TABLE OF CONTENTS
Volume 15, Issue 2 (February 2008)
Special Issue on Immunity
Cell death is essential for effective immunity.Cells of the adapive immune system are heavily selected during development and those that fail to make the grade,the majority of developing T- and B-lymphocytes,undergo apoptosis. Apoptosis is also used to control the size of mature lympocyte populations,to eliminate autoreachive lymphoctes and is a major mechanism of killing by CTL and NK cells.In this issue of CDD, several reviews focus on the role of death,at the cellular level,in immunity.
See articles marked 
Editorial
Improvement by death in immunity
FREE
S J Martin
Cell Death Differ 15: 221-222; doi:10.1038/sj.cdd.4402293
News and Commentary
Fold up or perish: unfolded protein response and chemotherapy FREE
A Strasser and H Puthalakath
Cell Death Differ 15: 223-225; advance online publication, November 30, 2007; doi:10.1038/sj.cdd.4402279
Reviews
NK cells at the interface between innate and adaptive immunity
FREE
A Moretta, E Marcenaro, S Parolini, G Ferlazzo and L Moretta
Cell Death Differ 15: 226-233; advance online publication, June 1, 2007; doi:10.1038/sj.cdd.4402170
Apoptosis in the development of the immune system
FREE
J T Opferman
Cell Death Differ 15: 234-242; advance online publication, June 15, 2007; doi:10.1038/sj.cdd.4402182
Clearance of apoptotic cells by phagocytes
FREE
L-P Erwig and P M Henson
Cell Death Differ 15: 243-250; advance online publication, June 15, 2007; doi:10.1038/sj.cdd.4402184
Mechanisms of granule-dependent killing
FREE
S P Cullen and S J Martin
Cell Death Differ 15: 251-262; advance online publication, November 2, 2007; doi:10.1038/sj.cdd.4402244
Original Papers
R-Roscovitine simultaneously targets both the p53 and NF-
B pathways and causes potentiation of apoptosis: implications in cancer therapy FREE
A Dey, E T Wong, C F Cheok, V Tergaonkar and D P Lane
Cell Death Differ 15: 263-273; advance online publication, November 2, 2007; doi:10.1038/sj.cdd.4402257
Reduction of endoplasmic reticulum Ca2+ levels favors plasma membrane surface exposure of calreticulin FREE
R Tufi, T Panaretakis, K Bianchi, A Criollo, B Fazi, F Di Sano, A Tesniere, O Kepp, P Paterlini-Brechot, L Zitvogel, M Piacentini, G Szabadkai and G Kroemer
Cell Death Differ 15: 274-282; advance online publication, November 23, 2007; doi:10.1038/sj.cdd.4402275
Identification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screen FREE
S H Y Loh, L Francescut, P Lingor, M Bähr and P Nicotera
Cell Death Differ 15: 283-298; advance online publication, November 16, 2007; doi:10.1038/sj.cdd.4402258
Identification of the prosurvival activity of nerve growth factor on cardiac myocytes FREE
A Caporali, G B Sala-Newby, M Meloni, G Graiani, E Pani, B Cristofaro, A C Newby, P Madeddu and C Emanueli
Cell Death Differ 15: 299-311; advance online publication, November 9, 2007; doi:10.1038/sj.cdd.4402263
Mutant SOD1 detoxification mechanisms in intact single cells FREE
S Ganesan, G Rohde, K Eckermann, K Sroka, M K E Schaefer, C P Dohm, P Kermer, G Haase, F Wouters, M Bähr and J H Weishaupt
Cell Death Differ 15: 312-321; advance online publication, November 9, 2007; doi:10.1038/sj.cdd.4402262
Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways FREE
G P McStay, G S Salvesen and D R Green
Cell Death Differ 15: 322-331; advance online publication, November 2, 2007; doi:10.1038/sj.cdd.4402260
4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG FREE
G Strauss, M-A Westhoff, P Fischer-Posovszky, S Fulda, M Schanbacher, S M Eckhoff, K Stahnke, N Vahsen, G Kroemer and K-M Debatin
Cell Death Differ 15: 332-343; advance online publication, November 23, 2007; doi:10.1038/sj.cdd.4402272
RIP1 links inflammatory and growth factor signaling pathways by regulating expression of the EGFR FREE
D B Ramnarain, R Paulmurugan, S Park, B E Mickey, A Asaithamby, D Saha, M A Kelliher, P Mukhopadhyay, F Banani, C J Madden, P S Wright, S Chakravarty and A A Habib
Cell Death Differ 15: 344-353; advance online publication, November 16, 2007; doi:10.1038/sj.cdd.4402268
RelA/NF-B recruitment on the bax gene promoter antagonizes p73-dependent apoptosis in costimulated T cells FREE
R Cianfrocca, M Muscolini, V Marzano, A Annibaldi, B Marinari, M Levrero, A Costanzo and L Tuosto
Cell Death Differ 15: 354-363; advance online publication, November 23, 2007; doi:10.1038/sj.cdd.4402264
A molecular chaperone inducer protects neurons from ER stress FREE
T Kudo, S Kanemoto, H Hara, N Morimoto, T Morihara, R Kimura, T Tabira, K Imaizumi and M Takeda
Cell Death Differ 15: 364-375; advance online publication, November 30, 2007; doi:10.1038/sj.cdd.4402276
Identification of a novel p53-dependent activation pathway of STAT1 by antitumour genotoxic agents FREE
I Youlyouz-Marfak, N Gachard, C Le Clorennec, I Najjar, F Baran-Marszak, L Reminieras, E May, G W Bornkamm, R Fagard and J Feuillard
Cell Death Differ 15: 376-385; advance online publication, November 9, 2007; doi:10.1038/sj.cdd.4402270
Signaling pathways from membrane lipid rafts to JNK1 activation in reactive nitrogen species-induced non-apoptotic cell death FREE
Y-T Wu, S Zhang, Y-S Kim, H-L Tan, M Whiteman, C-N Ong, Z-G Liu, H Ichijo and H-M Shen
Cell Death Differ 15: 386-397; advance online publication, November 16, 2007; doi:10.1038/sj.cdd.4402273
Notch1 activation reduces proliferation in the multipotent hematopoietic progenitor cell line FDCP-mix through a p53-dependent pathway but Notch1 effects on myeloid and erythroid differentiation are independent of p53 FREE
K Henning, J Heering, R Schwanbeck, T Schroeder, H Helmbold, H Schäfer, W Deppert, E Kim and U Just
Cell Death Differ 15: 398-407; advance online publication, November 30, 2007; doi:10.1038/sj.cdd.4402277
Rap1 is involved in the signal transduction of myelin-associated glycoprotein FREE
J Taniguchi, M Fujitani, M Endo, T Kubo, M Fujitani, F D Miller, D R Kaplan and T Yamashita
Cell Death Differ 15: 408-419; advance online publication, November 30, 2007; doi:10.1038/sj.cdd.4402278
Letters to the Editor
TCL1 promotes blastomere proliferation through nuclear transfer, but not direct phosphorylation, of AKT/PKB in early mouse embryos FREE
M T Fiorenza, S Torcia, S Canterini, A Bevilacqua, M G Narducci, G Ragone, C M Croce, G Russo and F Mangia
Cell Death Differ 15: 420-422; advance online publication, September 28, 2007; doi:10.1038/sj.cdd.4402228
Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress FREE
E Ullman, Y Fan, M Stawowczyk, H-M Chen, Z Yue and W-X Zong
Cell Death Differ 15: 422-425; advance online publication, October 5, 2007; doi:10.1038/sj.cdd.4402234
