Cancer Gene Therapy

TABLE 1

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Adenovirus-mediated PTEN treatment combined with caffeine produces a synergistic therapeutic effect in colorectal cancer cells

Yuji Saito, Began Gopalan, Abner M Mhashilkar, Jack A Roth, Sunil Chada, Louis Zumstein and Rajagopal Ramesh

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Table 1. Therapeutic effect produced in various cell lines when treated with a combination of Ad-PTEN and caffeine is independent of PTEN and p53 status

Figure and tables index
Cell linesPTEN allelesp53 statusCell cycle arrestIsobologram
HCT116(+/+)WildWildG2 Synergistic
HCT116(-/-)WildDeletionG2 Synergistic and additive
SW480WildMutantG2 Synergistic
DLD-1WildMutantG2 Synergistic and additive
CCD-18Coa WildWildG2 Protective
DU145b WildMutantG2 Synergistic and additive
     
LnCAPb MutantWildG1 Additive

a Normal colon fibroblast cell line.

b Prostate cancer cell not sequenced for PTEN.

Figure and tables index
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