FOCUS

Showcasing China

This new web focus from Cell Death & Differentiation, Cell Death & Disease and Cell Death Discovery highlights some of the latest research from China in the related fields covered by those journals, including cell death, stem cells, autophagy, and tumor biology. In the last 30 years, China has experienced a booming economy, which has resulted in a huge increase in the funds channelled into biomedical research. More importantly, there is a steady increase in the number of talented young scientists who have trained in western countries and are returning to China. We are now witnessing the fastest development of biomedical research in China. This focus highlights the current progress in several important research areas, from mechanism-driven basic research to studies with translational potential.

这个网站焦点摘编了近年中国在 Cell Death & DifferentiationCell Death & DiseaseCell Death Discovery 杂志上发表的的文章。这些论文涵盖了细胞死亡、干细胞、细胞自噬,以及肿瘤生物学等领域。过去的30年,中国的经济经历了一个蓬勃发展期,投入到生物医学研究的基金也大量增加。更重要的是,一批有才华的年轻科学家在西方国家接受良好科研培训后返回中国,而且回国的科研工作者数量逐年稳定增加。我们正在见证生物医学研究在中国突飞猛进的发展。这一焦点突出了中国生物医学领域,从机制驱动的基础工作到具有转化潜能的研究等几个重要研究方向的进展。

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Reviews

Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?  Open

Q Chen, P Shou, C Zheng, M Jiang, G Cao, Q Yang, J Cao, N Xie, T Velletri, X Zhang, C Xu, L Zhang, H Yang, J Hou, Y Wang and Y Shi

Cell Death and Differentiation 23: 1128-1139; Published online, 12 February 2016; doi:10.1038/cdd.2015.168

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Research

Tousled-like kinase mediated a new type of cell death pathway in Drosophila  FREE

Y Zhang, R Cai, R Zhou, Y Li and L Liu

Cell Death and Differentiation 23: 146-157; Published online, 19 June 2015; doi:10.1038/cdd.2015.77

The LIM protein Ajuba promotes adipogenesis by enhancing PPARγ and p300/CBP interaction  FREE

Q Li, H Peng, H Fan, X Zou, Q Liu, Y Zhang, H Xu, Y Chu, C Wang, K Ayyanathan, F J Rauscher, K Zhang and Z Hou

Cell Death and Differentiation 23: 158-168; Published online, 26 June 2015; doi:10.1038/cdd.2015.83

Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice  FREE

Z Tu, Q Wang, T Cui, J Wang, H Ran, H Bao, J Lu, B Wang, J P Lydon, F DeMayo, S Zhang, S Kong, X Wu and H Wang

Cell Death and Differentiation 23: 169-181; Published online, 17 July 2015; doi:10.1038/cdd.2015.98

Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization  FREE

H Li, Y Ruan, K Zhang, F Jian, C Hu, L Miao, L Gong, L Sun, X Zhang, S Chen, H Chen, D Liu and Z Song

Cell Death and Differentiation 23: 380-392; Published online, 07 August 2015; doi:10.1038/cdd.2015.102

Ube2s regulates Sox2 stability and mouse ES cell maintenance  FREE

J Wang, Y Zhang, J Hou, X Qian, H Zhang, Z Zhang, M Li, R Wang, K Liao, Y Wang, Z Li, D Zhong, P Wan, L Dong, F Liu, X Wang, Y Wan, W Xiao and W W Zhang

Cell Death and Differentiation 23: 393-404; Published online, 21 August 2015; doi:10.1038/cdd.2015.106

Unexpected requirement for a binding partner of the syntaxin family in phagocytosis by murine testicular Sertoli cells  FREE

Y-s Dong, W-g Hou, Y Li, D-b Liu, G-z Hao, H-f Zhang, J-c Li, J Zhao, S Zhang, G-b Liang and W Li

Cell Death and Differentiation 23: 787-800; Published online, 23 October 2015; doi:10.1038/cdd.2015.139

Focused screening of mitochondrial metabolism reveals a crucial role for a tumor suppressor Hbp1 in ovarian reserve  Open

Z Dong, M Huang, Z Liu, P Xie, Y Dong, X Wu, Z Qu, B Shen, X Huang, T Zhang, J Li, J Liu, T Yanase, C Zhou and Y Xu

Cell Death and Differentiation 23: 1602-1614; Published online, 20 May 2016; doi:10.1038/cdd.2016.47

Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans  FREE

Z Li, W Zhang, Y Chen, W Guo, J Zhang, H Tang, Z Xu, H Zhang, Y Tao, F Wang, Y Jiang, F L Sun and Z Mao

