Cell Death and Differentiation
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January 1997, Volume 4, Number 1, Pages 4-11
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Review
Surviving Drosophila eye development
Nancy M Boninia

Department of Biology, University of Pennsylvania, Philadelphia, PA 19104-6018, USA; tel: 215-573-9267; fax: 215-898-8780 e mail: nbonini@sas.upenn.edu

aAuthor for correspondence

Abstract

During eye development, cell death interplays dynamically with events of differentiation to achieve the remarkably patterned structure of the fly compound eye. Mutations in genes that affect the normal developmental process can lead to excessive death of progenitor cells, or, alternatively, to the differentiation of supernumerary neurons, pigment and cone cells due to survival of cells that would normally be eliminated. These data reveal that eye development contains cell selection processes: only certain cells are selected to undergo differentiation, and supernumerary cells are actively eliminated by cell death pathways to achieve the highly ordered lattice of the eye. The final number of cells that comprise the eye is controlled through a balance of cell proliferation with proper cell differentiation and removal by cell death.

Keywords

cell death; cell differentiation; cell selection; apoptosis; Drosophila; compound eye

Received 17 June 1999; revised 30 August 1999; accepted 6 September 1999
January 1997, Volume 4, Number 1, Pages 4-11
Table of contents    Previous  Abstract  Next   Article  PDF