Cell Death and Differentiation

FIGURE 2

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Dual function of membrane-bound heat shock protein 70 (Hsp70), Bag-4, and Hsp40: protection against radiation-induced effects and target structure for natural killer cells

M Gehrmann, J Marienhagen, H Eichholtz-Wirth, E Fritz, J Ellwart, M Jäättelä, T Zilch and G Multhoff

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Figure 2.

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Cell surface expression of Hsp70 and Bag-4 was upregulated on Hsp70 low-expressing colon (CX-) and pancreas (Colo-) carcinoma sublines after nonlethal italic gamma-irradiation. The percentage of positively stained cells (left part) and the mean flurorescence intensity (right part) of Hsp70 and Bag-4 were determined by flow cytometry on untreated (ctrl) and italic gamma-irradiated (1 times 10 Gy) colon (a: CX+/CX-) and pancreas (b: Colo+/Colo-) carcinoma cells, using Bag-4-specific antibodies recognizing the C-terminal localized BAG domain (Table 1). Histograms represent mean values of eight (Hsp70) and seven (Bag-4) independent experimentsplusminusS.E.; significant differences are indicated as P-values in each histogram

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