TABLE 1
FROM:
Caspases in cell survival, proliferation and differentiation
M Lamkanfi, N Festjens, W Declercq, T Vanden Berghe and P Vandenabeele
BACK TO ARTICLETable 1. Overview of non-apoptotic caspase functions
| Caspase | Phenotype | References |
|---|---|---|
| Caspase-1 | Cytokine maturation | 97, 98 |
| Induction of pyroptosis | 99, 100 | |
Prodomain-mediated NF- B activation | 27 | |
| Caspase-2 | Switch between stress-induced NF-B activation and induction of apoptosis | 6, 31, 32 |
| Prodomain-mediated NF-B activation | 24 | |
| Caspase-3 | Inhibition of B-cell proliferation | 59 |
| Inhibition of MHC II expression and dendritic cell maturation | 79 | |
| Proliferation of forebrain cells and keratinocytes | 57, 71 | |
| Differentiation of lens epithelial cells, erythroblasts, platelets, myoblasts, osteoblasts and neural stem cells | 56, 66, 68, 75, 76, 77 | |
| Caspase-4 | Not determined | |
| Caspase-5 | Maturation of pro-inflammatory cytokines in the inflammasome | 101 |
| Caspase-6 | Not determined | |
| Caspase-7 | Not determined | |
| Caspase-8 | Proliferation of T, B and NK cells | 14, 39, 40 |
| NF-B activation following TcR-, TNF-, TLR-4- and Apo2/TRAIL-stimulation | 5, 12, 16 | |
| dsRNA-induced NF-B activation via its prodomain | 25, 26 | |
| Differentiation of monocytes into macrophages | 72, 73 | |
| Differentiation of placental villous trophoblasts | 74 | |
| Caspase-9 | Not determined | |
| Caspase-10 | dsRNA-induced NF-B activation via its prodomain | 25, 26 |
| Caspase-11 | Maturation of pro-inflammatory cytokines | 102 |
| Caspase-12 | Attenuation of inflammation and susceptibility to sepsis | 94, 95 |
| Caspase-14 | Terminal differentiation of keratinocytes? | 70, 103 |
