syrian hamsters

S Bortolanza — 200-02-20

Deletion of the E3-6.7K/gp19K region reduces the persistence of wild-type adenovirus in a permissive tumor model in Syrian hamsters

Cancer Gene Therapy advance online publication, February 20, 2009. doi:10.1038/cgt.2009.12

Authors: S Bortolanza, M Bunuales, P Alzuguren, O Lamas, R Aldabe, J Prieto & R Hernandez-Alcoceba

DNAzymes to mouse β1 integrin mRNA in vivo: targeting the tumor vasculature and retarding cancer growth

J Niewiarowska — 200-02-27

DNAzymes to mouse β1 integrin mRNA in vivo: targeting the tumor vasculature and retarding cancer growth

Cancer Gene Therapy advance online publication, February 27, 2009. doi:10.1038/cgt.2009.13

Authors: J Niewiarowska, I Sacewicz, M Wiktorska, T Wysocki, O Stasikowska, M Wagrowska-Danilewicz & C S Cierniewski

Suppression of N-Ras by shRNA-expressing plasmid increases sensitivity of HepG2 cells to vincristine-induced growth inhibition

H-x Sun — 200-02-27

Suppression of N-Ras by shRNA-expressing plasmid increases sensitivity of HepG2 cells to vincristine-induced growth inhibition

Cancer Gene Therapy advance online publication, February 27, 2009. doi:10.1038/cgt.2009.14

Authors: H-x Sun, H-w He, S-h Zhang, T-g Liu, K-h Ren, Q-y He & R-g Shao

Phase II trial of Belagenpumatucel-L, a TGF-β2 antisense gene modified allogeneic tumor vaccine in advanced non small cell lung cancer (NSCLC) patients

J Nemunaitis — 2009-03-13

Phase II trial of Belagenpumatucel-L, a TGF-β2 antisense gene modified allogeneic tumor vaccine in advanced non small cell lung cancer (NSCLC) patients

Cancer Gene Therapy advance online publication, March 13, 2009. doi:10.1038/cgt.2009.15

Authors: J Nemunaitis, M Nemunaitis, N Senzer, P Snitz, C Bedell, P Kumar, B Pappen, P B Maples, D Shawler & H Fakhrai

MLH1 deficiency enhances tumor cell sensitivity to ganciclovir

J J O'Konek — 2009-03-20

MLH1 deficiency enhances tumor cell sensitivity to ganciclovir

Cancer Gene Therapy advance online publication, March 20, 2009. doi:10.1038/cgt.2009.16

Authors: J J O'Konek, P D Boucher, A A Iacco, T E Wilson & D S Shewach

Optimization of vaccine responses with an E1, E2b and E3-deleted Ad5 vector circumvents pre-existing anti-vector immunity

T Osada — 200-02-20

Optimization of vaccine responses with an E1, E2b and E3-deleted Ad5 vector circumvents pre-existing anti-vector immunity

Cancer Gene Therapy advance online publication, February 20, 2009. doi:10.1038/cgt.2009.17

Authors: T Osada, X Y Yang, Z C Hartman, O Glass, B L Hodges, D Niedzwiecki, M A Morse, H K Lyerly, A Amalfitano & T M Clay

Phase I and biodistribution study of recombinant adenovirus vector-mediated herpes simplex virus thymidine kinase gene and ganciclovir administration in patients with head and neck cancer and other malignant tumors

F Xu — 2009-04-10

Phase I and biodistribution study of recombinant adenovirus vector-mediated herpes simplex virus thymidine kinase gene and ganciclovir administration in patients with head and neck cancer and other malignant tumors

Cancer Gene Therapy advance online publication, April 10, 2009. doi:10.1038/cgt.2009.19

Authors: F Xu, S Li, X-L Li, Y Guo, B-Y Zou, R Xu, H Liao, H-Y Zhao, Y Zhang, Z-Z Guan & L Zhang

Adenovirus-based virotherapy enabled by cellular YB-1 expression in vitro and in vivo

E Rognoni — 2009-04-10

Adenovirus-based virotherapy enabled by cellular YB-1 expression in vitro and in vivo

Cancer Gene Therapy advance online publication, April 10, 2009. doi:10.1038/cgt.2009.20

Authors: E Rognoni, M Widmaier, C Haczek, K Mantwill, R Holzmüller, B Gansbacher, A Kolk, T Schuster, R M Schmid, D Saur, A Kaszubiak, H Lage & P S Holm

