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Review Article
| Open AccessUncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiation
- Valentina C. Sladky
- & Andreas Villunger
-
Article |
Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer
- Soumyadip Das
- , Arun Pandian Chandrasekaran
- , Bharathi Suresh
- , Saba Haq
- , Jae-Hyeok Kang
- , Su-Jae Lee
- , Jaewon Kim
- , Jaesang Kim
- , Sanghyuk Lee
- , Hyongbum Henry Kim
- , Kye-Seong Kim
- & Suresh Ramakrishna
-
Correction |
Correction: Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation
- Plamena R. Angelova
- , Minee L. Choi
- , Alexey V. Berezhnov
- , Mathew H. Horrocks
- , Craig D. Hughes
- , Suman De
- , Margarida Rodrigues
- , Ratsuda Yapom
- , Daniel Little
- , Karamjit S. Dolt
- , Tilo Kunath
- , Michael J. Devine
- , Paul Gissen
- , Mikhail S. Shchepinov
- , Sergiy Sylantyev
- , Evgeny V. Pavlov
- , David Klenerman
- , Andrey Y. Abramov
- & Sonia Gandhi
-
Article |
Adipogenesis of skeletal muscle fibro/adipogenic progenitors is affected by the WNT5a/GSK3/β-catenin axis
- Alessio Reggio
- , Marco Rosina
- , Alessandro Palma
- , Andrea Cerquone Perpetuini
- , Lucia Lisa Petrilli
- , Cesare Gargioli
- , Claudia Fuoco
- , Elisa Micarelli
- , Giulio Giuliani
- , Mauro Cerretani
- , Alberto Bresciani
- , Francesca Sacco
- , Luisa Castagnoli
- & Gianni Cesareni
-
Article |
Monoglyceride lipase mediates tumor-suppressive effects by promoting degradation of X-linked inhibitor of apoptosis protein
- Renyan Liu
- , Xin Wang
- , Christopher Curtiss
- , M. Saeed Sheikh
- & Ying Huang
-
Article |
Chemical activation of SAT1 corrects diet-induced metabolic syndrome
- Francesca Castoldi
- , Mervi T. Hyvönen
- , Sylvère Durand
- , Fanny Aprahamian
- , Allan Sauvat
- , Shoaib A. Malik
- , Elisa Elena Baracco
- , Erika Vacchelli
- , Paule Opolon
- , Nicolas Signolle
- , Déborah Lefevre
- , Noelie Bossut
- , Tobias Eisenberg
- , Christopher Dammbrueck
- , Tobias Pendl
- , Margerie Kremer
- , Sylvie Lachkar
- , Claudia Einer
- , Bernhard Michalke
- , Hans Zischka
- , Frank Madeo
- , Tuomo A. Keinänen
- , Maria Chiara Maiuri
- , Federico Pietrocola
- & Guido Kroemer
-
Article |
Compensation between Wnt-driven tumorigenesis and cellular responses to ribosome biogenesis inhibition in the murine intestinal epithelium
- Aurélien Raveux
- , Aline Stedman
- , Sabrina Coqueran
- , Sandrine Vandormael-Pournin
- , Nick Owens
- , Béatrice Romagnolo
- & Michel Cohen-Tannoudji
-
Article |
CD9 induces cellular senescence and aggravates atherosclerotic plaque formation
- Jung Hee Cho
- , Eok-Cheon Kim
- , Youlim Son
- , Da-Woon Lee
- , Yong Seop Park
- , Joon Hyuk Choi
- , Kyung-Hyun Cho
- , Ki-Sun Kwon
- & Jae-Ryong Kim
-
Article |
JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction
- Luca Simula
- , Mauro Corrado
- , Benedetta Accordi
- , Anthea Di Rita
- , Francesca Nazio
- , Ylenia Antonucci
- , Arianna Di Daniele
- , Federico Caicci
- , Ignazio Caruana
- , Maria Eugenia Soriano
- , Martina Pigazzi
- , Franco Locatelli
- , Francesco Cecconi
- & Silvia Campello
-
Article |
