Cell Death and Differentiation - Table 3 for article: Identification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screen

FROM:

Identification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screen

S H Y Loh, L Francescut, P Lingor, M Bähr and P Nicotera

Table 3. RNAi knockdown inhibits LPA-induced neurite retraction

Ambion name	Also known as	Full name	Kinase subgroup	ANL/neurite	RefSeq Acc
ADRBK1	BARK1/GRK2	adrenergic, beta, receptor kinase 1	AGC	12.8	NM_001619
AKT1		v-akt murine thymoma viral oncogene homolog 1	AGC	12.65	NM 005163
GRK5	GPRK5	G protein-coupled receptor kinase 5	AGC	14.12	NM_005308
LATS2		LATS, large tumor suppressor, homolog 2 (Drosophila)	AGC	13.41	NM_014572
MAST2		microtubule associated serine/threonine kinase 2	AGC	14.6	NM_015112
MASTL		microtubule associated serine/threonine kinase-like	AGC	13.25	NM 032844
PDPK1	PDK1	3-phosphoinositide dependent protein kinase-1	AGC	13.91	NM_002613, NM_031268
PKN1	PRK1	protein kinase N1	AGC	13.3	NM_002741, NM_213560
PRKCB1	PKC beta	protein kinase C, beta 1	AGC	14.68	NM 002738, NM_212535
PRKCG	PKC gamma	protein kinase C, gamma	AGC	13.76	NM_002739
PRKCI	PKC iota	protein kinase C, iota	AGC	14.89	NM_002740
PRKY		protein kinase, Y-linked	AGC	15.12	NM 002760
ROCK1		Rho-associated, coiled-coil containing protein kinase 1	AGC	14.18	NM_005406
STK32B	YANK2	serine/threonine kinase 32B	AGC	13.51	NM_018401
STK38L	NDR2	serine/threonine kinase 38 like	AGC	13.43	NM_015000
ADCK2	CABC1	aarF domain containing kinase 2	ATYPICAL	12.7	NM 052853
ADCK4	CABC1	aarF domain containing kinase 4	ATYPICAL	14.08	NM_024876
CABC1	ADCK3	chaperone, ABC1 activity of bc1 complex like (S. pombe)	ATYPICAL	12.62	NM_020247
MIDORI	ALPK3		ATYPICAL	13.73	NM 020778
FASTK			ATYPICAL	12.6	NM_006712, NM_025096
HUNK		hormonally upregulated Neu-associated kinase	CAMK	12.98	NM_014586
KIAA0999	QSK		CAMK	13.71	NM_025164
MKNK2	MNK2	MAP kinase interacting serine/threonine kinase 2	CAMK	14.83	NM 017572, NM_199054
PHKG1		phosphorylase kinase, gamma 1 (muscle)	CAMK	12.63	NM_006213
PSKH2		protein serine kinase H2	CAMK	14.37	NM_033126
STK22D	TSSK1	serine/threonine kinase 22D (spermiogenesis associated)	CAMK	13.7	NM 032028
CDC2	CDK1	cell division cycle 2, G1 to S and G2 to M	CMGC	12.96	NM_001786, NM_033379
HIPK1		homeodomain interacting protein kinase 1	CMGC	13.09	NM_152696, NM_181358, NM_198268, NM_198269
SCYL1		SCY1-like 1 (S. cerevisiae)	OTHER	13.1	NM_020680
SGK	CLIK1	serum/glucocorticoid regulated kinase	OTHER	12.72	NM_005627
TBK1		TANK-binding kinase 1	OTHER	12.48	NM 013254
ULK1		unc-51-like kinase 1 (C. elegans)	OTHER	14.41	NM_003565
ULK2		unc-51-like kinase 2 (C. elegans)	OTHER	12.61	NM_014683
PTK9L		PTK9L protein tyrosine kinase 9-like (A6-related protein)	OTHER	12.93	NM 007284
PAK6		p21(CDKN1A)-activated kinase 6	STE	12.03	NM_020168
SLK		STE20-like kinase (yeast)	STE	13.54	NM_014720
STK10	LOK	serine/threonine kinase 10	STE	13.19	NM_005990.
MAP4K4	HGK/NIK	mitogen-activated protein kinase kinase kinase kinase 4	STE	13.44	NM_004834, NM_145686 NM_145687
EGFR		epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog. avian)	TK	14.83	NM_005228, NM_201282, NM_201283, NM_201284
