THIS MONTH IN CELL DEATH & DISEASE

Volume 5, May 2014

Special Issue on "Systems Biology approach to investigate cell death pathways in diseases"

Disturbances in cell death pathways result in pathogenesis of various disorders. Thus, too much cell death is associated with neurological and immunological diseases and too little cell death is associated with development of malignancies. There are many pathological situations when cross-talk between different cell death subroutines plays significant role and treatment of all of these disorders is based on the attempts either to suppress, or induce cell death. To understand the mechanism of complex cross-talks, especially, in multifactorial disorders, an integrated systems biology approach is essential. A unified "language" model) helps to define the proper functioning of the biological system. Systemic understanding of cell death pathways is crucial to refine the molecular diagnosis of diseases, associated with dysfunction of cell death. It is helpful in optimizing the calculation of prognostic and predictive parameters of guiding new strategies of existing treatments and identification of novel targets for therapies based on modulation of cell death pathways. This issue of Cell Death & Disease includes several reviews focusing on different angles of system biology requirement for cell death research and medical applications and will be interesting for cell biologists, bioinformaticians, and physicians.

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May 29 2014

Correspondence

CREAM: a database for chemotherapy resistance-associated miRSNP

E Dai, Y Lv, F Meng, X Yu, Y Zhang, S Wang, X Liu, D Liu, J Wang, X Li and W Jiang

Cell Death Dis 5: e1272; doi:10.1038/cddis.2014.236

Subject Category: Cancer

Original Article

Degradation of mutant p53H175 protein by Zn(II) through autophagy

A Garufi, D Pucci, V D’Orazi, M Cirone, G Bossi, M L Avantaggiati and G D’Orazi

Cell Death Dis 5: e1271; doi:10.1038/cddis.2014.217

Subject Category: Cancer

Original Article

Involvement of p38 in signal switching from autophagy to apoptosis via the PERK/eIF2α/ATF4 axis in selenite-treated NB4 cells

Q Jiang, F Li, K Shi, P Wu, J An, Y Yang and C Xu

Cell Death Dis 5: e1270; doi:10.1038/cddis.2014.200

Subject Category: Cancer

Original Article

Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment

H Matsumoto, Y Murakami, K Kataoka, H Lin, K M Connor, J W Miller, D Zhou, J Avruch and D G Vavvas

Cell Death Dis 5: e1269; doi:10.1038/cddis.2014.218

Subject Category: Neuroscience

Original Article

The cockayne syndrome B protein is essential for neuronal differentiation and neuritogenesis

F Ciaffardini, S Nicolai, M Caputo, G Canu, E Paccosi, M Costantino, M Frontini, A S Balajee and L Proietti-De-Santis

Cell Death Dis 5: e1268; doi:10.1038/cddis.2014.228

Subject Category: Neuroscience

Original Article

Macropinocytosis and TAK1 mediate anti-inflammatory to pro-inflammatory macrophage differentiation by HIV-1 Nef

M Hashimoto, H Nasser, T Chihara and S Suzu

Cell Death Dis 5: e1267; doi:10.1038/cddis.2014.233

Subject Category: Immunity

Review

Bioactive lipids and the control of Bax pro-apoptotic activity

V Mignard, L Lalier, F Paris and F M Vallette

Cell Death Dis 5: e1266; doi:10.1038/cddis.2014.226

Subject Category: Cancer

Original Article

Role of alpha-synuclein in autophagy modulation of primary human T lymphocytes

T Colasanti, M Vomero, C Alessandri, C Barbati, A Maselli, C Camperio, F Conti, A Tinari, C Carlo-Stella, L Tuosto, D Benincasa, G Valesini, W Malorni, M Pierdominici and E Ortona

Cell Death Dis 5: e1265; doi:10.1038/cddis.2014.211

Subject Category: Immunity

Original Article

Serum-dependent processing of late apoptotic cells for enhanced efferocytosis

Y Y Liang, T Arnold, A Michlmayr, D Rainprecht, B Perticevic, A Spittler and R Oehler

Cell Death Dis 5: e1264; doi:10.1038/cddis.2014.210

Subject Category: Immunity

Original Article

Elf3 drives β-catenin transactivation and associates with poor prognosis in colorectal cancer

J-L Wang, Z-F Chen, H-M Chen, M-Y Wang, X Kong, Y-C Wang, T-T Sun, J Hong, W Zou, J Xu and J-Y Fang

Cell Death Dis 5: e1263; doi:10.1038/cddis.2014.206

Subject Category: Cancer

Original Article

Receptor-interacting protein kinases modulate noise-induced sensory hair cell death

H-W Zheng, J Chen and S-H Sha

Cell Death Dis 5: e1262; doi:10.1038/cddis.2014.177

Subject Category: Neuroscience

Review

Cell-to-cell variability in cell death: can systems biology help us make sense of it all?  

