Cell Death and Differentiation

FIGURE 12

FROM:

The molecular basis of eucaryotic transcription

R D Kornberg Nobel Lecture, December 8, 2006 by

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Figure 12.

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Release of RNA transcript from DNA–RNA hybrid revealed in the structure of an RNA pol II transcribing complex. The upstream end of the DNA–RNA hybrid helix, 7–10 residues from the active center, is shown on the left, with distances between the DNA and RNA bases indicated. The entire DNA–RNA hybrid helix is shown on the right, along with protein loops involved in helix melting (rudder and lid) and stabilization (fork loop)

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