Cancer Gene Therapy

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Adenovirus-mediated PTEN treatment combined with caffeine produces a synergistic therapeutic effect in colorectal cancer cells

Yuji Saito, Began Gopalan, Abner M Mhashilkar, Jack A Roth, Sunil Chada, Louis Zumstein and Rajagopal Ramesh

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Figure 1.

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Isobologram analysis of the effects of treatment with two-agent combinations on colorectal cell lines. Cells seeded in 96-well plates were treated with various concentrations of Ad-PTEN, caffeine, Ad-PTEN, or Ad-Luc and caffeine. At 72 hours after treatment, isobolograms at IC50 levels were generated in colorectal cancer cell lines (HCT116dotp53 (+ / +), HCT116dotp53 (- / -), SW480, DLD-1) (a) and (c), and normal colorectal fibroblast cells (CCD-18Co), (b), treated with combinations of Ad-PTEN and caffeine (a) and (b), or Ad-Luc and caffeine (c).

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