Cell Death and Differentiation

FIGURE 2

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Drosophila homolog of APP-BP1 (dAPP-BP1) interacts antagonistically with APPL during Drosophila development

H-J Kim, S-H Kim, S-O Shim, E Park, C Kim, K Kim, M A Tanouye and J Yim

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Figure 2.

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dAPP-BP1 mutant phenotypes and developmental expression. (a) The adult eyes of w ey-flp;; P{Ubi-GFP}61EF P{neoFRT}80B/dAPP-BP1 Ex183 P{neoFRT}80B. (b) The adult eyes of w ey-flp;; P{Ubi-GFP}61EF P{neoFRT}80B/dAPP-BP1 Ex62 P{neoFRT}80B. The dAPP-BP1 Ex183 clones containing white ommatidia exist in (a), compared to (b) in which dAPP-BP1 Ex62 clones (marked by white ommatidia) are absent, leaving a defective eye that contains dAPP-BP1 Ex62/+ or +/+ cells in red ommatidia. (c) Wild-type brain and eye imaginal disc. (d) dAPP-BP1 Ex62/Df (3L) lxd6 eye discs are almost demolished. (e) mRNA expression analysis in third instar larvae (RT-PCR): dAPP-BP1 mRNA is not expressed in dAPP-BP1 Ex62 homozygotes. (f) Quantitative RT-PCR analysis of dAPP-BP1 expression during development. As control, transcripts of rp49 were amplified. dAPP-BP1 transcripts can be detected during all developmental stages

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