Cell Death and Differentiation

FIGURE 7

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Aberrant quality control in the endoplasmic reticulum impairs the biosynthesis of pulmonary surfactant in mice expressing mutant BiP

N Mimura, H Hamada, M Kashio, H Jin, Y Toyama, K Kimura, M Iida, S Goto, H Saisho, K Toshimori, H Koseki and T Aoe

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Figure 7.

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SP-A and SP-C in lungs from BiP mutants. (a) Costaining of lungs from P1 wild-type (+/+) and mutant (B/B) mice with anti-SP-A (brown staining, right panels) and monoclonal anti-KDEL or anti-HA (shown in green in different panels). (b) Costaining of lungs from P1 wild types (+/+) and mutants (B/B) with anti-SP-C (proSP-C; right panels) and anti-KDEL or anti-HA. Arrows indicate colocalization of SP-A or SP-C with KDEL-containing chaperones in wild-type type II cells as well as colocalization of SP-A with mutant BiP in B/B type II cells

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