FGFR1		fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)	TK	13.35	NM_000604. NM_015850 NM_023105, NM_023106
FGFR4		fibroblast growth factor receptor 4	TK	14.48	NM_002011, NM_022963 NM_213647
FLT1	VEGFR1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	TK	13.4	NM_002019
HCK		hemopoietic cell kinase	TK	12.77	NM_002110
LTK		leukocyte tyrosine kinase	TK	13.51	NM 002344, NM_206961
MST1R	RON	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	TK	13.76	NM_002447
NTRK1	TRKA	neurotrophic tyrosine kinase, receptor, type 1	TK	13.75	NM_002529
NTRK3	TRKC	neurotrophic tyrosine kinase, receptor, type 3	TK	12.28	NM_002530
PPGFRB		platelet-derived growth factor receptor, beta polypeptide	TK	12.22	NM 002609
PTK2B	PYK2	PTK2B protein tyrosine kinase 2 beta	TK	13.01	NM_004103, NM_173174, NM_173175, NM_173176
PTK6	BRK	PTK6 protein tyrosine kinase 6	TK	13.54	NM 005975
PTK7	CCK4	PTK7 protein tyrosine kinase 7	TK	13.83	NM_002821, NM_152880 NM_152881, NM_152882
SRMS	SRM	src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites	TK	13.39	NM_080823.
TEC		tec protein tyrosine kinase	TK	14.8	NM_003215,
TYR03	SKY	TYR03 protein tyrosine kinase	TK	13.43	NM_006293
AMHR2	MIAR2	anti-Mullerian hormone receptor, type II	TKL	13.57	NM_020547
ILK		integrin-linked kinase	TKL	13.41	NM 004517
IRAK3		interieukin-l receptor-associated kinase 3	TKL	12.61	NM_007199
CERK		ceramide kinase		14.1	NM_022766, NM_182661
DAB2		disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)		13.39	NM_001343
DGKD		diacylglycerol kinase, delta I30 kDa		12.32	NM_003648, NM_152879
DGKO		diacylglycerol kinase, theta 110 kDa		14.16	NM_001347
FN3KRP		fructosamine-3-kinase-related protein		12.36	NM 024619
GK2		glycerol kinase 2		12.26	NM_033214
IHPK1		inositol hcxaphosphate kinase 1		14.52	NM_153273
NME3		non-metastatic cells 3		12.66	NM 002513
PGK2		phosphoglycerate kinase 2		13.15	NM_138733
PRPS2		phosphoribosyl pyrophosphate synthetase 2		13.92	NM_002765
TSKS		testis-specific kinase substrate		13.11	NM_021733

AGC, containing PKA, PKG, PKC families; ATYPICAL, 'atypical' kinases with no sequence similarity to typical kinases but are known or predicted to have enzymatic activity; CAMK, calcium/calmodulin-dependent protein kinase; CMGC, containing CDK, MAPK, GSK3, CLK families; OTHER, the Other group contains several kinase families that do not fit within any of the other main kinase groups; STE, homologues of yeast sterile 7, sterile 11, sterile 20 kinases; TK, tyrosine kinase; TKL, tyrosine kinase-like.

The table shows 79 protein kinases with RNAi phenotype of inhibiting LPA-induced neurite retraction in our assay condition. These candidates were grouped according to the subgroup classification in the KINOME (http://kinase.com/human/kinome/).⁴³ ANL/neurite (average neurite length per neurite) represents average neurite length by three (underlined candidates) or two (un-underlined candidates) independent siRNAs calculated from two rounds of screens

Previous tableFigure and tables index

BACK TO ARTICLE

TABLE 3

Identification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screen

Table 3. RNAi knockdown inhibits LPA-induced neurite retraction