X Xia, M S Owen, R E C Lee and S Gaudet

Cell Death Dis 5: e1261; doi:10.1038/cddis.2014.199

Subject Category: Cancer

Review

Systems biology approaches to develop innovative strategies for lung cancer therapy  

K Viktorsson, R Lewensohn and B Zhivotovsky

Cell Death Dis 5: e1260; doi:10.1038/cddis.2014.28

Subject Category: Cancer

Review

Systems biology of death receptor networks: live and let die  

I N Lavrik

Cell Death Dis 5: e1259; doi:10.1038/cddis.2014.160

Subject Category: Cancer

Review

From computational modelling of the intrinsic apoptosis pathway to a systems-based analysis of chemotherapy resistance: achievements, perspectives and challenges in systems medicine  

M L Würstle, E Zink, J H M Prehn and M Rehm

Cell Death Dis 5: e1258; doi:10.1038/cddis.2014.36

Subject Category: Cancer

Review

Systems biology of cisplatin resistance: past, present and future  

L Galluzzi, I Vitale, J Michels, C Brenner, G Szabadkai, A Harel-Bellan, M Castedo and G Kroemer

Cell Death Dis 5: e1257; doi:10.1038/cddis.2013.428

Subject Category: Cancer

Editorial

Systems biology: a way to make complex problems more understandable  

I N Lavrik and B Zhivotovsky

Cell Death Dis 5: e1256; doi:10.1038/cddis.2014.195

Top

May 22 2014

Original Article

Radiation induces senescence and a bystander effect through metabolic alterations

E-C Liao, Y-T Hsu, Q-Y Chuah, Y-J Lee, J-Y Hu, T-C Huang, P-M Yang and S-J Chiu

Cell Death Dis 5: e1255; doi:10.1038/cddis.2014.220

Subject Category: Cancer Metabolism

Corrigendum

HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma

M Granato, V Lacconi, M Peddis, L V Lotti, L Di Renzo, R Gonnella, R Santarelli, P Trivedi, L Frati, G D'Orazi, A Faggioni and M Cirone

Cell Death Dis 5: e1254; doi:10.1038/cddis.2014.238

Original Article

DNA replication stress in CHK1-depleted tumour cells triggers premature (S-phase) mitosis through inappropriate activation of Aurora kinase B

P Zuazua-Villar, R Rodriguez, M E Gagou, P A Eyers and M Meuth

Cell Death Dis 5: e1253; doi:10.1038/cddis.2014.231

Subject Category: Cancer

Original Article

Non-viral FoxM1 gene delivery to hepatocytes enhances liver repopulation

D Xiang, C-C Liu, M-J Wang, J-X Li, F Chen, H Yao, B Yu, L Lu, U Borjigin, Y-X Chen, L Zhong, K J Wangensteen, Z-Y He, X Wang and Y-P Hu

Cell Death Dis 5: e1252; doi:10.1038/cddis.2014.230

Subject Category: Experimental Medicine

Original Article

Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk/MAP kinase pathway mediated by cAMP/PKA signaling

D Liu, Y Huang, D Bu, A D Liu, L Holmberg, Y Jia, C Tang, J Du and H Jin

Cell Death Dis 5: e1251; doi:10.1038/cddis.2014.229

Subject Category: Experimental Medicine

Original Article

Altered expression of Alzheimer’s disease-related genes in the cerebellum of autistic patients: a model for disrupted brain connectome and therapy

F Zeidán-Chuliá, B-HN de Oliveira, A B Salmina, M F Casanova, D P Gelain, M Noda, A Verkhratsky and J CF Moreira

Cell Death Dis 5: e1250; doi:10.1038/cddis.2014.227

Subject Category: Neuroscience

Original Article

The CT20 peptide causes detachment and death of metastatic breast cancer cells by promoting mitochondrial aggregation and cytoskeletal disruption