Cytotoxicity of adenoviruses expressing the wild-type p53 gene to esophageal carcinoma cells is linked with the CAR expression level and indirectly with the endogenous p53 status

G Ma — 2009-04-10

Cytotoxicity of adenoviruses expressing the wild-type p53 gene to esophageal carcinoma cells is linked with the CAR expression level and indirectly with the endogenous p53 status

Cancer Gene Therapy advance online publication, April 10, 2009. doi:10.1038/cgt.2009.21

Authors: G Ma, K Kawamura, Q Li, N Suzuki, M Liang, M Namba, H Shimada & M Tagawa

Combined inhibition of PAK7, MAP3K7 and CK2α kinases inhibits the growth of MiaPaCa2 pancreatic cancer cell xenografts

V Giroux — 2009-04-10

Combined inhibition of PAK7, MAP3K7 and CK2α kinases inhibits the growth of MiaPaCa2 pancreatic cancer cell xenografts

Cancer Gene Therapy advance online publication, April 10, 2009. doi:10.1038/cgt.2009.22

Authors: V Giroux, J L Iovanna, S Garcia & J-C Dagorn

CRAdRGDflt-IL24 virotherapy in combination with chemotherapy of experimental glioma

L N Kaliberova — 2009-04-10

CRAdRGDflt-IL24 virotherapy in combination with chemotherapy of experimental glioma

Cancer Gene Therapy advance online publication, April 10, 2009. doi:10.1038/cgt.2009.23

Authors: L N Kaliberova, V Krendelchtchikova, D K Harmon, C R Stockard, A S Petersen, J M Markert, G Y Gillespie, W E Grizzle, D J Buchsbaum & S A Kaliberov

Paclitaxel combined with siRNA targeting HPV16 oncogenes improves cytotoxicity for cervical carcinoma

W-l Liu — 2009-04-10

Paclitaxel combined with siRNA targeting HPV16 oncogenes improves cytotoxicity for cervical carcinoma

Cancer Gene Therapy advance online publication, April 10, 2009. doi:10.1038/cgt.2009.24

Authors: W-l Liu, N Green, L W Seymour & M Stevenson

PNAEμ can significantly reduce Burkitt's lymphoma tumor burden in a SCID mice model: cells dissemination similar to the human disease

S Matis — 2009-04-10

PNAEμ can significantly reduce Burkitt's lymphoma tumor burden in a SCID mice model: cells dissemination similar to the human disease

Cancer Gene Therapy advance online publication, April 10, 2009. doi:10.1038/cgt.2009.26

Authors: S Matis, M R Mariani, G Cutrona, M Cilli, F Piccardi, A Daga, G Damonte, E Millo, M Moroni, S Roncella, F Fedeli, L C Boffa & M Ferrarini

Adenoviral-mediated, intratumor gene transfer of interleukin 23 induces a therapeutic antitumor response

J Reay — 2009-04-24

Adenoviral-mediated, intratumor gene transfer of interleukin 23 induces a therapeutic antitumor response

Cancer Gene Therapy advance online publication, April 24, 2009. doi:10.1038/cgt.2009.27

Authors: J Reay, S-H Kim, E Lockhart, J Kolls & P D Robbins

Lentiviruses with trastuzumab bound to their envelopes can target and kill prostate cancer cells

K-x Zhang — 2009-04-17

Lentiviruses with trastuzumab bound to their envelopes can target and kill prostate cancer cells

Cancer Gene Therapy advance online publication, April 17, 2009. doi:10.1038/cgt.2009.28

Authors: K-x Zhang, M Moussavi, C Kim, E Chow, I S Chen, L Fazli, W Jia & P S Rennie

RNA interference-mediated knockdown of p21WAF1 enhances anti-tumor cell activity of oncolytic adenoviruses

M Shiina — 2009-05-01

RNA interference-mediated knockdown of p21WAF1 enhances anti-tumor cell activity of oncolytic adenoviruses

Cancer Gene Therapy advance online publication, May 1, 2009. doi:10.1038/cgt.2009.29

Authors: M Shiina, M D Lacher, C Christian & W M Korn

Novel strategies to augment genetically delivered immunotoxin molecular therapy for cancer therapy

X Liu — 2009-05-22

Novel strategies to augment genetically delivered immunotoxin molecular therapy for cancer therapy

Cancer Gene Therapy advance online publication, May 22, 2009. doi:10.1038/cgt.2009.30