Critical role of histone H3 lysine 27 demethylase Kdm6b in the homeostasis and function of medullary thymic epithelial cells
- Zhi Liu
- , Haohao Zhang
- , Yiming Hu
- , Dandan Liu
- , Lingling Li
- , Cuifeng Li
- , Qi Wang
- , Junhaohui Huo
- , Hanshao Liu
- , Ningxia Xie
- , Xingxu Huang
- , Yongzhong Liu
- , Charlie Degui Chen
- , Yufang Shi
- & Xiaoren Zhang
-
Article
| Open AccessInhibition of the autophagic protein ULK1 attenuates axonal degeneration in vitro and in vivo, enhances translation, and modulates splicing
- Björn Friedhelm Vahsen
- , Vinicius Toledo Ribas
- , Jonas Sundermeyer
- , Alexander Boecker
- , Vivian Dambeck
- , Christof Lenz
- , Orr Shomroni
- , Lucas Caldi Gomes
- , Lars Tatenhorst
- , Elisabeth Barski
- , Anna-Elisa Roser
- , Uwe Michel
- , Henning Urlaub
- , Gabriela Salinas
- , Mathias Bähr
- , Jan Christoph Koch
- & Paul Lingor
-
Article
| Open AccessTargeting triple-negative breast cancers with the Smac-mimetic birinapant
- Najoua Lalaoui
- , Delphine Merino
- , Goknur Giner
- , François Vaillant
- , Diep Chau
- , Lin Liu
- , Tobias Kratina
- , Bhupinder Pal
- , James R. Whittle
- , Nima Etemadi
- , Jean Berthelet
- , Julius Gräsel
- , Cathrine Hall
- , Matthew E. Ritchie
- , Matthias Ernst
- , Gordon K. Smyth
- , David L. Vaux
- , Jane E. Visvader
- , Geoffrey J. Lindeman
- & John Silke
-
Article
| Open AccessR-spondin2 signaling is required for oocyte-driven intercellular communication and follicular growth
- Marie-Cécile De Cian
- , Elodie P. Gregoire
- , Morgane Le Rolle
- , Simon Lachambre
- , Magali Mondin
- , Sheila Bell
- , Céline J. Guigon
- , Anne-Amandine Chassot
- & Marie-Christine Chaboissier
-
Article
| Open AccessThe apoptosome molecular timer synergises with XIAP to suppress apoptosis execution and contributes to prognosticating survival in colorectal cancer
- Gavin Fullstone
- , Tabea L. Bauer
- , Cristiano Guttà
- , Manuela Salvucci
- , Jochen H. M. Prehn
- & Markus Rehm
-
Article |
Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation
- Plamena R. Angelova
- , Minee L. Choi
- , Alexey V. Berezhnov
- , Mathew H. Horrocks
- , Craig D. Hughes
- , Suman De
- , Margarida Rodrigues
- , Ratsuda Yapom
- , Daniel Little
- , Karamjit S. Dolt
- , Tilo Kunath
- , Michael J. Devine
- , Paul Gissen
- , Mikhail S. Shchepinov
- , Sergiy Sylantyev
- , Evgeny V. Pavlov
- , David Klenerman
- , Andrey Y. Abramov
- & Sonia Gandhi
-
Article
| Open AccessHSPA12A attenuates lipopolysaccharide-induced liver injury through inhibiting caspase-11-mediated hepatocyte pyroptosis via PGC-1α-dependent acyloxyacyl hydrolase expression
- Jiali Liu
- , Shuya Du
- , Qiuyue Kong
- , Xiaojin Zhang
- , Surong Jiang
- , Xiaofei Cao
- , Yuehua Li
- , Chuanfu Li
- , Huaqun Chen
- , Zhengnian Ding
- & Li Liu
-
Article |
Hippo kinases MST1 and MST2 control the differentiation of the epididymal initial segment via the MEK-ERK pathway
- Chenling Meng
- , Geng Tian
- , Chunhua Xu
- , Xiaofeng Li
- , Yu Zhang
- , Yang Wang
- , Jinzhong Qin
- , Ellis Kin Lam Fok
- , Barry T. Hinton
- , Kingston King-lun Mak
- , Winnie Waichi Shum
- , Wai-Yee Chan
- & Yin Xia
-
