Review
Cell Death and Differentiation (2006) 13, 785–797. doi:10.1038/sj.cdd.4401888; published online 10 March 2006
NF-
B and the regulation of hematopoiesis
V Bottero1, S Withoff1 and I M Verma1
1Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA
Correspondence: IM Verma, Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Tel: +1 858 453 4100 ex.1462; Fax: +1 858 558 7454; E-mail: verma@salk.edu
Received 21 November 2005; Revised 19 January 2006; Accepted 19 January 2006; Published online 10 March 2006.
Abstract
This review will focus on the role of nuclear factor 
B (NF-B) signaling in hematopoietic differentiation. We will also discuss several hematopoietic pathologies associated with deregulation of NF-B and their potential therapies.
Keywords:
NF-B, IB, IKK, hematopoiesis, myelopoiesis, lymphopoiesis, disease
Abbreviations:
BAFF, B cells activation factor; BAFF-R, B cells activation factor receptor; BCR, B Cell Receptor; bm-PMN, bone marrow polymorphonuclear neutrophilic granulocytes; CFU-GEMM, granulocyte/erythroid/monocyte/macrophage colony-forming units; DC, dendritic cell; DN, dominant negative; FTOC, fetal thymic organ cultures; GM-CSF, granulocyte–macrophage colony-stimulating factor; GVHD, graft-versus-host disease; HED-ID, hypohidrotic ectodermal dysplasia with immune deficiency; IFN, interferon; Ig, immunoglobuline; IKK, IB kinase; IL, interleukin; IB, inhibitor of B; LDL, low-density lipoprotein; LDLR, low-density lipoprotein receptor; LPS, lipopolysaccharide; MY, metamyelocyte; MHC, major histocompatibility; NBD, Nemo binding domain; NEMO, NF-B essential modulator; NF-B, nuclear factor B; NIK, NF-B inducing kinase; NK cells, natural killer cells; NKT, natural killer-like T cells; NOD, non-obese diabetic; PAI-2, plasminogen activator inhibitor 2; PDTC, pyrrolidine dithiocarbamate; PMA, phorbol myristate acetate; PM, promyelocyte; RA, rheumatoid arthritis; RANK, receptor activator of NF-B; RANKL, receptor activator of NF-B ligand; TAK1, transforming-growth-factor 
-activated kinase 1; TCR, T-cell receptor; TLR, Toll-like receptor; TNF, tumor necrosis factor; TRAF, TNF receptor-associated factor; TRAP, tartrate-resistant acid phosphatase
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated
REVIEWS
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems
Nature Reviews Immunology Review (01 Apr 2007)
The pathogenesis of MALT lymphomas: where do we stand?
Leukemia Review
NEWS AND VIEWS
At once harmful and beneficial: the dual properties of NF-κB
Nature Immunology News and Views (01 Sep 2006)
Gatekeeper mechanisms for immature B cells
Nature Immunology News and Views (01 Oct 2002)
RESEARCH
The EMBO Journal Article (02 Jan 2003)