M W Lee, R Bassiouni, N A Sparrow, A Iketani, R J Boohaker, C Moskowitz, P Vishnubhotla, A S Khaled, J Oyer, A Copik, C Fernandez-Valle, J M Perez and A R Khaled

Cell Death Dis 5: e1249; doi:10.1038/cddis.2014.225

Subject Category: Experimental Medicine

Original Article

Upregulation and nuclear translocation of testicular ghrelin protects differentiating spermatogonia from ionizing radiation injury

W Li, Y Zeng, J Zhao, C-J Zhu, W-G Hou and S Zhang

Cell Death Dis 5: e1248; doi:10.1038/cddis.2014.223

Subject Category: Experimental Medicine

Original Article

SPAG5 upregulation predicts poor prognosis in cervical cancer patients and alters sensitivity to taxol treatment via the mTOR signaling pathway

L-J Yuan, J-D Li, L Zhang, J-H Wang, T Wan, Y Zhou, H Tu, J-P Yun, R-Z Luo, W-H Jia and M Zheng

Cell Death Dis 5: e1247; doi:10.1038/cddis.2014.222

Subject Category: Cancer

Original Article

Wnt inhibitory factor 1 suppresses cancer stemness and induces cellular senescence

I Ramachandran, V Ganapathy, E Gillies, I Fonseca, S M Sureban, C W Houchen, A Reis and L Queimado

Cell Death Dis 5: e1246; doi:10.1038/cddis.2014.219

Subject Category: Cancer

Review

The pleiotropic roles of sphingolipid signaling in autophagy

Y Li, S Li, X Qin, W Hou, H Dong, L Yao and L Xiong

Cell Death Dis 5: e1245; doi:10.1038/cddis.2014.215

Subject Category: Cancer Metabolism

Original Article

Interconnections between autophagy and the coagulation cascade in hepatocellular carcinoma

K-D Chen, C-C Wang, M-C Tsai, C-H Wu, H-J Yang, L-Y Chen, T Nakano, S Goto, K-T Huang, T-H Hu, C-L Chen and C-C Lin

Cell Death Dis 5: e1244; doi:10.1038/cddis.2014.212

Subject Category: Cancer

Original Article

P53-regulated long non-coding RNA TUG1 affects cell proliferation in human non-small cell lung cancer, partly through epigenetically regulating HOXB7 expression

E-b Zhang, D-d Yin, M Sun, R Kong, X-h Liu, L-h You, L Han, R Xia, K-m Wang, J-s Yang, W De, Y-q Shu and Z-x Wang

Cell Death Dis 5: e1243; doi:10.1038/cddis.2014.201

Subject Category: Cancer

Original Article

Tip30 controls differentiation of murine mammary luminal progenitor to estrogen receptor-positive luminal cell through regulating FoxA1 expression

F Chen, A Li, S Gao, D Hollern, M Williams, F Liu, E A VanSickle, E Andrechek, C Zhang, C Yang, R Luo and H Xiao

Cell Death Dis 5: e1242; doi:10.1038/cddis.2014.224

Subject Category: Cancer

Original Article

Rasfonin, a novel 2-pyrone derivative, induces ras-mutated Panc-1 pancreatic tumor cell death in nude mice

Z Xiao, L Li, Y Li, W Zhou, J Cheng, F Liu, P Zheng, Y Zhang and Y Che

Cell Death Dis 5: e1241; doi:10.1038/cddis.2014.213

Subject Category: Experimental Medicine

Original Article

HKH40A downregulates GRP78/BiP expression in cancer cells

T Kosakowska-Cholody, J Lin, S M Srideshikan, L Scheffer, N I Tarasova and J K Acharya

Cell Death Dis 5: e1240; doi:10.1038/cddis.2014.203

Subject Category: Cancer Metabolism

Original Article

IRE1a constitutes a negative feedback loop with BMP2 and acts as a novel mediator in modulating osteogenic differentiation

F-J Guo, R Jiang, Z Xiong, F Xia, M Li, L Chen and C-J Liu

Cell Death Dis 5: e1239; doi:10.1038/cddis.2014.194

Subject Category: Experimental Medicine

Original Article

Integrated analyses identify the involvement of microRNA-26a in epithelial–mesenchymal transition during idiopathic pulmonary fibrosis

