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Cell Death and Differentiation (2007) 14, 3–9. doi:10.1038/sj.cdd.4402058; published online 27 October 2006

p53 downstream target genes and tumor suppression: a classical view in evolution

L M Rozan1 and W S El-Deiry1

1Laboratory of Molecular Oncology and Cell Cycle Regulation, Departments of Medicine (Hematology/Oncology), Genetics, and Pharmacology, The Institute for Translational Medicine and Therapeutics, The Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 USA

Correspondence: WS El-Deiry, Laboratory of Molecular Oncology and Cell Cycle Regulation, Departments of Medicine (Hematology/Oncology), Genetics, and Pharmacology, The Institute for Translational Medicine and Therapeutics, The Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, 415 Curie Blvd., CRB 437, Philadelphia, PA 19104, USA. Tel: 215 898 9015; Fax: 215 573 9139; E-mail: wafik@mail.med.upenn.edu

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