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Exacerbation of IgA nephropathy following G-CSF administration for PBSC collection: suggestions for better donor screening

Bone Marrow Transplantation volume 51, pages 286–287 (2016)Cite this article

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The incidence of serious adverse reactions associated with donation of haematopoietic stem cells by unrelated donors was recently reviewed and reported to be low by Pulsipher et al.1 Macroscopic haematuria was however reported on three occasions following PBSC donation despite strict donor selection criteria and a thorough medical workup to establish the medical suitability of a given donor. Recently we have encountered three cases of haematuria in stem cell donors, two at the Anthony Nolan unrelated donor registry and one case from the Ulster Hospital renal unit, highlighting that serious underlying medical conditions may go unnoticed despite rigorous assessment.

A 28-year-old Caucasian male listed on the Anthony Nolan donor register was selected as an HLA-matched unrelated donor for a patient in need of a haematopoietic stem cell transplant. He had declared no serious medical conditions at earlier stages of donor procurement, and was approved to continue to medical workup. At workup, he reported an episode of self-limiting visible haematuria 1 year previously. A renal ultrasound at the time was normal, and he was diagnosed with an assumed episode of haemorrhagic cystitis, probably due to a urinary tract infection. He had no further episodes of haematuria following this. He was physically well with a normal examination on the day of workup.

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Authors and Affiliations

  1. Department of Renal Medicine, King’s College Hospital, London, UK

    J B L Lee & C C Sharpe

  2. Anthony Nolan, London, UK

    A Billen, R N Lown, C F Craddock & B E Shaw

  3. UCL Cancer Institute, London, UK

    A Billen, R N Lown & B E Shaw

  4. Royal Marsden NHS Foundation Trust, London, UK

    M N Potter & B E Shaw

  5. Centre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham, UK

    C F Craddock

  6. Department of Haematology, King’s College Hospital, London, UK

    H de Lavallade

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  1. J B L Lee
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  2. A Billen
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  3. R N Lown
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  7. B E Shaw
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Correspondence to J B L Lee.

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Lee, J., Billen, A., Lown, R. et al. Exacerbation of IgA nephropathy following G-CSF administration for PBSC collection: suggestions for better donor screening. Bone Marrow Transplant 51, 286–287 (2016). https://doi.org/10.1038/bmt.2015.224

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