H Liang, Y Gu, T Li, Y Zhang, L Huangfu, M Hu, D Zhao, Y Chen, S Liu, Y Dong, X Li, Y Lu, B Yang and H Shan

Cell Death Dis 5: e1238; doi:10.1038/cddis.2014.207

Subject Category: Experimental Medicine

Original Article

Death-associated protein kinase 1 has a critical role in aberrant tau protein regulation and function

B M Kim, M-H You, C-H Chen, S Lee, Y Hong, Y Hong, A Kimchi, X Z Zhou and T H Lee

Cell Death Dis 5: e1237; doi:10.1038/cddis.2014.216

Subject Category: Neuroscience

Original Article

The heat-shock response co-inducer arimoclomol protects against retinal degeneration in rhodopsin retinitis pigmentosa

D A Parfitt, M Aguila, C H McCulley, D Bevilacqua, H F Mendes, D Athanasiou, S S Novoselov, N Kanuga, P M Munro, P J Coffey, B Kalmar, L Greensmith and M E Cheetham

Cell Death Dis 5: e1236; doi:10.1038/cddis.2014.214

Subject Category: Neuroscience

Original Article

Sec-containing TrxR1 is essential for self-sufficiency of cells by control of glucose-derived H2O2

X Peng, P K Mandal, V O Kaminskyy, A Lindqvist, M Conrad and E S J Arnér

Cell Death Dis 5: e1235; doi:10.1038/cddis.2014.209

Subject Category: Experimental Medicine

Original Article

Knockout of PARG110 confers resistance to cGMP-induced toxicity in mammalian photoreceptors

A Sahaboglu, N Tanimoto, S Bolz, M G Garrido, M Ueffing, M W Seeliger, H Löwenheim, P Ekström and F Paquet-Durand

Cell Death Dis 5: e1234; doi:10.1038/cddis.2014.208

Subject Category: Neuroscience

Top

May 15 2014

Original Article

FoxO mediates APP-induced AICD-dependent cell death

X Wang, Z Wang, Y Chen, X Huang, Y Hu, R Zhang, M S Ho and L Xue

Cell Death Dis 5: e1233; doi:10.1038/cddis.2014.196

Subject Category: Neuroscience

Review

Understanding the roadmaps to induced pluripotency

K Liu, Y Song, H Yu and T Zhao

Cell Death Dis 5: e1232; doi:10.1038/cddis.2014.205

Subject Category: Immunity

Original Article

Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells

Y Sun, X Gu, E Zhang, M-A Park, A M Pereira, S Wang, T Morrison, C Li, J Blenis, V H Gerbaudo, E P Henske and J J Yu

Cell Death Dis 5: e1231; doi:10.1038/cddis.2014.204

Subject Category: Cancer Metabolism

Original Article

β-Lapachone induces programmed necrosis through the RIP1-PARP-AIF-dependent pathway in human hepatocellular carcinoma SK-Hep1 cells

E J Park, K-j Min, T-J Lee, Y H Yoo, Y-S Kim and T K Kwon

Cell Death Dis 5: e1230; doi:10.1038/cddis.2014.202

Subject Category: Cancer

Original Article

HSCARG downregulates NF-κB signaling by interacting with USP7 and inhibiting NEMO ubiquitination

T Li, J Guan, S Li, X Zhang and X Zheng

Cell Death Dis 5: e1229; doi:10.1038/cddis.2014.197

Subject Category: Immunity

Original Article

Ex vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy

T Grabinger, L Luks, F Kostadinova, C Zimberlin, J P Medema, M Leist and T Brunner

Cell Death Dis 5: e1228; doi:10.1038/cddis.2014.183

Subject Category: Experimental Medicine

Original Article

Axl-altered microRNAs regulate tumorigenicity and gefitinib resistance in lung cancer

Y Wang, H Xia, Z Zhuang, L Miao, X Chen and H Cai

Cell Death Dis 5: e1227; doi:10.1038/cddis.2014.186

Subject Category: Cancer

Original Article

Senescence induced by RECQL4 dysfunction contributes to Rothmund–Thomson syndrome features in mice

H Lu, E F Fang, P Sykora, T Kulikowicz, Y Zhang, K G Becker, D L Croteau and V A Bohr