Authors: X Liu, J Wu, S Zhang, C Li & Q Huang

Adenovirus delivery of human CD40 ligand gene confers direct therapeutic effects on carcinomas

L Vardouli — 2009-05-22

Adenovirus delivery of human CD40 ligand gene confers direct therapeutic effects on carcinomas

Cancer Gene Therapy advance online publication, May 22, 2009. doi:10.1038/cgt.2009.31

Authors: L Vardouli, C Lindqvist, K Vlahou, A S I Loskog & A G Eliopoulos

Combination of human tumor necrosis factor-alpha (hTNF-α) gene delivery with gemcitabine is effective in models of pancreatic cancer

S R Murugesan — 2009-05-15

Combination of human tumor necrosis factor-alpha (hTNF-α) gene delivery with gemcitabine is effective in models of pancreatic cancer

Cancer Gene Therapy advance online publication, May 15, 2009. doi:10.1038/cgt.2009.32

Authors: S R Murugesan, C R King, R Osborn, W R Fairweather, E M O'Reilly, M O Thornton & L L Wei

Conditional interleukin-12 gene therapy promotes safe and effective antitumor immunity

H Komita — 2009-05-15

Conditional interleukin-12 gene therapy promotes safe and effective antitumor immunity

Cancer Gene Therapy advance online publication, May 15, 2009. doi:10.1038/cgt.2009.33

Authors: H Komita, X Zhao, A K Katakam, P Kumar, M Kawabe, H Okada, J M Braughler & W J Storkus

Anticancer oncolytic activity of respiratory syncytial virus

I Echchgadda — 2009-05-15

Anticancer oncolytic activity of respiratory syncytial virus

Cancer Gene Therapy advance online publication, May 15, 2009. doi:10.1038/cgt.2009.34

Authors: I Echchgadda, S Kota, I DeLa Cruz, A Sabbah, T Chang, R Harnack, V Mgbemena, B Chatterjee & S Bose

WT1 gene silencing by aerosol delivery of PEI–RNAi complexes inhibits B16-F10 lung metastases growth

D E Zamora-Avila — 2009-05-22

WT1 gene silencing by aerosol delivery of PEI–RNAi complexes inhibits B16-F10 lung metastases growth

Cancer Gene Therapy advance online publication, May 22, 2009. doi:10.1038/cgt.2009.35

Authors: D E Zamora-Avila, P Zapata-Benavides, M A Franco-Molina, S Saavedra-Alonso, L M Trejo-Avila, D Reséndez-Pérez, J L Méndez-Vázquez, J Isaias-Badillo & C Rodríguez-Padilla

New pancreatic carcinoma model for studying oncolytic adenoviruses in the permissive Syrian hamster

J F Spencer — 2009-05-29

New pancreatic carcinoma model for studying oncolytic adenoviruses in the permissive Syrian hamster

Cancer Gene Therapy advance online publication, May 29, 2009. doi:10.1038/cgt.2009.36

Authors: J F Spencer, J E Sagartz, W S M Wold & K Toth

Translation of the radio- and chemo-inducible TNFerade vector to the treatment of human cancers

R R Weichselbaum — 2009-05-15

Translation of the radio- and chemo-inducible TNFerade vector to the treatment of human cancers

Cancer Gene Therapy advance online publication, May 15, 2009. doi:10.1038/cgt.2009.37

Authors: R R Weichselbaum & D Kufe

Oncolytic adenovirus expressing interleukin-18 induces significant antitumor effects against melanoma in mice through inhibition of angiogenesis

J-N Zheng — 2009-06-05

Oncolytic adenovirus expressing interleukin-18 induces significant antitumor effects against melanoma in mice through inhibition of angiogenesis

Cancer Gene Therapy advance online publication, June 5, 2009. doi:10.1038/cgt.2009.38

Authors: J-N Zheng, D-S Pei, L-J Mao, X-Y Liu, F-H Sun, B-F Zhang, Y-Q Liu, J-J Liu, W Li & D Han

Dendritic cells engineered to secrete anti-GITR antibodies are effective adjuvants to dendritic cell-based immunotherapy

D Boczkowski — 2009-06-05

Dendritic cells engineered to secrete anti-GITR antibodies are effective adjuvants to dendritic cell-based immunotherapy

Cancer Gene Therapy advance online publication, June 5, 2009. doi:10.1038/cgt.2009.39

