Abstract
Infertility is a major late effect in patients receiving haematopoietic stem cell transplantation (HSCT). The aim of this study was to determine the proportion of patients having fertility impairment after allogeneic HSCT in childhood/adolescence and to identify the potential risk factors. Treatment and fertility data of paediatric patients with malignant and non-malignant diseases treated with allogeneic HSCT between 2000 and 2005 were collected from seven European centres. Data were obtained for 138 female and 206 male patients after a median follow-up of 6 years (range 3–12). The patients’ median age was 13 years (range 4–28) at the time of HSCT and 19 (range 12–35) years at the time of the enquiry. Seven children were born to the overall group, all at term and healthy. Fertility impairment was suspected in 69% males and 83% females. Start of treatment at age ⩾13 years was a risk factor in females (odds ratio (OR) 4.7; 95% confidence interval (CI), 1.5 to 14.9), whereas pre-pubertal therapy was a risk factor in males (OR 0.4; 95% CI, 0.2 to 0.8). The major treatment-related risk factors were BU in females (OR 47.4; 95% CI, 5.4 to 418.1) and TBI in males (OR 7.7; 95% CI, 2.3 to 25.4). In light of the significant proportion of HSCT patients reviewed with impaired fertility, fertility conservation procedures should be considered for all patients undergoing HSCT, particularly those receiving TBI or BU-based preparative regimens.
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References
European Group for Blood and Marrow Transplantation. Statistical Summary of EBMT Database, March 2005. Available at: http://www.ebmt.org/4Registry/registry5.html (accessed May 2008).
Mertens AC, Ramsay NK, Kouris S, Neglia JP . Patterns of gonadal dysfunction following bone marrow transplantation. Bone Marrow Transplant 1998; 22: 345–350.
Salooja N, Szydlo RM, Socie G, Rio B, Chatterjee R, Ljungman P et al. Pregnancy outcomes after peripheral blood or bone marrow transplantation: a retrospective survey. Lancet 2001; 358: 271–276.
Bines J, Oleske DM, Cobleigh MA . Ovarian function in premenopausal women treated with adjuvant chemotherapy for breast cancer. J Clin Oncol 1996; 14: 1718–1729.
Lutchman Singh K, Davies M, Chatterjee R . Fertility in female cancer survivors: pathophysiology, preservation and the role of ovarian reserve testing. Hum Reprod Update 2005; 11: 69–89.
Rowley MJ, Leach DR, Warner GA, Heller CG . Effect of graded doses of ionizing radiation on the human testis. Radiat Res 1974; 59: 665–678.
Wallace WH, Shalet SM, Crowne EC, Morris-Jones PH, Gattamaneni HR . Ovarian failure following abdominal irradiation in childhood: natural history and prognosis. Clin Oncol (R Coll Radiol) 1989; 1: 75–79.
Meistrich ML, Vassilopoulou-Sellin R, Lipshultz LI . Gonadal dysfunction. In: de Vita VT, Hellmann S, Rosenberg R (eds). Cancer Principles and Practice of Oncology, 6th edn Lippincott, Philadelphia, 2001, pp 2923–2939.
Sherins RJ . Gonadal dysfunction. In: de Vita VT, Hellmann S, Rosenberg R (eds). Cancer Principles and Practice of Oncology, 4th edn Lippincott, Philadelphia, 1993. pp 2395–2404.
Howell S, Shalet S . Gonadal damage from chemotherapy and radiotherapy. Endocrinol Metab Clin North Am 1998; 27: 927–943.
Herrmann T . Radiation reactions in the gonads: importance in patient counselling. Strahlenther Onkol 1997; 173: 493–501.
Howell SJ, Shalet SM . Fertility preservation and management of gonadal failure associated with lymphoma therapy. Curr Oncol Rep 2002; 4: 443–452.
Meirow D, Nugent D . The effects of radiotherapy and chemotherapy on female reproduction. Hum Reprod Update 2001; 7: 535–543.
Chapman RM, Sutcliffe SB, Malpas JS . Cytotoxic-induced ovarian failure in women with Hodgkin's disease. I. Hormone function. JAMA 1979; 242: 1877–1881.
Koyama H, Wada T, Nishizawa Y, Iwanaga T, Aoki Y . Cyclophosphamide-induced ovarian failure and its therapeutic significance in patients with breast cancer. Cancer 1977; 39: 1403–1409.
Warne GL, Fairley KF, Hobbs JB, Martin FI . Cyclophosphamide-induced ovarian failure. N Engl J Med 1973; 289: 1159–1162.
Gradishar WJ, Schilsky RL . Ovarian function following radiation and chemotherapy for cancer. Semin Oncol 1989; 16: 425–436.
Schreiber G, Hipler U . The significance of microorchidism for fertility and endocrine testicular function. Hautarzt 2000; 51: 833–837 (in German).
Mertens AC, Ramsay NK, Kouris S, Neglia JP . Patterns of gonadal dysfunction following bone marrow transplantation. Bone Marrow Transplant 1998; 22: 345–350.
Rosendahl M, Andersen CY, la Cour Freiesleben N, Juul A, Løssl K, Andersen AN . Dynamics and mechanisms of chemotherapy-induced ovarian follicular depletion in women of fertile age. Fertil Steril 2010; 94: 156–166.
Rendtorff R, Hohmann C, Reinmuth S, Müller A, Dittrich R, Beyer M et al. Hormone and sperm analyses after chemo- and radiotherapy in childhood and adolescence. Klin Padiatr 2010; 222: 145–149.
Thibaud E, Rodriguez-Macias K, Trivin C, Espérou H, Michon J, Brauner R . Ovarian function after bone marrow transplantation during childhood. Bone Marrow Transplant 1998; 21: 287–290.
Matsumoto M, Shinohara O, Ishiguro H, Shimizu T, Hattori K, Ichikawa M et al. Ovarian function after bone marrow transplantation performed before menarche. Arch Dis Child 1999; 80: 452–454.
Rovo A, van Lint MT, Aljurf M, Salooja N, Sucak G, Hunter A et al. Spermatogenesis recovery in male survivors after HSCT: evidence for graft-versus-testis effect. Paper presented at 36th Annual Meeting of the European Group for Blood and Marrow Transplantation; 21–24 March 2010; Vienna, Austria, 2010.
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Borgmann-Staudt, A., Rendtorff, R., Reinmuth, S. et al. Fertility after allogeneic haematopoietic stem cell transplantation in childhood and adolescence. Bone Marrow Transplant 47, 271–276 (2012). https://doi.org/10.1038/bmt.2011.78
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DOI: https://doi.org/10.1038/bmt.2011.78
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