Cell Death and Differentiation

FIGURE 2

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The miR-34 family in cancer and apoptosis

H Hermeking

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Figure 2.

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Comparison of the miR-34 family members, miR-34a and miR-34b/c. (a) Structure of genomic loci of the human miR-34a and miR-34b/c genes. White and black boxes represent exons and miRNA hairpins, respectively. Hatched boxes indicate p53-binding sites; CpG islands are represented by thick black lines. The model is not shown to scale. Chromosomal (Chr) locations of the genes are provided. (b) Sequence alignment of the mature miR-34a, miR-34b and miR-34c molecules. The seed sequences are highlighted by gray shading. Asterisks indicate identical nucleotides

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