Authors: D Boczkowski, J Lee, S Pruitt & S Nair

Dynamics of multiple myeloma tumor therapy with a recombinant measles virus

D Dingli — 2009-06-05

Dynamics of multiple myeloma tumor therapy with a recombinant measles virus

Cancer Gene Therapy advance online publication, June 5, 2009. doi:10.1038/cgt.2009.40

Authors: D Dingli, C Offord, R Myers, K-W Peng, T W Carr, K Josic, S J Russell & Z Bajzer

Enhancement of antitumor activity of gammaretrovirus carrying IL-12 gene through genetic modification of envelope targeting HER2 receptor: a promising strategy for bladder cancer therapy

Y-S Tsai — 2009-06-19

Enhancement of antitumor activity of gammaretrovirus carrying IL-12 gene through genetic modification of envelope targeting HER2 receptor: a promising strategy for bladder cancer therapy

Cancer Gene Therapy advance online publication, June 19, 2009. doi:10.1038/cgt.2009.41

Authors: Y-S Tsai, A-L Shiau, Y-F Chen, H-T Tsai, T-S Tzai & C-L Wu

Mutant mouse p53 transgene elevates the chemical induction of tumors that respond to gene silencing with siRNA

H Tanooka — 2009-06-26

Mutant mouse p53 transgene elevates the chemical induction of tumors that respond to gene silencing with siRNA

Cancer Gene Therapy advance online publication, June 26, 2009. doi:10.1038/cgt.2009.43

Authors: H Tanooka, K Tatsumi, H Tsuji, Y Noda, T Katsube, H Ishii, A Ootsuyama, F Takeshita & T Ochiya

Antitumoral efficacy of DNA nanoparticles in murine models of lung cancer and pulmonary metastasis

M Rodrigo-Garzón — 2009-07-03

Antitumoral efficacy of DNA nanoparticles in murine models of lung cancer and pulmonary metastasis

Cancer Gene Therapy advance online publication, July 3, 2009. doi:10.1038/cgt.2009.45

Authors: M Rodrigo-Garzón, P Berraondo, L Ochoa, J J Zulueta & G González-Aseguinolaza

An acute toxicology study with INGN 007, an oncolytic adenovirus vector, in mice and permissive Syrian hamsters; comparisons with wild-type Ad5 and a replication-defective adenovirus vector

D L Lichtenstein — 200-02-06

An acute toxicology study with INGN 007, an oncolytic adenovirus vector, in mice and permissive Syrian hamsters; comparisons with wild-type Ad5 and a replication-defective adenovirus vector

Cancer Gene Therapy advance online publication, February 6, 2009. doi:10.1038/cgt.2009.5

Authors: D L Lichtenstein, J F Spencer, K Doronin, D Patra, J M Meyer, E V Shashkova, M Kuppuswamy, D Dhar, M A Thomas, A E Tollefson, L A Zumstein, W S M Wold & K Toth

INGN 007, an oncolytic adenovirus vector, replicates in Syrian hamsters but not mice: comparison of biodistribution studies

B Ying — 200-02-06

INGN 007, an oncolytic adenovirus vector, replicates in Syrian hamsters but not mice: comparison of biodistribution studies

Cancer Gene Therapy advance online publication, February 6, 2009. doi:10.1038/cgt.2009.6

Authors: B Ying, K Toth, J F Spencer, J Meyer, A E Tollefson, D Patra, D Dhar, E V Shashkova, M Kuppuswamy, K Doronin, M A Thomas, L A Zumstein, W S M Wold & D L Lichtenstein

Bifidobacterium longum as a delivery system of TRAIL and endostatin cooperates with chemotherapeutic drugs to inhibit hypoxic tumor growth

B Hu — 200-02-20

Bifidobacterium longum as a delivery system of TRAIL and endostatin cooperates with chemotherapeutic drugs to inhibit hypoxic tumor growth

Cancer Gene Therapy advance online publication, February 20, 2009. doi:10.1038/cgt.2009.7

Authors: B Hu, L Kou, C Li, L-P Zhu, Y-R Fan, Z-W Wu, J-J Wang & G-X Xu

Controlling brain tumor growth by intraventricular administration of an AAV vector encoding IFN-β

D H Meijer — 200-02-06

Controlling brain tumor growth by intraventricular administration of an AAV vector encoding IFN-β

Cancer Gene Therapy advance online publication, February 6, 2009. doi:10.1038/cgt.2009.8

Authors: D H Meijer, C A Maguire, S G LeRoy & M Sena-Esteves