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| Review |
| Interaction of viral proteins with host cell death machinery |
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| David J Granville1,2,b, Chris M Carthy1,b, Decheng Yang1, David WC Hunt1,2 and Bruce M McManus1,a |
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1Cardiovascular Research Laboratory, University of British Columbia, St. Paul's Hospital, Vancouver, British Columbia, Canada
2QLT PhotoTherapeutics Inc., Vancouver, British Columbia, Canada
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aAuthor for correspondence: Department of Pathology and Laboratory Medicine, Cardiovascular Research Laboratory, University of British Columbia, St. Paul's Hospital, 1081 Burrard Street, Vancouver, B.C., Canada V6Z 1Y6tel.: (604) 631-5200; fax: (604) 631-5208; e-mail: mcmanus@unixg.ubc.ca bDavid J. Granville and Chris M. Carthy contributed equally to this work |
Edited by D. Vaux
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| Abstract |
| In recent years, intense research has been directed towards understanding molecular mechanisms involved in viral pathogenesis. It is now known that many viruses manipulate host defense mechanisms to prevent apoptosis in order to maximize viral replication. Towards the end of their replication cycle, certain viruses direct the synthesis of proteins that induce apoptosis or cell lysis thereby facilitating viral release from the cell. The present review summarizes the current understanding of interactions between viral proteins and the host cell death machinery. |
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| Keywords |
| apoptosis; virus; cytopathic effect; viral persistence |
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| Received 23 December 1997; revised 4 March 1998; accepted 13 March 1998 |
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| August 1998, Volume 5, Number 8, Pages 653-659 |
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