Cell Death Dis 5: e1226; doi:10.1038/cddis.2014.168

Subject Category: Cancer

Original Article

ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS

J C Koch, L Tönges, E Barski, U Michel, M Bähr and P Lingor

Cell Death Dis 5: e1225; doi:10.1038/cddis.2014.191

Subject Category: Neuroscience

Original Article

Interferon consensus sequence-binding protein (ICSBP) promotes epithelial-to-mesenchymal transition (EMT)-like phenomena, cell-motility, and invasion via TGF-β signaling in U2OS cells

J Y Sung, S-Y Park, J H Kim, H G Kang, J H Yoon, Y S Na, Y-N Kim and B-K Park

Cell Death Dis 5: e1224; doi:10.1038/cddis.2014.189

Subject Category: Cancer

Top

May 08 2014

Original Article

Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo

M Signore, F Pelacchi, S di Martino, D Runci, M Biffoni, S Giannetti, L Morgante, M De Majo, E F Petricoin, L Stancato, L M Larocca, R De Maria, R Pallini and L Ricci-Vitiani

Cell Death Dis 5: e1223; doi:10.1038/cddis.2014.188

Subject Category: Cancer

Original Article

Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP+

A K Krug, S Gutbier, L Zhao, D Pöltl, C Kullmann, V Ivanova, S Förster, S Jagtap, J Meiser, G Leparc, S Schildknecht, M Adam, K Hiller, H Farhan, T Brunner, T Hartung, A Sachinidis and M Leist

Cell Death Dis 5: e1222; doi:10.1038/cddis.2014.166

Subject Category: Neuroscience

Original Article

Palmdelphin, a novel target of p53 with Ser46 phosphorylation, controls cell death in response to DNA damage

N Dashzeveg, N Taira, Z-G Lu, J Kimura and K Yoshida

Cell Death Dis 5: e1221; doi:10.1038/cddis.2014.176

Subject Category: Cancer

Original Article

The combination of the prodrugs perforin-CEBPD and perforin-granzyme B efficiently enhances the activation of caspase signaling and kills prostate cancer

C-H Chuang, W-J Wang, C-F Li, C-Y Ko, Y-H Chou, C-P Chuu, T-L Cheng and J-M Wang

Cell Death Dis 5: e1220; doi:10.1038/cddis.2014.106

Subject Category: Cancer

Original Article

Cab45S inhibits the ER stress-induced IRE1-JNK pathway and apoptosis via GRP78/BiP

L Chen, S Xu, L Liu, X Wen, Y Xu, J Chen and J Teng

Cell Death Dis 5: e1219; doi:10.1038/cddis.2014.193

Subject Category: Cancer

Original Article

Zeaxanthin induces Nrf2-mediated phase II enzymes in protection of cell death

X Zou, J Gao, Y Zheng, X Wang, C Chen, K Cao, J Xu, Y Li, W Lu, J Liu and Z Feng

Cell Death Dis 5: e1218; doi:10.1038/cddis.2014.190

Subject Category: Cancer

Original Article

Mitochondrial dysfunction driven by the LRRK2-mediated pathway is associated with loss of Purkinje cells and motor coordination deficits in diabetic rat model

S Yang, C Xia, S Li, L Du, L Zhang and Y Hu

Cell Death Dis 5: e1217; doi:10.1038/cddis.2014.184

Subject Category: Immunity

Original Article

Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells

S Boridy, P U Le, K Petrecca and D Maysinger

Cell Death Dis 5: e1216; doi:10.1038/cddis.2014.182

Subject Category: Cancer

Original Article

Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy

Y Nakamura, K Kanemaru, R Kojima, Y Hashimoto, T Marunouchi, N Oka, T Ogura, K Tanonaka and K Fukami

Cell Death Dis 5: e1215; doi:10.1038/cddis.2014.181

Subject Category: Experimental Medicine

Original Article

Rapamycin reverses insulin resistance (IR) in high-glucose medium without causing IR in normoglycemic medium

O V Leontieva, Z N Demidenko and M V Blagosklonny

Cell Death Dis 5: e1214; doi:10.1038/cddis.2014.178

Subject Category: Experimental Medicine

Original Article

Fas-associated factor (Faf1) is a novel CD40 interactor that regulates CD40-induced NF-κB activation via a negative feedback loop

