TABLE OF CONTENTS

Volume 15, Issue 5 (May 2008)

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Editorial

ABT-737, proving to be a great tool even before it is proven in the clinic FREE

D L Vaux

Cell Death Differ 15: 807-808; doi:10.1038/cdd.2008.31

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Review

From sequence to function: using RNAi to elucidate mechanisms of human disease FREE

N M Wolters and J P MacKeigan

Cell Death Differ 15: 809-819; advance online publication, January 18, 2008; doi:10.1038/sj.cdd.4402311

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Original Papers

A novel paradigm for rapid ABT-737-induced apoptosis involving outer mitochondrial membrane rupture in primary leukemia and lymphoma cells FREE

M Vogler, D Dinsdale, X-M Sun, K W Young, M Butterworth, P Nicotera, M J S Dyer and G M Cohen

Cell Death Differ 15: 820-830; advance online publication, February 29, 2008; doi:10.1038/cdd.2008.25

X-linked inhibitor of apoptosis deficiency in the TRAMP mouse prostate cancer model FREE

C Hwang, K A Oetjen, D Kosoff, K J Wojno, M A Albertelli, R L Dunn, D M Robins, K A Cooney and C S Duckett

Cell Death Differ 15: 831-840; advance online publication, February 8, 2008; doi:10.1038/cdd.2008.15

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans  FREE

K Linke, P D Mace, C A Smith, D L Vaux, J Silke and C L Day

Cell Death Differ 15: 841-848; advance online publication, January 25, 2008; doi:10.1038/sj.cdd.4402309

HtrA2 enhances the apoptotic functions of p73 on bax FREE

M Marabese, M Mazzoletti, F Vikhanskaya and M Broggini

Cell Death Differ 15: 849-858; advance online publication, February 8, 2008; doi:10.1038/cdd.2008.7

Interaction of heat-shock protein 90beta isoform (HSP90beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation FREE

C Didelot, D Lanneau, M Brunet, A Bouchot, J Cartier, A Jacquel, P Ducoroy, S Cathelin, N Decologne, G Chiosis, L Dubrez-Daloz, E Solary and C Garrido

Cell Death Differ 15: 859-866; advance online publication, February 1, 2008; doi:10.1038/cdd.2008.5

Redox regulation of anoikis: reactive oxygen species as essential mediators of cell survival FREE

E Giannoni, F Buricchi, G Grimaldi, M Parri, F Cialdai, M L Taddei, G Raugei, G Ramponi and P Chiarugi

Cell Death Differ 15: 867-878; advance online publication, February 8, 2008; doi:10.1038/cdd.2008.3

Secretogranin II: a key AP-1-regulated protein that mediates neuronal differentiation and protection from nitric oxide-induced apoptosis of neuroblastoma cells FREE

L Li, A C Hung and A G Porter

Cell Death Differ 15: 879-888; advance online publication, February 1, 2008; doi:10.1038/cdd.2008.8

Apoptosis induced by replication inhibitors in Chk1-depleted cells is dependent upon the helicase cofactor Cdc45 FREE

R Rodriguez, M E Gagou and M Meuth

Cell Death Differ 15: 889-898; advance online publication, February 1, 2008; doi:10.1038/cdd.2008.4

NG2, a novel proapoptotic receptor, opposes integrin alpha4 to mediate anoikis through PKCalpha-dependent suppression of FAK phosphorylation FREE

N E Joo, T Watanabe, C Chen, M Chekenya, W B Stallcup and Y L Kapila

Cell Death Differ 15: 899-907; advance online publication, February 22, 2008; doi:10.1038/cdd.2008.22

p27Kip1 nuclear localization and cyclin-dependent kinase inhibitory activity are regulated by glycogen synthase kinase-3 in human colon cancer cells FREE

Q Wang, Y Zhou, X Wang and B M Evers

Cell Death Differ 15: 908-919; advance online publication, February 8, 2008; doi:10.1038/cdd.2008.2

The mechanism of peptide-binding specificity of IAP BIR domains FREE

B P Eckelman, M Drag, S J Snipas and G S Salvesen

Cell Death Differ 15: 920-928; advance online publication, February 1, 2008; doi:10.1038/cdd.2008.6

Contributions to Bax insertion and oligomerization of lipids of the mitochondrial outer membrane FREE

S Lucken-Ardjomande, S Montessuit and J-C Martinou

Cell Death Differ 15: 929-937; advance online publication, February 8, 2008; doi:10.1038/cdd.2008.9

Activation mechanism and substrate specificity of the Drosophila initiator caspase DRONC FREE

S J Snipas, M Drag, H R Stennicke and G S Salvesen

Cell Death Differ 15: 938-945; advance online publication, February 29, 2008; doi:10.1038/cdd.2008.23

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