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Fecal microbiota transplant after hematopoietic SCT: report of a successful case

Bone Marrow Transplantation volume 50, page 145 (2015)Cite this article

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Fecal microbiota transplants1 are being commonly used for treating patients with Clostridium difficile infections. Patients who receive BM transplantation experience severe immune suppression not only because of the drugs used in the conditioning and immunosuppression therapies, but also because of the procedure itself. Owing to the concerns associated with microbiota transplant in this population of patients, very few case reports have been published so far.2

We recently treated a 60-year-old woman with Philadelphia-positive acute lymphoblastic leukemia (ALL). She received chemotherapy and achieved full remission. Four months after the initial diagnosis, an allogeneic transplantation from an unrelated donor was performed using fludarabine and BU in the conditioning regimen. She received the immunosuppressive agents, tacrolimus and MTX.

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References

  1. Kelly CR, Ihunnah C, Fischer M, Khoruts A, Surawicz C, Afzali A et al. Fecal microbiota transplant for treatment of Clostridium difficile infection in immunocompromised patients. Am J Gastroenterol 2014; 109: 1065–1071.

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Authors and Affiliations

  1. Hematology and Bone Marrow Transplantation, Hospital Israelita Albert Einstein, São Paulo, Brazil

    C G de Castro Jr

  2. Endoscopy Department, Hospital Israelita Albert Einstein, São Paulo, Brazil

    A J Ganc

  3. Gastroenterology and Endoscopy Departments, Hospital Israelita Albert Einstein, São Paulo, Brazil

    R L Ganc

  4. Santa Marcelina Hospital, São Paulo, Brazil

    M S Petrolli

  5. Hematology and Bone Marrow Transplantation, Hospital Israelita Albert Einstein, São Paulo, Brazil

    N Hamerschlack

Authors
  1. C G de Castro Jr
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  2. A J Ganc
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  3. R L Ganc
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  4. M S Petrolli
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  5. N Hamerschlack
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Corresponding author

Correspondence to C G de Castro Jr.

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de Castro, C., Ganc, A., Ganc, R. et al. Fecal microbiota transplant after hematopoietic SCT: report of a successful case. Bone Marrow Transplant 50, 145 (2015). https://doi.org/10.1038/bmt.2014.212

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