Cell Death and Differentiation

FIGURE 2

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Caspase function in programmed cell death

S Kumar

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Figure 2.

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The initiator and effector caspases in C. elegans, Drosophila and mammals. Only caspases with potential or demonstrated role in apoptosis are shown. The small and large subunits, and the protein–protein interaction motifs (such as CARD and DED) are shown. Note that the long prodomain in STRICA does not contain any protein–protein interaction motif(s). The relative lengths of various domains and subunits are not drawn to size and only serve as a guide here to demonstrate the various types of apoptotic caspases found in C. elegans, Drosophila and mammals

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