Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Special Report
  • Published:

Related hematopoietic cell donor care: is there a role for unrelated donor registries?

Bone Marrow Transplantation volume 50, pages 637–641 (2015)Cite this article

Subjects

Abstract

In almost half of allogeneic hematopoietic progenitor cell (HPC) transplants, a related donor (RD) is used, yet a lack of standardized guidelines means that their care is heterogeneous. Changes to regulatory standards aim to improve uniformity, but adherence to these regulations can prove logistically difficult for the transplant centers (TCs) managing RDs. Discussion has ensued around possible alternative models of related donor care and a session at the European Society for Blood and Marrow Transplantation (EBMT) annual meeting in 2013 debated the question of whether a role exists for unrelated donor registries in the management of ‘related’ donors. In this overview, we discuss the issues raised at this debate and the pros and cons of donor registry involvement in various aspects of RD management. By examining existing models of related donor care that have been adopted by members of the World Marrow Donor Association (WMDA), we look for ways to enhance and homogenize RD care, while also enabling transplant centers to meet standards required for mandatory accreditation.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. WMDA. International Standards for Unrelated Hematopoietic Progenitor Cell Donor Registries standards W. International Standards for Unrelated Hematopoietic Progenitor Cell Donor Registries. Available at http://www.worldmarrow.org/fileadmin/Committees/STDC/20140101-STDC-WMDA_Standards.pdf. Accessed 9 October 2013.

  2. Clare S, Mank A, Stone R, Davies M, Potting C, Apperley JF et al. Management of related donor care: a European survey. Bone Marrow Transplant 2010; 45: 97–101.

    Article  CAS  Google Scholar 

  3. O'Donnell PV, Pedersen TL, Confer DL, Rizzo JD, Pulsipher MA, Stroncek D et al. Practice patterns for evaluation, consent, and care of related donors and recipients at hematopoietic cell transplantation centers in the United States. Blood 2010; 115: 5097–5101.

    Article  CAS  Google Scholar 

  4. van Walraven SM, Nicoloso-de Faveri G, Axdorph-Nygell UA, Douglas KW, Jones DA, Lee SJ et al. Family donor care management: principles and recommendations. Bone Marrow Transplant 2010; 45: 1269–1273.

    Article  CAS  Google Scholar 

  5. Coluccia P, Crovetti G, Del Fante C, Dallavalle FM, Laszlo D, Ferremi P et al. Screening of related donors and peripheral blood stem cell collection practices at different Italian apheresis centres. Blood Transfus 2012; 10: 440–447.

    PubMed  PubMed Central  Google Scholar 

  6. Joint Accreditation Committee-ISCT & EBMT. International standards for cellular therapy product collection processing and adminstration. 5th edition. Available at http://www.jacie.org. Accessed 9 October 2013.

  7. Halter JP, van Walraven SM, Worel N, Bengtsson M, Hagglund H, Nicoloso de Faveri G et al. Allogeneic hematopoietic stem cell donation-standardized assessment of donor outcome data: a consensus statement from the Worldwide Network for Blood and Marrow Transplantation (WBMT). Bone Marrow Transplant 2013; 48: 220–225.

    Article  CAS  Google Scholar 

  8. Halter J, Kodera Y, Ispizua AU, Greinix HT, Schmitz N, Favre G et al. Severe events in donors after allogeneic hematopoietic stem cell donation. Haematologica 2009; 94: 94–101.

    Article  Google Scholar 

  9. Horowitz MM, Confer DL . Evaluation of hematopoietic stem cell donors. Hematology / the Education Program of the American Society of Hematology. Am Soc Hematol Educ Program 2005; 1: 469–475.

    Article  Google Scholar 

  10. Wiersum-Osselton JC, van Walraven SM, Bank I, Lenselink AM, Fibbe WE, van der Bom JG et al. Clinical outcomes after peripheral blood stem cell donation by related donors: a Dutch single-center cohort study. Transfusion 2013; 53: 96–103.

    Article  Google Scholar 

  11. Kodera Y, Yamamoto K, Harada M, Morishima Y, Dohy H, Asano S et al. PBSC collection from family donors in Japan: a prospective survey. Bone Marrow Transplant 2013; 49: 195–200.

    Article  Google Scholar 

  12. Switzer GE, Dew MA, Magistro CA, Goycoolea JM, Twillman RK, Alter C et al. The effects of bereavement on adult sibling bone marrow donors' psychological well-being and reactions to donation. Bone Marrow Transplant 1998; 21: 181–188.

    Article  CAS  Google Scholar 

  13. Foster RS . Conflicts of interest: recognition, disclosure, and management. J Am Coll Surg 2003; 196: 505–517.

    Article  Google Scholar 

  14. WHO guiding principles on human cell, tissue and organ transplantation. Available at http://www.who.int/transplantation/Guiding_PrinciplesTransplantation_WHA63.22en.pdf. Accessed 9 October 2013.