T Elmetwali, L S Young and D H Palmer

Cell Death Dis 5: e1213; doi:10.1038/cddis.2014.172

Subject Category: Cancer

Original Article

Chaetocin-induced ROS-mediated apoptosis involves ATM–YAP1 axis and JNK-dependent inhibition of glucose metabolism

D Dixit, R Ghildiyal, N P Anto and E Sen

Cell Death Dis 5: e1212; doi:10.1038/cddis.2014.179

Subject Category: Experimental Medicine

Original Article

Identification of prolidase as a high affinity ligand of the ErbB2 receptor and its regulation of ErbB2 signaling and cell growth

L Yang, Y Li and Y Zhang

Cell Death Dis 5: e1211; doi:10.1038/cddis.2014.187

Subject Category: Cancer

Original Article

Pigment epithelium-derived factor expression prolongs survival and enhances the cytotoxicity of low-dose chemotherapy in castration-refractory prostate cancer

T Nelius, D Martinez-Marin, J Hirsch, B Miller, K Rinard, J Lopez, W de Riese and S Filleur

Cell Death Dis 5: e1210; doi:10.1038/cddis.2014.180

Subject Category: Cancer

Original Article

Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation

B I Pérez-Revuelta, M M Hettich, A Ciociaro, C Rotermund, P J Kahle, S Krauss and D A Di Monte

Cell Death Dis 5: e1209; doi:10.1038/cddis.2014.175

Subject Category: Neuroscience

Original Article

Osteopontin deficiency aggravates hepatic injury induced by ischemia–reperfusion in mice

S Patouraux, D Rousseau, A Rubio, S Bonnafous, V J Lavallard, J Lauron, M-C Saint-Paul, B Bailly-Maitre, A Tran, D Crenesse and P Gual

Cell Death Dis 5: e1208; doi:10.1038/cddis.2014.174

Subject Category: Experimental Medicine

Original Article

EphrinB3 blocks EphB3 dependence receptor functions to prevent cell death following traumatic brain injury

M H Theus, J Ricard, S J Glass, L G Travieso and D J Liebl

Cell Death Dis 5: e1207; doi:10.1038/cddis.2014.165

Subject Category: Neuroscience

Top

May 01 2014

Retraction

Retraction to: High-mobility group A1 protein inhibits p53-mediated intrinsic apoptosis by interacting with Bcl-2 at mitochondria

F Esposito, M Tornincasa, A Federico, G Chiappetta, G M Pierantoni and A Fusco

Cell Death Dis 5: e1206; doi:10.1038/cddis.2014.163

Original Article

Prognostic significance of low DICER expression regulated by miR-130a in cervical cancer

L He, H-Y Wang, L Zhang, L Huang, J-D Li, Y Xiong, M-Y Zhang, W-H Jia, J-P Yun, R-Z Luo and M Zheng

Cell Death Dis 5: e1205; doi:10.1038/cddis.2014.127

Subject Category: Cancer

Original Article

Quantitative multi-parametric evaluation of centrosome declustering drugs: centrosome amplification, mitotic phenotype, cell cycle and death

A Ogden, A Cheng, P C G Rida, V Pannu, R Osan, R Clewley and R Aneja

Cell Death Dis 5: e1204; doi:10.1038/cddis.2014.164

Subject Category: Cancer

Original Article

High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy

M Rossi, B Rotblat, K Ansell, I Amelio, M Caraglia, G Misso, F Bernassola, C N Cavasotto, R A Knight, A Ciechanover and G Melino

Cell Death Dis 5: e1203; doi:10.1038/cddis.2014.113

Subject Category: Experimental Medicine

Original Article

Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner

K Mnich, L A Carleton, E T Kavanagh, K M Doyle, A Samali and A M Gorman

Cell Death Dis 5: e1202; doi:10.1038/cddis.2014.173

Subject Category: Neuroscience

Original Article

Reversion of apoptotic resistance of TP53-mutated Burkitt lymphoma B-cells to spindle poisons by exogenous activation of JNK and p38 MAP kinases

M Farhat, A Poissonnier, A Hamze, C Ouk-Martin, J-D Brion, M Alami, J Feuillard and C Jayat-Vignoles

Cell Death Dis 5: e1201; doi:10.1038/cddis.2014.150

Subject Category: Cancer

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