Article
| Open AccessThe deubiquitylase USP2 maintains ErbB2 abundance via counteracting endocytic degradation and represents a therapeutic target in ErbB2-positive breast cancer
- Jinrui Zhang
- , Shuyan Liu
- , Qiong Li
- , Yulin Shi
- , Yueguang Wu
- , Fang Liu
- , Shanshan Wang
- , Mohamed Y. Zaky
- , Waleed Yousuf
- , Qianhui Sun
- , Dong Guo
- , Taishu Wang
- , Yingqiu Zhang
- , Yang Wang
- , Man Li
- & Han Liu
-
Article |
Deficiency in fibroblast PPARβ/δ reduces nonmelanoma skin cancers in mice
- Mark Wei Yi Tan
- , Ming Keat Sng
- , Hong Sheng Cheng
- , Zun Siong Low
- , Benjamin Jia Juin Leong
- , Damien Chua
- , Eddie Han Pin Tan
- , Jeremy Soon Kiat Chan
- , Yun Sheng Yip
- , Yin Hao Lee
- , Mintu Pal
- , Xiaomeng Wang
- , Walter Wahli
- & Nguan Soon Tan
-
Article
| Open AccessThe SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L)
- Jamie Z. Roberts
- , Caitriona Holohan
- , Tamas Sessler
- , Jennifer Fox
- , Nyree Crawford
- , Joel S. Riley
- , Hajrah Khawaja
- , Joanna Majkut
- , Emma Evergren
- , Luke M. Humphreys
- , Jennifer Ferris
- , Catherine Higgins
- , Margarita Espona-Fiedler
- , Paul Moynagh
- , Simon S. McDade
- & Daniel B. Longley
-
Correction |
Correction: The lipogenic LXR-SREBF1 signaling pathway controls cancer cell DNA repair and apoptosis and is a vulnerable point of malignant tumors for cancer therapy
- Bo Yang
- , Bin Zhang
- , Zhifei Cao
- , Xingdong Xu
- , Zihe Huo
- , Pan Zhang
- , Shufen Xiang
- , Zhe Zhao
- , Chunping Lv
- , Mei Meng
- , Gaochuan Zhang
- , Liang Dong
- , Shucheng Shi
- , Lan Yang
- & Quansheng Zhou
-
Comment |
The scent of death: a metabolic goodbye signal emitted by dying cells
- Guido Kroemer
- & Federico Pietrocola
-
Editorial |
Loss of the deubiquitinase OTULIN promotes hepatocellular carcinoma (HCC) in an mTOR-dependent manner
- Antonio Marzio
- & Michele Pagano
-
Article
| Open AccessOTULIN protects the liver against cell death, inflammation, fibrosis, and cancer
- Rune Busk Damgaard
- , Helen E. Jolin
- , Michael E. D. Allison
- , Susan E. Davies
- , Hannah L. Titheradge
- , Andrew N. J. McKenzie
- & David Komander
-
Article
| Open AccessHPV-mediated nuclear export of HP1γ drives cervical tumorigenesis by downregulation of p53
- Sang Ah Yi
- , Dong Hoon Lee
- , Go Woon Kim
- , Hyun-Wook Ryu
- , Jong Woo Park
- , Jaecheol Lee
- , Jihoon Han
- , Jee Hun Park
- , Hwamok Oh
- , Jieun Lee
- , Junjeong Choi
- , Hyun-Soo Kim
- , Hyeok Gu Kang
- , Da-Hyun Kim
- , Kyung-Hee Chun
- , Jueng Soo You
- , Jeung-Whan Han
- & So Hee Kwon
-
Correction |
Correction: Cumulative inactivation of Nell-1 in Wnt1 expressing cell lineages results in craniofacial skeletal hypoplasia and postnatal hydrocephalus
- Xiaoyan Chen
- , Huiming Wang
- , Mengliu Yu
- , Jong Kil Kim
- , Huichuan Qi
- , Pin Ha
- , Wenlu Jiang
- , Eric Chen
- , Xiangyou Luo
- , Ryan Brent Needle
- , Lloyd Baik
- , Cathryn Yang
- , Jiejun Shi
- , Jin Hee Kwak
- , Kang Ting
- , Xinli Zhang
- & Chia Soo
-
Editorial |
COVID-19 infection: the perspectives on immune responses
- Yufang Shi
- , Ying Wang
- , Changshun Shao
- , Jianan Huang
