Cell Death and Differentiation

TABLE 1

FROM:

Roles for NF-kappaB in nerve cell survival, plasticity, and disease

M P Mattson and M K Meffert

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Table 1. Behavioral phenotypes of NF-kappaB-deficient mice

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Deficiency Cognitive tests Other behavior Additional phenotype References
p50Impaired acquisition of active avoidance to footshock in a massed trial, normal retentionNA  27
p50NADecreased anxietya in open maze, and novel object testDecreased weight 28
p65Delayed spatial and normal cued learning in distributed radial maze trials, normal exploratory activityNormal exploratory activityNA 15
c-RelImpaired contextual and normal associative fear memoryHypoactive in open-field test, normal anxietya behaviorNormal nociception 7

a Anxiety is assessed by time spent in anxiogenic settings such as the center of an open-field, in an open versus a closed maze arm, or in close proximity to a novel object

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