Cell Death and Differentiation

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Paradigm shift in neuroprotective drug development: clinically tolerated NMDA receptor inhibition by memantine

S A Lipton and H-SV Chen

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Figure 1.

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Open-channel blockers such as memantine inhibit the NMDAR preferentially when it is excessively (pathologically) activated but have little if any effect on normal synaptic transmission. (Glu=glutamate; Gly=glycine; NR1 and NR2 are subunits of the NMDAR that is probably composed of a tetramer of subunits)

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