- , Jianhe Gan
- , Xiaoping Huang
- , Enrico Bucci
- , Mauro Piacentini
- , Giuseppe Ippolito
- & Gerry Melino
-
Article |
Drp1 modulates mitochondrial stress responses to mitotic arrest
- Aida Peña-Blanco
- , Manuel D. Haschka
- , Andreas Jenner
- , Theresia Zuleger
- , Tassula Proikas-Cezanne
- , Andreas Villunger
- & Ana J. García-Sáez
-
Article |
Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia/reperfusion-induced acute lung injury
- Yingchuan Li
- , Yongmei Cao
- , Jian Xiao
- , Jiawei Shang
- , Qin Tan
- , Feng Ping
- , Weifeng Huang
- , Fang Wu
- , Haijun Zhang
- & Xiaoping Zhang
-
Meeting Report |
Paradise revealed III: why so many ways to die? Apoptosis, necroptosis, pyroptosis, and beyond
- Marcelo Pires Amaral
- , Laura Migliari Branco
- , Andreas Strasser
- , Vishva M. Dixit
- & Karina Ramalho Bortoluci
-
Article |
RIPK3 collaborates with GSDMD to drive tissue injury in lethal polymicrobial sepsis
- Hui Chen
- , Yinshuang Li
- , Jianfeng Wu
- , Guoping Li
- , Xuan Tao
- , Kunmei Lai
- , Ying Yuan
- , Xiaohong Zhang
- , Zhenhuan Zou
- & Yanfang Xu
-
Article |
Angiotensin-(1–9) prevents cardiomyocyte hypertrophy by controlling mitochondrial dynamics via miR-129-3p/PKIA pathway
- Cristian Sotomayor-Flores
- , Pablo Rivera-Mejías
- , César Vásquez-Trincado
- , Camila López-Crisosto
- , Pablo E. Morales
- , Christian Pennanen
- , Iva Polakovicova
- , Víctor Aliaga-Tobar
- , Lorena García
- , Juan Carlos Roa
- , Beverly A. Rothermel
- , Vinicius Maracaja-Coutinho
- , Hung Ho-Xuan
- , Gunter Meister
- , Mario Chiong
- , María Paz Ocaranza
- , Alejandro H. Corvalán
- , Valentina Parra
- & Sergio Lavandero
-
Correction
| Open AccessCorrection: Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload
- Nicoletta Plotegher
- , Dany Perocheau
- , Ruggero Ferrazza
- , Giulia Massaro
- , Gauri Bhosale
- , Federico Zambon
- , Ahad A. Rahim
- , Graziano Guella
- , Simon N. Waddington
- , Gyorgy Szabadkai
- & Michael R. Duchen
-
Article |
Fenretinide induces a new form of dynamin-dependent cell death in pediatric sarcoma
- Eva Brack
- , Marco Wachtel
- , Anja Wolf
- , Andres Kaech
- , Urs Ziegler
- & Beat W. Schäfer
-
Article |
The lipogenic LXR-SREBF1 signaling pathway controls cancer cell DNA repair and apoptosis and is a vulnerable point of malignant tumors for cancer therapy
- Bo Yang
- , Bin Zhang
- , Zhifei Cao
- , Xingdong Xu
- , Zihe Huo
- , Pan Zhang
- , Shufen Xiang
- , Zhe Zhao
- , Chunping Lv
- , Mei Meng
- , Gaochuan Zhang
- , Liang Dong
- , Shucheng Shi
- , Lan Yang
- & Quansheng Zhou
-
Article |
BRUCE preserves genomic stability in the male germline of mice
- Lixiao Che
- , Kris G. Alavattam
- , Peter J. Stambrook
- , Satoshi H. Namekawa
- & Chunying Du
-
Article |
Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling
- Naijin Zhang
- , Ying Zhang
- , Hao Qian
- , Shaojun Wu
- , Liu Cao
- & Yingxian Sun
-
Article
| Open Access53BP1 loss rescues embryonic lethality but not genomic instability of BRCA1 total knockout mice
- Jiyuan Chen
- , Peng Li
- , Licun Song
- , Long Bai
- , Michael S. Y. Huen
- , Yidan Liu
- & Lin-Yu Lu
-
Article |
