Cell Death and Differentiation

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Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs

T M Ganten, T L Haas, J Sykora, H Stahl, M R Sprick, S C Fas, A Krueger, M A Weigand, A Grosse-Wilde, W Stremmel, P H Krammer and H Walczak

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Figure 1.

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Dose dependency of TRAIL-induced apoptosis in various HCC cell lines. Different HCC cell lines HepG2 (circle), HepG2-TR (Delta) and Hep3b (square) were treated with 12–1000 ng/ml TRAIL and analysed after 24 h for subdiploid DNA content.72 Data are shown as the percent apoptosis with S.D. (three wells each condition). Three independent experiments with similar results have been performed

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