Bone Marrow Transplantation

FIGURE 3

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Differential chemokine expression in chronic GVHD of the conjunctiva

H Westekemper, S Meller, S Citak, C Schulte, K-P Steuhl, B Homey and D Meller

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Figure 3.

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Immunohistochemistry of the chemokine (C-X-C motif) receptor (CXCR) 3, chemokine (C-X-C motif) ligand (CXCL) 12 (SDF-1α and CXCR4 expression in the conjunctival tissue (magnification × 200). (a, c and e) Controls; (b, d and f) GVHD patients. (a and b) CXCR3; (c and d) CXCL12; (e and f) CXCR4. CXCR3 is expressed in the conjunctival stroma and perivascular endothelium (arrows). CXCL12 is positively expressed in both groups and is markedly shown in the basal epithelium-, endothelium- and conjunctiva-infiltrating leucocytes (arrows). Conjunctiva-infiltrating leucocytes also express CXCR4 (arrows).

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