Cell Death and Differentiation 23: 1765-1777; Published online, 08 July 2016; doi:10.1038/cdd.2016.65

The miR-181d-regulated metalloproteinase Adamts1 enzymatically impairs adipogenesis via ECM remodeling  FREE

S-Z Chen, L-F Ning, X Xu, W-Y Jiang, C Xing, W-P Jia, X-L Chen, Q-Q Tang and H-Y Huang

Cell Death and Differentiation 23: 1778-1791; Published online, 22 July 2016; doi:10.1038/cdd.2016.66

Spermidine alleviates experimental autoimmune encephalomyelitis through inducing inhibitory macrophages  Open

Q Yang, C Zheng, J Cao, G Cao, P Shou, L Lin, T Velletri, M Jiang, Q Chen, Y Han, F Li, Y Wang, W Cao and Y Shi

Cell Death and Differentiation 23: 1850-1861; Published online, 22 July 2016; doi:10.1038/cdd.2016.71

Polycomb-mediated loss of microRNA let-7c determines inflammatory macrophage polarization via PAK1-dependent NF-κB pathway  FREE

W Zhang, H Liu, W Liu, Y Liu and J Xu

Cell Death and Differentiation 22: 287-297; Published online, 12 September 2014; doi:10.1038/cdd.2014.142

miR-361-regulated prohibitin inhibits mitochondrial fission and apoptosis and protects heart from ischemia injury  FREE

K Wang, C-Y Liu, X-J Zhang, C Feng, L-Y Zhou, Y Zhao and P-F Li

Cell Death and Differentiation 22: 1058-1068; Published online, 12 December 2014; doi:10.1038/cdd.2014.200

Suppression of epithelial–mesenchymal transition and apoptotic pathways by miR-294/302 family synergistically blocks let-7-induced silencing of self-renewal in embryonic stem cells  Open

W-T Guo, X-W Wang, Y-L Yan, Y-P Li, X Yin, Q Zhang, C Melton, A Shenoy, N A Reyes, S A Oakes, R Blelloch and Y Wang

Cell Death and Differentiation 22: 1158-1169; Published online, 12 December 2014; doi:10.1038/cdd.2014.205

Osteoblast-induced osteoclast apoptosis by fas ligand/FAS pathway is required for maintenance of bone mass  FREE

L Wang, S Liu, Y Zhao, D Liu, Y Liu, C Chen, S Karray, S Shi and Y Jin

Cell Death and Differentiation 22: 1654-1664; Published online, 06 March 2015; doi:10.1038/cdd.2015.14

Chaperone-like protein p32 regulates ULK1 stability and autophagy  FREE

H Jiao, G-Q Su, W Dong, L Zhang, W Xie, L-m Yao, P Chen, Z-X Wang, Y-C Liou and H You

Cell Death and Differentiation 22: 1812-1823; Published online, 23 April 2015; doi:10.1038/cdd.2015.34

RCAD/Ufl1, a Ufm1 E3 ligase, is essential for hematopoietic stem cell function and murine hematopoiesis  FREE

M Zhang, X Zhu, Y Zhang, Y Cai, J Chen, S Sivaprakasam, A Gurav, W Pi, L Makala, J Wu, B Pace, D Tuan-Lo, V Ganapathy, N Singh and H Li

Cell Death and Differentiation 22: 1922-1934; Published online, 08 May 2015; doi:10.1038/cdd.2015.51

PINK1 and Parkin cooperatively protect neurons against constitutively active TRP channel-induced retinal degeneration in Drosophila  Open

Z Huang, S Ren, Y Jiang and T Wang

Cell Death and Disease 7: e2179; Published online, 07 April 2016; doi:10.1038/cddis.2016.82

Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy  Open

Ying Gao, Yajun Liu, Liang Hong, Zuolong Yang, Xinran Cai, Xiaoyun Chen, Yuanyuan Fu, Yujie Lin, Weijie Wen, Sitong Li, Xingguo Liu, Heqing Huang, Andreas Vogt, Peiqing Liu, Xiao-Ming Yin and Min Li

Cell Death and Disease 7: e2330; Published online, 11 August 2016; doi:10.1038/cddis.2016.236

GRK6 regulates ROS response and maintains hematopoietic stem cell self-renewal  Open

Qiumin Le, Wenqing Yao, Yuejun Chen, Biao Yan, Cao Liu, Man Yuan, Yuqing Zhou and Lan Ma

Cell Death and Disease 7: e2478; Published online, 24 November 2016; doi:10.1038/cddis.2016.377

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