Special issue on Cellular and molecular mechanisms of tissue damage and repair

For multicellular organisms, the process of death is inseparable from life. The process of cell death occurs continuously and is a fundamental mechanism for development and, perversely, for survival. To date, at least 10 distinct modes of homeostatic cell death (e.g. anoikis, autophagy, caspase-independent apoptosis, Wallerian degeneration, excitotoxicity, cornification etc.) have been identified. Further understanding of death mechanisms could lead to an improvement of our knowledge of survival and protection and, therefore, in our understanding of the aetiology of certain diseases. This special issue comprises a collection of papers written by some of the renowned speakers at the Academia Europaea & Klaus Tschira Foundation's international symposium in March 2007.

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TABLE OF CONTENTS

Volume 14, Issue 7 (July 2007)

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Editorial

Janus a god with two faces: death and survival utilise same mechanisms conserved by evolution   FREE

P Nicotera, O H Petersen, G Melino and A Verkhratsky

Cell Death Differ 14: 1235-1236; doi:10.1038/sj.cdd.4402161

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News and Commentaries

Cell death modalities: classification and pathophysiological implications   FREE

L Galluzzi, M C Maiuri, I Vitale, H Zischka, M Castedo, L Zitvogel and G Kroemer

Cell Death Differ 14: 1237-1243; advance online publication, April 13, 2007; doi:10.1038/sj.cdd.4402148

Role of cardiolipin in cytochrome c release from mitochondria   FREE

M Ott, B Zhivotovsky and S Orrenius

Cell Death Differ 14: 1243-1247; advance online publication, April 13, 2007; doi:10.1038/sj.cdd.4402135

Atg5 and Bcl-2 provide novel insights into the interplay between apoptosis and autophagy   FREE

S Luo and D C Rubinsztein

Cell Death Differ 14: 1247-1250; advance online publication, April 13, 2007; doi:10.1038/sj.cdd.4402149

Roles and mechanisms of action of the Nrf2 transcription factor in skin morphogenesis, wound repair and skin cancer   FREE

T A Beyer, U auf dem Keller, S Braun, M Schäfer and S Werner

Cell Death Differ 14: 1250-1254; advance online publication, March 23, 2007; doi:10.1038/sj.cdd.4402133

Matrix metalloproteinase-9 in glutamate-dependent adult brain function and dysfunction   FREE

P Michaluk and L Kaczmarek

Cell Death Differ 14: 1255-1258; advance online publication, April 13, 2007; doi:10.1038/sj.cdd.4402141

Cardiac repair by stem cells   FREE

A Sánchez and J García-Sancho

Cell Death Differ 14: 1258-1261; advance online publication, April 13, 2007; doi:10.1038/sj.cdd.4402146

Mitochondrial dysfunction in Parkinson's disease   FREE

A H V Schapira

Cell Death Differ 14: 1261-1266; advance online publication, April 27, 2007; doi:10.1038/sj.cdd.4402160

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Reviews

Mitochondrial Ca2+ as a key regulator of cell life and death   FREE

M Giacomello, I Drago, P Pizzo and T Pozzan

Cell Death Differ 14: 1267-1274; advance online publication, April 13, 2007; doi:10.1038/sj.cdd.4402147

A cut short to death: Parl and Opa1 in the regulation of mitochondrial morphology and apoptosis   FREE

L Pellegrini and L Scorrano

Cell Death Differ 14: 1275-1284; advance online publication, April 20, 2007; doi:10.1038/sj.cdd.4402145

Calcium signalling and pancreatic cell death: apoptosis or necrosis?   FREE

D N Criddle, J V Gerasimenko, H K Baumgartner, M Jaffar, S Voronina, R Sutton, O H Petersen and O V Gerasimenko

Cell Death Differ 14: 1285-1294; advance online publication, April 13, 2007; doi:10.1038/sj.cdd.4402150

Ion channels in death and differentiation of prostate cancer cells   FREE

N Prevarskaya, R Skryma, G Bidaux, M Flourakis and Y Shuba

Cell Death Differ 14: 1295-1304; advance online publication, May 4, 2007; doi:10.1038/sj.cdd.4402162

S-Nitrosylation and uncompetitive/fast off-rate (UFO) drug therapy in neurodegenerative disorders of protein misfolding   FREE

T Nakamura and S A Lipton

Cell Death Differ 14: 1305-1314; advance online publication, April 13, 2007; doi:10.1038/sj.cdd.4402138

Adenosine, an endogenous distress signal, modulates tissue damage and repair   FREE

B B Fredholm

Cell Death Differ 14: 1315-1323; advance online publication, March 30, 2007; doi:10.1038/sj.cdd.4402132

Glia: the fulcrum of brain diseases   FREE

C Giaume, F Kirchhoff, C Matute, A Reichenbach and A Verkhratsky

Cell Death Differ 14: 1324-1335; advance online publication, April 13, 2007; doi:10.1038/sj.cdd.4402144

Migration, fate and in vivo imaging of adult stem cells in the CNS   FREE

E Syková and P Jendelová

Cell Death Differ 14: 1336-1342; advance online publication, March 30, 2007; doi:10.1038/sj.cdd.4402140

Reversal of renal disease: is it enough to inhibit the action of angiotensin II?   FREE

J-C Dussaule and C Chatziantoniou

Cell Death Differ 14: 1343-1349; advance online publication, March 30, 2007; doi:10.1038/sj.cdd.4402143

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Original Papers

Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma FREE

K Becker, N D Marchenko, M Maurice and U M Moll

Cell Death Differ 14: 1350-1360; advance online publication, March 23, 2007; doi:10.1038/sj.cdd.4402126

Tumour necrosis factor-alpha inhibits adipogenesis via a beta-catenin/TCF4(TCF7L2)-dependent pathway FREE

W P Cawthorn, F Heyd, K Hegyi and J K Sethi

Cell Death Differ 14: 1361-1373; advance online publication, April 20, 2007; doi:10.1038/sj.cdd.4402127

Siva is an apoptosis-selective p53 target gene important for neuronal cell death FREE

S B R Jacobs, S Basak, J I Murray, N Pathak and L D Attardi

Cell Death Differ 14: 1374-1385; advance online publication, April 20, 2007; doi:10.1038/sj.cdd.4402128

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Letter to the Editor

The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis FREE

C Hetz, P Thielen, J Fisher, P Pasinelli, R H Brown, S Korsmeyer and L Glimcher

Cell Death Differ 14: 1386-1389; advance online publication, May 18, 2007; doi:10.1038/sj.cdd.4402166

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Meeting Report

The post-genomic era: workshop on chromatin immunoprecipitation-related techniques FREE

G Blandino, M Fanciulli, M Levrero and G Piaggio

Cell Death Differ 14: 1390-1391; advance online publication, May 18, 2007; doi:10.1038/sj.cdd.4402164

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