This new web focus from Cell, Death & Differentiation highlights some of the latest research and thinking on programmed necrosis (necroptosis) from some of the world's most recognised experts. Necroptosis is a form of programmed cell death that depends on the activation of receptor interacting protein kinase-1 (RIPK1) and RIPK3 by receptors such as tumor necrosis factor (TNF) receptor-1. This focus reflects the current interest in this important and fast developing research area - an area which has strong potential to make a significant impact on the development of new treatments for multiple human diseases.

Figure 1

Image Courtesy of Susana Orozco and Andrew Oberst


Editorial Material

RIP kinase 3 in necroptosis: does it take two or more to kill?  FREE

C Kim and M Pasparakis

Cell Death and Differentiation 21: 1505-1507; Published online, 08 September 2014; doi:10.1038/cdd.2014.100



Cancer therapy in the necroptosis era  Open

Z Su, Z Yang, L Xie, J P DeWitt and Y Chen

Cell Death and Differentiation 23: 748-756; Published online, 26 February 2016; doi:10.1038/cdd.2016.8

RIP kinases: key decision makers in cell death and innate immunity  FREE

F Humphries, S Yang, B Wang and P N Moynagh

Cell Death and Differentiation 22: 225-236; Published online, 22 August 2014; doi:10.1038/cdd.2014.126



RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury  Open

K Newton, D L Dugger, A Maltzman, J M Greve, M Hedehus, B Martin-McNulty, R A D Carano, T C Cao, N van Bruggen, L Bernstein, W P Lee, X Wu, J DeVoss, J Zhang, S Jeet, I Peng, B S McKenzie, M Roose-Girma, P Caplazi, L Diehl, J D Webster and D Vucic

Cell Death and Differentiation 23: 1565-1576; Published online, 13 May 2016; doi:10.1038/cdd.2016.46

Defective immunogenic cell death of HMGB1-deficient tumors: compensatory therapy with TLR4 agonists  FREE

T Yamazaki, D Hannani, V Poirier-Colame, S Ladoire, C Locher, A Sistigu, N Prada, S Adjemian, J PP Catani, M Freudenberg, C Galanos, F André, G Kroemer and L Zitvogel

Cell Death and Differentiation 21: 69-78; Published online, 28 June 2013; doi:10.1038/cdd.2013.72

RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis  FREE

S Orozco, N Yatim, M R Werner, H Tran, S Y Gunja, S WG Tait, M L Albert, D R Green and A Oberst

Cell Death and Differentiation 21: 1511-1521; Published online, 06 June 2014; doi:10.1038/cdd.2014.76

Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration  FREE

Y Murakami, H Matsumoto, M Roh, A Giani, K Kataoka, Y Morizane, M Kayama, A Thanos, S Nakatake, S Notomi, T Hisatomi, Y Ikeda, T Ishibashi, K M Connor, J W Miller and D G Vavvas

Cell Death and Differentiation 21: 270-277; Published online, 16 August 2013; doi:10.1038/cdd.2013.109

Distinct roles of RIP1–RIP3 hetero- and RIP3–RIP3 homo-interaction in mediating necroptosis  FREE

X-N Wu, Z-H Yang, X-K Wang, Y Zhang, H Wan, Y Song, X Chen, J Shao and J Han

Cell Death and Differentiation 21: 1709-1720; Published online, 06 June 2014; doi:10.1038/cdd.2014.77

RIPK1- and RIPK3-induced cell death mode is determined by target availability  FREE

W D Cook, D M Moujalled, T J Ralph, P Lock, S N Young, J M Murphy and D L Vaux

Cell Death and Differentiation 21: 1600-1612; Published online, 06 June 2014; doi:10.1038/cdd.2014.70

Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis  FREE

D A Rodriguez, R Weinlich, S Brown, C Guy, P Fitzgerald, C P Dillon, A Oberst, G Quarato, J Low, J G Cripps, T Chen and D R Green

Cell Death and Differentiation 23: 76-88; Published online, 29 May 2015; doi:10.1038/cdd.2015.70

Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production  FREE

C J Kearney, S P Cullen, G A Tynan, C M Henry, D Clancy, E C Lavelle and S J Martin

Cell Death and Differentiation 22: 1313-1327; Published online, 23 January 2015; doi:10.1038/cdd.2014.222

TRAF2 is a biologically important necroptosis suppressor  FREE

S L Petersen, T T Chen, D A Lawrence, S A Marsters, F Gonzalvez and A Ashkenazi

Cell Death and Differentiation 22: 1846-1857; Published online, 17 April 2015; doi:10.1038/cdd.2015.35

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