Deleting key autophagy elongation proteins induces acquirement of tumor-associated phenotypes via ISG15
- EunBin Kong
- , Hag Dong Kim
- & Joon Kim
-
Article |
Oocyte competence is maintained by m6A methyltransferase KIAA1429-mediated RNA metabolism during mouse follicular development
- Yue Hu
- , Zhangyi Ouyang
- , Xuesong Sui
- , Meijie Qi
- , Mingrui Li
- , Yuanlin He
- , Yumeng Cao
- , Qiqi Cao
- , Qianneng Lu
- , Shuai Zhou
- , Lu Liu
- , Li Liu
- , Bin Shen
- , Wenjie Shu
- & Ran Huo
-
Article
| Open AccessMARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex
- Tirta Mario Djajawi
- , Lei Liu
- , Jia-nan Gong
- , Allan Shuai Huang
- , Ming-jie Luo
- , Zhen Xu
- , Toru Okamoto
- , Melissa J. Call
- , David C. S. Huang
- & Mark F. van Delft
-
Article
| Open AccessConvergence of pathway analysis and pattern recognition predicts sensitization to latest generation TRAIL therapeutics by IAP antagonism
- Vesna Vetma
- , Cristiano Guttà
- , Nathalie Peters
- , Christian Praetorius
- , Meike Hutt
- , Oliver Seifert
- , Friedegund Meier
- , Roland Kontermann
- , Dagmar Kulms
- & Markus Rehm
-
Article
| Open AccessSquamous differentiation requires G2/mitosis slippage to avoid apoptosis
- Natalia Sanz-Gómez
- , Isabel de Pedro
- , Beatriz Ortigosa
- , David Santamaría
- , Marcos Malumbres
- , Guillermo de Cárcer
- & Alberto Gandarillas
-
Article |
Rab5a activates IRS1 to coordinate IGF-AKT-mTOR signaling and myoblast differentiation during muscle regeneration
- Xiao Xia Cong
- , Xiu Kui Gao
- , Xi Sheng Rao
- , Jie Wen
- , Xiao Ceng Liu
- , Yin Pu Shi
- , Min Yi He
- , Wei Liang Shen
- , Yue Shen
- , Hongwei Ouyang
- , Ping Hu
- , Boon Chuan Low
- , Zhuo Xian Meng
- , Yue Hai Ke
- , Ming Zhu Zheng
- , Lin Rong Lu
- , Yong Heng Liang
- , Li Ling Zheng
- & Yi Ting Zhou
-
Article
| Open AccessDrp1 overexpression induces desmin disassembling and drives kinesin-1 activation promoting mitochondrial trafficking in skeletal muscle
- Matteo Giovarelli
- , Silvia Zecchini
- , Emanuele Martini
- , Massimiliano Garrè
- , Sara Barozzi
- , Michela Ripolone
- , Laura Napoli
- , Marco Coazzoli
- , Chiara Vantaggiato
- , Paulina Roux-Biejat
- , Davide Cervia
- , Claudia Moscheni
- , Cristiana Perrotta
- , Dario Parazzoli
- , Emilio Clementi
- & Clara De Palma
-
Article
| Open AccessCrenigacestat, a selective NOTCH1 inhibitor, reduces intrahepatic cholangiocarcinoma progression by blocking VEGFA/DLL4/MMP13 axis
- Serena Mancarella
- , Grazia Serino
- , Francesco Dituri
- , Antonio Cigliano
- , Silvia Ribback
- , Jingxiao Wang
- , Xin Chen
- , Diego F. Calvisi
- & Gianluigi Giannelli
-
Article
| Open AccessSpatio-temporal characterization of the antiviral activity of the XRN1-DCP1/2 aggregation against cytoplasmic RNA viruses to prevent cell death
- Chen Seng Ng
- , Dacquin M. Kasumba
- , Takashi Fujita
- & Honglin Luo
-
-
Article |
Mutant GTF2I induces cell transformation and metabolic alterations in thymic epithelial cells
- In-Kyu Kim
- , Guanhua Rao
- , Xiaoliang Zhao
- , Ruzong Fan
- , Maria Laura Avantaggiati
- , Yisong Wang
- , Yu-Wen Zhang
- & Giuseppe Giaccone
