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APOPTOSIS
Review: Jesenberger, V. & Jentsch, S. Deadly encounter: ubiquitin meets apoptosis. Nature Rev. Mol. Cell Biol. 3, 112-121 (2002) Research papers: Flores, E. et al. p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature 416, 560-564 (2002) D'Orazi, G. et al. Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nature Cell Biol. 4, 11-19 (2002) Hofmann, T. G. et al. Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nature Cell Biol. 4, 1-10 (2002) Raveh, T., Droguett, G., Horowitz, M. S., DePinho, R. A. & Kimchi, A. DAP kinase activates a p19ARF/p53-mediated apoptic checkpoint to suppress oncogenic transformation. Nature Cell Biol. 3, 1-7 (2001) Schwarz, A. et al. Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair. Nature Cell Biol. 4, 26-31 (2002) Timeline: Lockshin, R. A. & Zakeri, Z. Programmed cell death and apoptosis: origins of the theory. Nature Rev. Mol. Cell Biol. 2, 545-550 (2001) Highlights: · Cancer cells come to a sticky end  · The p53 mafia · A death or death situation · ASPP bites · Deadly FLAME · Death by PUMA · Dodging death at division? · Drifting downstream · Grim, reaper and the sickle of death |
