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Autologous cord blood transplantation in a child with stage 4 neuroblastoma

Bone Marrow Transplantation volume 48, pages 317–318 (2013)Cite this article

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A 2-year, 6-month-old girl presented with a large abdominal mass. A computed tomography scan revealed a tumor ∼12 cm in diameter arising from the left adrenal gland. A complete blood count showed a WBC count of 9.39 × 109/L, hemoglobin 9.1 g/dL, and platelets 431 × 109/L. She had an elevated urinary vanillylmandelic acid level of 9.94 mg/day, and a serum lactate dehydrogenase level of 1968 IU/L. A BM biopsy was performed, and the pathological examination revealed invasion of neuroblastoma cells that were positive for neuron-specific enolase and synaptophysin. A technetium-99 bone scan demonstrated multiple bony metastases.

A diagnosis of stage 4 neuroblastoma was made, and she began preoperative chemotherapy, as suggested by the N2002-HR2 regimen of the Taiwan Pediatric Oncology Group. The induction chemotherapy included three cycles of CDV (CY, vincristine and adriamycin) and two cycles of CiE (etoposide and cisplatin). Subsequently, the residual tumor, which was about 4 cm in diameter, was nearly totally resected. According to the protocol, she received an additional cycle of CDV after the operation.

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Acknowledgements

This study was supported partially by grants from the China Medical University Hospital (DMR-101-043) and Chung Shan Medical University Hospital (CSH-2012-A-004).

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Authors and Affiliations

  1. Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan

    K-H Wu, S-M Wang, T Weng & C-T Peng

  2. School of Chinese Medicine, China Medical University, Taichung, Taiwan

    K-H Wu & C-T Peng

  3. Department of Pediatrics, Buddhist Tzu-Chi General Hospital, Taichung Branch, Taichung, Taiwan

    H-P Wu

  4. Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan

    C-T Peng

  5. Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan

    Y-H Chao

  6. School of Medicine, Chung Shan Medical University, Taichung, Taiwan

    Y-H Chao

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  1. K-H Wu
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Correspondence to Y-H Chao.

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Wu, KH., Wang, SM., Wu, HP. et al. Autologous cord blood transplantation in a child with stage 4 neuroblastoma. Bone Marrow Transplant 48, 317–318 (2013). https://doi.org/10.1038/bmt.2012.146

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