  15. Sacchi N, Costeas P, Hartwell L, Hurley CK, Raffoux C, Rosenmayr A et al. Haematopoietic stem cell donor registries: World Marrow Donor Association recommendations for evaluation of donor health. Bone Marrow Transplant 2008; 42: 9–14.

    Article  CAS  Google Scholar 

  16. van Walraven SM, Straathof LM, Switzer GE, Lankester A, Korthof ET, Brand A et al. Immediate and long-term somatic effects, and health-related quality of life of BM donation during early childhood. A single-center report in 210 pediatric donors. Bone Marrow Transplant 2013; 48: 40–45.

    Article  CAS  Google Scholar 

  17. Pulsipher MA, Nagler A, Iannone R, Nelson RM . Weighing the risks of G-CSF administration, leukopheresis, and standard marrow harvest: ethical and safety considerations for normal pediatric hematopoietic cell donors. Pediatr Blood Cancer 2006; 46: 422–433.

    Article  Google Scholar 

  18. Pulsipher MA . A donor's a person, no matter how small. Blood 2012; 119: 2705–2706.

    Article  CAS  Google Scholar 

  19. Styczynski J, Balduzzi A, Gil L, Labopin M, Hamladji RM, Marktel S et al. Risk of complications during hematopoietic stem cell collection in pediatric sibling donors: a prospective European Group for Blood and Marrow Transplantation Pediatric Diseases Working Party study. Blood 2012; 119: 2935–2942.

    Article  CAS  Google Scholar 

  20. Simmons RG, Schimmel M, Butterworth VA . The self-image of unrelated bone marrow donors. J Health Soc Behav 1993; 34: 285–301.

    Article  CAS  Google Scholar 

  21. van Walraven SM, Ball LM, Koopman HM, Switzer GE, Ropes-de Jong CM, de Jong A et al. Managing a dual role-experiences and coping strategies of parents donating haploidentical G-CSF mobilized peripheral blood stem cells to their children. Psychooncology 2012; 21: 168–175.

    Article  CAS  Google Scholar 

  22. Taghavi R, Mahdavi R, Toufani H . The psychological effects of kidney donation on living kidney donors (related and unrelated). Transplant Proc 2001; 33: 2636–2637.

    Article  CAS  Google Scholar 

  23. Ethics Committee of the Transplantation S. The consensus statement of the Amsterdam Forum on the Care of the Live Kidney Donor. Transplantation 2004; 78: 491–492.

    Google Scholar 

  24. WHO. Notify Report: Exploring vigilance notification for organs tissues and cells 2011. Available at http://www.notifylibrary.org/sites/default/files/BOOK%20NOTIFY.pdf.

  25. Shaw BE, Confer DL, Hwang WY, Pamphilon DH, Pulsipher MA . Concerns about the use of biosimilar granulocyte colony-stimulating factors for the mobilization of stem cells in normal donors: position of the World Marrow Donor Association. Haematologica 2011; 96: 942–947.

    Article  Google Scholar 

  26. Pentz RD, Alderfer MA, Pelletier W, Stegenga K, Haight AE, Hendershot KA et al. Unmet needs of siblings of pediatric stem cell transplant recipients. Pediatrics 2014; 133: e1156–e1162.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Anthony Nolan Research Institute, UCL Cancer Centre, London, UK

    C Anthias & B E Shaw

  2. Europdonor Foundation, Leiden, The Netherlands

    S M van Walraven & M Fechter

  3. Department of Clinical Immunology, Aarhus University Hospital, Skejby, Denmark

    B S Sørensen

  4. Swiss Blood stem cells, Bern, Switzerland

    G N de Faveri

  5. Department of Haematology, Bristol Royal Hospital for Children, Bristol, UK

    J Cornish

  6. Division of Hematology and Bone Marrow Transplantation, IRCCS San Martino, Genova, Italy

    A Bacigalupo

  7. Zentrales Knochenmarkspender-Register für Deutschland, Ulm, Germany

    C Müller

  8. Deutsches Register für Stammzelltransplantationen (DRST), Ulm, Germany

    C Müller

  9. National Marrow Donor Program, Minneapolis, MN, USA

    M Boo

  10. Department of Haemato-oncology, The Royal Marsden Hospital Downs Rd, Sutton, UK

    B E Shaw

Authors
  1. C Anthias
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S M van Walraven
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B S Sørensen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G N de Faveri
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M Fechter
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J Cornish
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. A Bacigalupo
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. C Müller
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. M Boo
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. B E Shaw
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to C Anthias.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Anthias, C., van Walraven, S., Sørensen, B. et al. Related hematopoietic cell donor care: is there a role for unrelated donor registries?. Bone Marrow Transplant 50, 637–641 (2015). https://doi.org/10.1038/bmt.2015.15

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/bmt.2015.15

This article is cited by

Search

Advanced search

Quick links